Our new preprint is out!
A state-dependent neural circuit resolves approachβavoidance conflicts
www.biorxiv.org/content/10.6...
Fantastic work led by Devika Bodas, with key contributions from Marine Balcou, and a great collaboration with Lisa Scheunemann Lab, fearuting Εevval Demirci.
Wonderful paper nicely showing mitochondria as a memory booster, a must read!
Congrats @jdejuan-sanz.bsky.social and team :)
Happy to share our conceptual review π where we propose the gut not as a βsecond brainβ, but as a foundational, ancient visceral brain.
We propose that decentralising the brain starts with the gut.
Time to enter the Enterarchon π€―
CytoTape in a neuron
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
I am excited to share our review that was published in Molecular Oncology @moloncology.bsky.social entitled "Tumourβhost interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment"
febs.onlinelibrary.wiley.com/doi/10.1002/...
Delighted to have been part of this amazing team! β¨
Your gut has a sex, and it matters! π₯
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint π₯³
www.biorxiv.org/content/10.6...
Three layers of sexual dimorphism within the same neurons... three steps to reproduce. Congrats @neurogut.bsky.social @drosostalis.bsky.social and team!
thank you jose, we are indeed excited about this and as Dafni said will be happy to hear your thoughts! :)
Your gut has a sex, and it matters! π₯
In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating.
So excited my postdoc work is finally out as a preprint π₯³
www.biorxiv.org/content/10.6...
π£First preprint of the labπ£ Did that really happen?π
Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
Woohooooo, congraaats Nikos!! π. I will read it as soon as I get the time (I may poke @drosostalis.bsky.social for visual system guidance π)
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
Textbooks said neurons donβt burn fatty acids for energyπ€. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD π₯³, out today in Nature Metabolismπ₯ @natmetabolism.nature.com
many thanks, great that you like it :)
Congrats Jaime :) (totalmente merecido!)
meaning, neuromodulators and glia put whole compartments into a high energy learning state, but only the activated KC synapses in that compartment undergo lasting plasticity
very honestly, I donβt think we know yet how tight the spatial match is between this energetic state and the actual memory trace. I think learning in the MB is globally/metabolically enabled but locally written
thanks a lot, Cahir, really nice question and something Iβve been thinking about too. I think the metabolic pathways we monitor here are not confined to the tiny subset of odor activated KC/MBON synapses that are actually modified, but reflect a broader βMB in learning modeβ state
Thank you :), if only it worked like that π
would be amazing!
I think the fat these memory neurons burn is tiny compared with whole body metabolism so I would say no weight loss hack yet, just a cool brain energy trick for now ;)
thank you :)
Ten years in the making. For the full story behind the data, read the "Behind the Paper" piece π
Textbooks said neurons donβt burn fatty acids for energyπ€. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD π₯³, out today in Nature Metabolismπ₯ @natmetabolism.nature.com
Iβm thrilled to share my postdoc work and the first paper from the McKinley Lab! π
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. π§ͺ
www.biorxiv.org/content/10.1...
π§΅
under construction... πΆβπ«οΈ
oh thank you! :)
This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field πͺ
A restricted subset of gut-innervating neurons that express the neuropeptide myosuppressin (Ms) innervate the crop, a stomach-like structure of the fly intestine. This figure shows co-expression between the Ms protein reporter (green) and Ms peptide (red) in the nervous system, and in neuronal projections towards the gut (blue).
If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025
