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Dan Kaplan

@danhkaplan

Immunologist and Dermatologist at the University of Pittsburgh. The lab is interested in the interactions between immune and non-immune cells, especially sensory neurons.

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19.11.2024
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Latest posts by Dan Kaplan @danhkaplan

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To Scratch or Not to Scratch, That Is the Question Podcast Episode · Derms on Drugs · 03/14/2025 · 36m

Derm on Drugs is a podcast where some current and former U of Pitt faculty talk about dermatology. Here is an episode where I joined to talk about itch and scratching. It was a really fun time and they did a great job. #dermatology #immunology #eczema podcasts.apple.com/us/podcast/d...

19.03.2025 12:51 👍 4 🔁 0 💬 1 📌 0

I was scheduled for study section starting tomorrow. Everything's all done and ready to go. Just heard it's being "rescheduled." No reason given.

26.02.2025 17:27 👍 3 🔁 1 💬 1 📌 0

But winter itch is all about dryness. Moisturize!!!

31.01.2025 19:00 👍 1 🔁 0 💬 0 📌 0

It does suggest that targeting mast cells is something to focus on.

31.01.2025 19:00 👍 0 🔁 0 💬 0 📌 0

My PO says ours at end of Feb is still on. But who knows.

30.01.2025 22:38 👍 1 🔁 0 💬 0 📌 0

Also big thanks to the labs of Marlies Meisel and Tina Sumpter here at Pitt and all co-authors.

30.01.2025 20:35 👍 4 🔁 0 💬 1 📌 0
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Scratching more than an itch Enhanced antibacterial skin inflammation is an adaptation of the itch-scratch cycle

Also Aaron Ver Heul at Wash U wrote a lovely persepctive. www.science.org/doi/10.1126/...

30.01.2025 20:33 👍 11 🔁 2 💬 0 📌 0
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Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

30.01.2025 20:31 👍 191 🔁 57 💬 7 📌 8
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Feeling Itchy? Study Suggests Novel Way to Treat Inflammatory Skin Conditions - UPMC & Pitt Health Sciences News Blog A new approach to treat rosacea and other inflammatory skin… Read more

Also a summary of the work here #neuroimmunology

11.12.2024 21:55 👍 13 🔁 3 💬 0 📌 0

And I found some choice photographs to show for the introduction!!!

11.12.2024 19:11 👍 1 🔁 0 💬 0 📌 0
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Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.

New paper from Kaplan Lab. Agonizing a specific glutamate receptor on mast cells in the skin renders them less function and can suppress several models of skin inflammation. Congrats to Youran Zhang and all co-authors. #skinimmunology #immunology #mastcells www.science.org/doi/10.1126/...

11.12.2024 19:06 👍 28 🔁 2 💬 2 📌 2

Yes pls

23.11.2024 14:58 👍 1 🔁 0 💬 1 📌 0