Kurianlab

Regulatory paradigm of Dscam1 stochastic alternative splicing through conserved long-range RNA structures Abstract. Pancrustacean Dscam1 genes encode 2 000–120 000 distinct isoforms via mutually exclusive splicing; however, the underlying regulatory mechanisms

academic.oup.com/nar/article/...

Check this

🙂 #istandwithjesse

Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction Self-amplifying RNA (saRNA) enables sustained protein expression from a single administration. In this study, we developed an intramuscular saRNA-lipid nanoparticle (saNppa-LNP) therapy encoding natri...

www.science.org/doi/10.1126/...

This is clever, very clever

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev

I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳

Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/...

#TEsky #RNAsky #RNAbiology #immunity #NAR

@mads100tist.bsky.social

Good that Jesse found his better talent in science

Interested in G-quadruplex RNA structures, protein-RNA interactions, cooperativity, or splicing. Check out our latest study from our collaborative research center for polymer concepts.

@sfb1551.bsky.social @zarnack-group.bsky.social

Check this beauty

Congrats Filipe!

We are excited to share our new preprint: iCLIP3 — an improved protocol for transcriptome-wide mapping of protein–RNA interactions at single-nucleotide resolution.

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life Giant DNA viruses encode a cap-binding complex homologous to eIF4F, the defining translation-initiation complex of eukaryotes. The viral cap-binding complex is required for viral protein synthesis and...

www.cell.com/cell/fulltex...

www.biorxiv.org/content/10.6...

Engineering intrinsically disordered regions for guiding genome navigation Intrinsically disordered regions (IDRs) navigate transcription factors (TFs) to their binding sites in genomes, raising the question of how IDR sequen…

Beautiful and intriguing piece of work on the role of hydrophobic residues in IDRs in guiding TFs to their binding sites
www.sciencedirect.com/science/arti...

The US is dragging Europe back to the days of white supremacism. Our leaders are playing along | Shada Islam People like me were targets of the Islamophobia that gripped the west after the US-led ‘war on terror’. Now I fear a chilling sequel is on the way, says Shada Islam, a Brussels-based commentator on EU...

'Judging by the applause Rubio received in Munich, I fear that too many European leaders have already signalled their readiness to play along, either because they share Trump’s worldview or because it feels geopolitically expedient to do so.'
www.theguardian.com/commentisfre...

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

www.nature.com/articles/s41...

www.biorxiv.org/content/10.1...

Rapid directed evolution guided by protein language models and epistatic interactions Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...

www.science.org/doi/10.1126/...

what a beautiful paper from the Schuman lab

We recently updated our paper demonstrating evidence of off-target probe binding affecting the 10x Genomics Xenium spatial transcriptomics platform with key clarifications, new quantifications, and approaches for evaluating custom gene panels: biorxiv.org/content/10.1...

🧵👇1/n

Yoon Suk Yeol: South Korea’s ex-president jailed for life for masterminding an insurrection Yoon Suk Yeol was impeached and indicted for declaring martial law in 2024.

www.bbc.com/news/live/cq...

How accountability works in democracies where the rule of law is still valued

Bhattacharya is the science equivalent of 'the Mooch'. such a waste of oxygen....

We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

Screenshot of a CNN segment shared by Acyn. A split-screen shows commentator Lydia Moynihan on the left and Kevin O’Leary on the right during a heated exchange. The chyron reads, “Obama: Dems need to avoid scolding and ‘virtue-signaling.’” The post quotes O’Leary referencing China and concentration camps, and McGowan responding about West Virginia.

I spent my childhood inside of American concentration camps. I know one when I see one. And that is what ICE is building.

Advances in CLIP-derived methods have enabled high-resolution mapping of individual RNA binding protein-RNA interactions as well as RNA binding protein-associated RNA–RNA interactions #RNA #CLIP @evannostrandlab.bsky.social bit.ly/4bYjAsg

Ofelia Torres, teen who fought to have her father released from ICE custody, dies from rare cancer Ofelia Torres, 16, died on Friday from Stage 4 alveolar rhabdomyosarcoma, a rare and aggressive form of cancer, her father's lawyer confirmed.

A child dying of cancer spent her final days fighting to free her wrongfully detained father from ICE custody.
 
This comes just weeks after a mother from Maryland was denied the right to be at her son’s side as he died from cancer.
 
Not one dime for this cruelty.

www.cbsnews.com/amp/chicago/...

"You can just decide that you don’t know things, it turns out, even if you do know them. You can simply decide to forget progress. Disease is caused by miasma, insufficient beef tallow, corn syrup, the evil eye. You can simply decide to burn coal and witches and books again."

Daily mtDNA Research Briefing Header

Daily #mtDNA intel: • mtDNA inheritance enables lineage tracing 🧬 • LONP1 variants linked to diverse phenotypes • HSP90α/DRP1 axis triggers sepsis brain injury 🔬 #mitochondria

📄 Full Dossier | 🎙️ Podcast

Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...

7-Year-Old Migrant Girl Dies Of Dehydration And Shock In U.S. Border Patrol Custody The girl's death underscores the crisis precipitated by large groups of families seeking asylum where there are inadequate facilities to detain them.

CBP didn’t give her or anyone any water; she asked 3 times accg to other reports. CBP killed a 7yr old.

“8 hours after the girl & her father were taken into custody, she began having seizures & her body temperature was measured at 105.7 degrees by emergency medical technicians. shorturl.at/d2OTJ

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

www.nature.com/articles/s42...

A fantastic effort by first authors Huib Rabouw, @janinschoko.bsky.social, @michamuller.bsky.social with lots of help in image analysis by @baarsmatthijs.bsky.social and @jakobpueschel.bsky.social. Also a great collaboration with the groups of @hansclevers.bsky.social and Ron Fouchier!

The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 Weiss et al. structurally and functionally characterize the interplay between the human BAF chromatin remodeler and nucleosome-bound pioneer transcription factors, uncovering a highly dynamic remodeling process in which nucleosome-bound transcription factors bias the direction of BAF remodeling to regulate genome access.

Online Now: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 Online now: