Mark McCarthy

Spending tonight with everyone’s favorite Glaswegians, Mogwai

Mogwai performing at the Regency Ballroom, San Francisco, 4/28/25

MOGWAI - San Francisco, April 28, 2025

Because sometimes you just want to atomize yourself in a wave of guitar feedback

It’s never a bad day when Mogwai shows up in town. First saw them in 1999. Love them more than ever…..

Exactly! Continues to amaze/frustrate me to find so many still place confidence in the value of differential expression/proteomics/methylation analyses of case control samples as a basis for causal inference.

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce".

Prepare to get cheesy, I'm glad to share the Cacio e paper preprint:

arxiv.org/abs/2501.00536

Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks - Nature Communications Identifying individuals at high risk for chronic diseases can improve prevention. Here, the authors show that blood metabolomics scores effectively stratify disease risk and compare favorably to genet...

Long awaited peer review finally completed!! Our paper comparing quantitative metabolomics disease risk prediction with PGS is accepted in Nature Comms!! 🥳🥳
@nightingalehealth.com #riskprediction #metabolomics #nmr #genomics #polygenicscore

www.nature.com/articles/s41...

Encoding innate ability through a genomic bottleneck | PNAS Animals are born with extensive innate behavioral capabilities, which arise from neural circuits encoded in the genome. However, the information ca...

A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...

Inspiring talk by @christian_happi from @acegid on scaling up genomics infrastructure on the African continent for combatting infectious diseases, from malaria to COVID @QMULBartsTheLon #WHD21

Love this

Sparse matrix factorization of GWAS summary statistics robust to sample sharing improves detection and interpretation of factors with diverse genetic architectures Complex trait-associated genetic variation is highly pleiotropic. This extensive pleiotropy implies that multi-phenotype analyses are informative for characterizing genetic variation, as they facilita...

Check out our new work led by @ashton_omdahl discussing matrix factorization across GWAS, accounting for sample overlap. Factors with varying polygenicity, enrichment for cell type / developmental stage... Ashton is speaking at #biodata24 today! www.biorxiv.org/content/10.1...

Twitter’s heir apparent isn’t X or Threads — it’s Bluesky The blue bird is dead. Long live the blue sky.

Others have noted it but I will too: The big reason Bluesky is so hot right now is that the people who add value to social media - the frequent posters in specific fields - are here now, talking to each other and creating the "spectator value" that draws users and attention.

It’s fantastic to find so many friends already here. As others have noted, this feels like the early days of science twitter (RIP).