Mohanad Al-Obaidi

Omadacycline Monotherapy in Nontuberculous Mycobacterial Pulmonary Disease Caused by Mycobacterium abscessus: Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study In this randomized, controlled trial of patients with nontuberculous mycobacterial pulmonary disease caused by Mycobacterium abscessus, symptom and microbi

Phase 2 data on omadacycline use in treatment of pulmonary M abscessus
#IDSky

A whole fish sits next to salt and rice filled barrels, I think. It's got stylized kanji in vertical lines along the side. There are trays of cuts of fish, or vegetables next to the barrels.

I'm craving sushi: let's talk about who *invented it*.

Our story starts in the Mekong River valley: Laos, Cambodia, Thailand.

Locals realize they can preserve river fish in barrels with layers of salt & rice for YEARS, a precaution against drought, famine.

Immunomodulation in the Treatment of Disseminated Coccidioidomycosis Severe coccidioidomycosis carries high mortality despite antifungals. We treated 18 refractory cases with immune modulation, including augmentation of Type

academic.oup.com/cid/advance-...

#IDSky #MedMyco

Case of <em>Legionella pneumophila</em> Serogroup 1 Infection Linked to Water Flosser, France <em>L. pneumophila</em> Infection Linked to Water Flosser

A 🕵️ was in this case investigation:

While performing investigation of water system in pt w/ Legionella, infection control found an unregistered water flosser.

They ran sterile water through flosser and Legionella grew + matched infection strain

wwwnc.cdc.gov/eid/article/...

#IDSky

Development Framework of Desirability of Outcome Ranking Endpoints for Use in Clinical Trials of Invasive Fungal Diseases Utilizing a modified Delphi process, 53 fungal experts from 16 countries developed consensus endpoints for clinical trials targeting invasive candidiasis,

Framework for pivoting to #DOOR in #mycology! Very excited about this publication from @msgerc.bsky.social #IDSky #MedSky academic.oup.com/ofid/article...

Diagnostic Yield of Repeat Blood Cultures and Risk Factors for Bloodstream Infection in Persistent Febrile Neutropenia New bloodstream infections after day 3 of febrile neutropenia (FN) were uncommon in patients with cancer and hematopoietic cell transplant (HCT) recipients

New @cidjournal.bsky.social article on febrile neutropenia from @uwidfellowship.bsky.social:

“Of 503 patients with ≥1 blood culture collected after FN day 3, 19 (4%) had a new BSI after FN day 3”

Authors suggest low utility of repeat BCx after day 3

#IDSky

academic.oup.com/cid/advance-...

Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance | Antimicrobial Agents and Chemotherapy Aspergillus species are a major cause of fungal-related morbidity and mortality worldwide, particularly among individuals with chronic obstructive pulmonary disease (1), patients in intensive care uni...

Beyond Fumigatus: a molecular portrait of clinical Aspergillus diversity, pathogenicity, and antifungal resistance. #MedMyc #infectiousdisease #IDSky

Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France This first report of olorofim use in real-world clinical practice highlights the promising efficacy and good tolerability of olorofim in patients with inva

academic.oup.com/ofid/advance...

Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors.

Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis

#IDSky

#idboardreview 60 M idiopathic pulmonary fibrosis s/p lung transplant 2wks ago( on antithymocyte globulin, tacro, azathioprine, pred) now w/ pleuritic chest pain, dyspnea. +emypema s/p drainage: pinpoint colonies. diagnosis? #medEd #idmedEd #idsky

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.

If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

"Cocoa farmer David Kebu Jnr holding fermenting cocoa beans." "Photo taken by Irene Scott for AusAID. (13/2529)"

There are two fungi naturally found on seed pods:
1. Picha kudriavzevii (a unicellular yeast)
2. Geotrichum candidum (multicellular fungus)

Also present are lactic acid & acetic acid bacteria. Between them all they acidify & break down as much as 90% of the bitter polyphenols.

