Sarah Shammas

There are still spots left for dinner!

The @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for research accomplishments with disordered proteins. APPLY by sending your nomination packet to idpsubgroupbps@gmail.com by Dec 15th! Info at:

www.biophysics.org/awards-fundi...

One week left to apply!

Fantastic Alex!!! Congratulations. It's so well deserved. And what a beautiful tribute in your thread.

Please share with anyone you think may be interested

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!

Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!

biophysics
transcription
protein:DNA interactions

my.corehr.com/pls/uoxrecru...

In the spirit of scientific progress if you have any thoughts after reading our manuscript I am happy to hear from you. Please email me on sarah.shammas@bioch.ox.ac.uk.

All but one bZIP monomer, Jun, has significantly higher affinity for other monomers than its own DNA target, favouring the dimer pathway for target search at equilibrium.

Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA.

www.biorxiv.org/content/10.1...

I'm excited to be invited alongside the fabulous Sonia Longhi to present at IDPseminars this Thursday. I will talk about some of our work with disordered DNA binding domains.

Engineering a genomically recoded organism with one stop codon - Nature Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...

Just one stop. www.nature.com/articles/s41...

Information flyer for IDPSeminars/Biophysics week event - all details at https://idpseminars.com/

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...

PhD opportunities (yes, plural!)

We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.

- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚

Attn. Intrinsically Disordered Proteins Subgroup members:
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles

You can purchase a dinner ticket:
www.biophysics.org/store/produc...

Opportunity for postdocs in IDP related biophysics research! The deadline is coming up quite soon.

A paper to cite!

I've been waiting to see this come out. Congratulations! I look forward to sharing this paper with my undergraduates too :-)

Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers: Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH Professor Ylva Ivarsson, Uppsala University, Sweden Dr. Michael Wehr, Systasy Bioscience, Munich, Germany Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary Professor Kristian Strømgaard, HEALTH, UCPH Professor Stefano Gianni, Sprienza University of Rome, Italy Professor Per Jemth, Uppsala University, Sweden Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark Professor Benjamin Schuler, University of Zurich, Switzerland Professor Alfonse De Simone, University of Naples, Italy Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH

If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...

Improved protein binder design using ꞵ-pairing targeted RFdiffusion Despite recent advances in the computational design of protein binders, designing proteins that bind with high affinity to polar protein targets remains an outstanding problem. Here we show that RFdif...

www.biorxiv.org/content/10.1...

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EMBL Jobs We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.

My first post on Blue Sky - moving over !

For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...

New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...

BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L

Register for the upcoming JUST-B Seminar on Nov. 19th at 11am PST / 2pm EST to learn about the science of two amazing PhD students❗️❗️❗️

Register here: biophysics.org/store/products…

@blackinx.bsky.social

Download our database of 313 different postdoctoral fellowships.

For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).

Download our database here: research.jhu.edu/rdt/funding-...

Looking forward to reading this today