it feels like decades since the first Stand auto for Science protests
ahead of this year’s protests tomorrow, I caught up with @cdelawalla.bsky.social to talk about what @standupforscience.bsky.social sees as its strategy as a fully formed organization
www.statnews.com/2026/03/06/s...
In just 3 days, the Take Back our Science Rally hits the streets in Washington DC and all across the country!
Join at local rally, or if nothing's nearby, start your own pop-up rally. Details at zurl.co/BlOzn
#science
#standupforscience
#rally
#March7
#FunScienceFact
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New Yorkers, let your state senator + legislator know you want to support science research at NYS-level to protect other New Yorkers, grow our economy, and create jobs. *Every call/email matters!* Follow @fundnyscience.bsky.social @nycures.bsky.social for how-to 🔬🥼💲
Notable talk from PDs across disciplines at MSSM, such as @alozano22.bsky.social who’s work in diet & liver cancer immunology heavily impacted by public-funding cuts, and how industry-driven funding has different priorities. Many of us feel it similarly @nychealthy.bsky.social @spocuaw.bsky.social
Powerful speech from @brownlab1.bsky.social on need for state-level funding of early research to keep smart folks in NYS and boost retention of startups/industry offshoots! Long term ($$$) stems from smart investment ($) @sinaiimmuno.bsky.social @drshrutinaik.bsky.social @miriammerad.bsky.social
Panel of scientists, state legislators, and UAW region 9A representatives in front of projector at Sinai Goldwurm auditorium.
Heartened to see complementary action @nycures.bsky.social @uawregion9a.bsky.social @spocuaw.bsky.social @rocsuaw.bsky.social driving “bolstering biotech initiative” in NYS for FY26. We need to fight together for rational sustainable research funding given threats/cuts. #science #BBI #NYS
The impact is already hitting science agencies hard. The NIH—the world's largest public biomedical research funder—has had to rely on leftover stopgap funds.
New grant awards have slowed to a trickle — exacerbating the effects of a record-long shutdown in October.
(h/t @jeremymberg.bsky.social)
Similarly, excited to see beautiful direct in vivo reprogramming updates from @cellreprolab.bsky.social Asgard Tx, esp their observation that DC-like reprogrammed tumorcells enhance functional TLS and license abscopal effect. Aligns well with our story coming out soon @miriammerad.bsky.social
Wrapping up #KSMyeloid26, enjoyed @tfabre.bsky.social
rigorous + rational approach to classifying and targeting myeloid cells in fibrotic diseases. Look forward eagerly to testing their M.A.C.S approach built on scLAVI @mmschaefer.bsky.social
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Thank you!
#standupforscience
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#March7
Enjoyed talk from @gaoteng.bsky.social @bloodgenes.bsky.social on mitoDrift, revised approach based on population genetics modeling to account for heteroplasmy drift. Strong vignettes showing their tracing aligns with LARRY groundtruth barcoding, validate reduced My/Ery clonality w/ age. AP-1 again!
Very cool work from AJ Daniels @signerlab.bsky.social who have developed a mouse model for enhanced translational fidelity (Rps23-K60R) that rejuvenates hematopoietic age. Protein synthesis stress decoupled from translational fidelity, such a crucial concept for HSC biology and fitness.
Notable talk from Arushana Maknojia @thekinglab.bsky.social who describes long-range comm between gut microbial metabolites and BM HSCs which activates endog-retroelements (ERE) to support hematopoeitic expansion. Matches what we are seeing in ageing. #sensing #immunology
Excellent short talks now #KSHemato26. First, Sara Tomei @shalinhnaik.bsky.social describing how HaemaTONIC-enabled marker discovery reveals CD200 as a distinguisher for erythroid-biased vs multipotent hu HSCs! V useful as folks design selection strategies clinically. @keystonesymposia.bsky.social
Now at #KSHemato26; Britta Will @einsteinmededu.bsky.social shows super-cool work highlighting the role of chaperone-mediated autophagy (CMA) in HSC function and leukemia resistance. Big role for proteostasis upon cysteine stress, which aligns so well with what I see in pathogenic myelopoiesis !