#Medsky🧪 #IDsky #Episky #neurosky #immunosky #publichealth @bmj.com Studies have shown that inflammatory alterations in the 🧠 caused by ( #Herpessimplexvirus 1 ) HSV infection are pivotal in #Alzheimersdisease development.

bmjopen.bmj.com/content/15/5...

journals.sagepub.com/doi/pdf/10.1...

Congratulations!

Figure. Hospital-Level Correlations Between Mortality Outcomes Among Patients With Sepsis

In this all-payer, multihospital cohort of patients with community-onset sepsis, the proportion of hospitalizations ending in death or hospice discharge was similar to 30-day mortality and substantially higher than in-hospital mortality alone. https://ja.ma/4kEpu2R

Candida vulturna, the Next Fungal Menace? A Narrative Review Introduction The yeast Candida vulturna is a member of the Candida haemulonii species complex, like its close relative Candida auris. Members of this species complex, including C. vulturna, often di...

Candida vulturna (member of Candida haemulonii species complex)can be misidentified with reduced azole and ampho susceptibilities. #MedMyco #IDSky

This ancient pathogen became deadlier when humans started wearing wool Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

I never thought about wool as a possible route of infection.

www.nature.com/articles/d41...

#IDSky #MedSky

MSGERC is seeking fungal infection cases (common or unusual) for Case of the Month.

Do you have a case? Submit it to be featured on DrFungus.org!

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People
#IDSky #MedMyco #histoplasma

New! #Candidaauris meeting in Miami… join us #IDSky med.miami.edu/departments/...

#MedSky #IDSky #MedMyco

The Fourth International Consensus Guidelines on the... : Transplantation An abstract is unavailable.

Excited to share the fourth version of the international consensus guidelines on CMV management after a solid organ transplant, on behalf of all 50 contributors and @ttsorg.bsky.social journals.lww.com/transplantjo...

Longitudinal Assessment of the Effect of Invasive Fungal Infections on Transplant Success in Kidney Transplant Recipients Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTR), but their effect on allograft fu…

www.sciencedirect.com/science/arti...

#IDSKy #MedMyco #TxID

New post on gepotidacin (pronounced "JEP-oh-TIE-dah-SIN"), a new antibiotic for uncomplicated UTIs with a brand name that sounds like it should be nesting in the Costa Rican rainforest.
(I kind of went off the rails on this one.) #IDSky blogs.jwatch.org/hiv-id-obser...

Deadly fungi are becoming drug-resistant. A new compound could beat them A drug candidate with a new mechanism of action shows promise against several drug-resistant infections in mice

Another bit of hopeful news, from @kakape.bsky.social: www.science.org/content/arti...

Purified T cell transplant lowers risk of immune reaction for blood cancer patients, study shows A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune reaction in patients with several types of blood cancer.

#TxID #MedSky
“In the study, which enrolled 187 patients with four different types of leukemia, the T cell therapy called Orca-T reduced the risk of chronic graft versus host disease (GVHD) by 74% compared to a conventional matched-donor, or allogeneic, stem-cell”
www.statnews.com/2025/03/17/o...

🔍 108 Coccidioides peptides identified for VF diagnosis. They re-activated CD4+ T-cells in infected individuals vs. controls, aiding in diagnostic assay development. 🦠💉

#idsky

Effects of cancer therapy on AMR

Cisplatin➡️cross-resistance to FQ (target bacterial DNA)

Methotrexate➡️dihydrofolate reductase mutations➡️co-select for β-lactams/AG/fosfo resistance

Anthracyclines➡️efflux pump expression

Etoposide➡️oxidative stress➡️gyrA mutations

doi.org/10.1016/j.la...

#IDSky

The 2024-2025 COVID-19 Vaccine Show Limited Efficacy in Adults The interim results demonstrated a slightly better vaccine effectiveness in individuals who are immunocompetent vs immunocompromised individuals.

The interim results demonstrated a slightly better vaccine effectiveness in individuals who are immunocompetent vs immunocompromised individuals. #IDsky #Medsky