DeshmukhLab

The NLRP1 #inflammasome is an essential and selective mediator of #axon pruning in #neurons.

-> www.embopress.org/doi/full/10....

The NLRP1 inflammasome is an essential and selective mediator of axon pruning in neurons | EMBO reports imageimageAxon pruning, the selective degeneration of axons, requires many apoptotic proteins, though it is distinct from apoptosis. This study identifies two inflammasome proteins, Caspase-1 and NLRP...

doi.org/10.1038/s443...

Our discovery that the inflammasome protein NLRP1 regulates axon pruning in neurons published @EMBOreports.org This was unexpected because inflammasome proteins are typically activated by immune cells in response to pathogen infection. Selena Romero uncovered a cool function of NLRP1 in neurons!

The unexpected role of a pathogen-sensing immune protein in the brain - Department of Cell Biology and Physiology Trimming neuronal axons involves a distinct pathway and a rare pathogen-sensing immune protein that could have implications for Alzheimer’s disease. Neurons have the remarkable ability to kill parts o...

CBP scientist Selena Romero just found an #immune protein involved in responding to viral infections has an unexpected role in the brain. "What the heck is it doing in #neurons in a nonpathogenic or diseased setting,” said @deshmukhlab.bsky.social Read more here: www.med.unc.edu/cellbiophysi...

Hello Bluesky world! Delighted to be here. No better way to start than to share with you an image of beautiful “Bluesky” neurons in microfluidic triple chambers (thanks to Selena Romero, Matt Geden in our lab).