Final day of #KSMyeloid26 ! Really enjoyed @bainlab.bsky.social talk on RTM repopulation dynamics post-infection. Notable, their work underscores that monocyte replenishment of AM niche (clodr) is sufficient (not Ag from prior infection) for protection. "Monocyte legacy, not training !"
(JUMPING CONF #KSHemato26) Amazing talk from @juliabelk.bsky.social who is doing cutting-edge work to trace replacement of microglia in humans, using passenger mutation-assisted clonal tracing (PACT). More microglia are monocyte-derived than expected, our brains are not as protected after all !
Always a mind-blowing talk from @sancholab.bsky.social
who showed, alongside cool data on macs, that cIII inhibition in cDC1 has functional consequence on anti-tumor immunity > mitochondrial ETC disruption impact on histone demethylase and alter PU.1 pioneer activity. Everything linked !
Next, Isabelle Arnold (ETHZ) with a very intriguing talk on neonatal eosinophil biology, showing elegantly how important this population is to microbial homeostasis and immunity later in life. Alongside @arielmunitz.bsky.social , nice representation for these PHILs. #KSMyeloid26
Afternoon session full of great talk at #KSMyeloid26. First, Zimmerman lab (Oklahoma) walks us through the complex and surprisingly non-canonical behavior of renal macs, specifically how Trem2hi macs dictate PKD phenotypes. @keystonesymposia.bsky.social
Masterclass from Dan Puleston on metabolic control of aging ! @sinaiimmuno.bsky.social @miriammerad.bsky.social Fundamental shift in how we think of tissular aging– bioavailability of amino acids will dictate niche repopulation and mac fitness, in turn maintaining function. 🤯 #KSMyeloid26
Great to finally hear Lai Guan Ng in-person, such a clarifying talk on neutr heterogeneity (see www.cell.com/immunity/abs... and also showed cool data on their feature-proj based framework for classifying TANs. Hope I can someday convince him that BM changes impact TAN fate :D #KSMyeloid26
Day 2 at @KeystoneSymp kicked off by @charlottelscott.bsky.social on liver Mac biology in the context of MASLD and HCC progression. Excellent work showing how little we still understand about Kupffer cells, and how fibrosis is uncoupled from KC activation in the liver. #KSHemato26 #KSMyeloid26
Excellent talk from Jennifer Guerriero @dfcicancerbio.bsky.social
on their clinic-facing work showing importance of TREM2hi lipid-assoc LAMs in breast cancer, the role of these macs in driving PARPi resistance, and their approach to CAR-Macs to target TREM2 in TME and ablate LAMs. #KSMyeloid26
Following up is Stefani Spranger @mitkochinstitute.bsky.social
with a very exciting story on CD103+CD11b+ (dp) DCs playing an important role in CPAC-SIY model of high-grade ovarian cancer. Would be great to see how they localize for local restim (TLS or aggregates?). #KSMyeloid26
Great short talks followed by session on 'Myeloid cells in Tumors'. Started off by @arielmunitz.bsky.social
with very cool provocative data of STAT3 signaling driving tumor eosinophil-CD8 T cell interaction in lung mets. #KSMyeloid26
Standout ST from Silvia Pires from RandyLongman lab @weillcornell.bsky.social showing education of neutrophilic lineages in IBD by GM-CSF from TL1A-activated ILC3, driving pro-tumoral specification (+ link to arthritis via training). So cool to see the EM grammar holding true ! #KSMyeloid26
Super cool work from @shalinhnaik.bsky.social
on scaling up DC1 immunotherapy (modular differentiation using BATF3) as well as CAR-approach based activation in situ to avoid classical issues with DC manufacturing (GM-DCs and tolerogenic). Gargantuan effort at @petermaccc.bsky.social ! #KSMyeloid26
Great kick-off to the conference by @florentginhoux.bsky.social
covering diet-dependent regulation of resident tissue macs as well as developmental + functional heterogeneity of tumoral macs ! #KSHemato26 #KSMyeloid26
Now that data is out (which still doesn’t capture the whole picture), can you please stop telling ESI’s, etc. not to worry about grants because there haven’t really been any major changes? Please and thank you.
