Pawel Grzechnik

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

Thanks, Kinga!

Interested in antisense oligonucleotides?
Check our story about downstream-of-gene ASOs (DG-ASOs)!
Together with the Roche Innovation Center we
identified transcription termination windows of protein-coding genes as ASO target regions.

link to BioRxiv:
www.biorxiv.org/content/10.6...

RNA in physiology and disease | Genetics Society Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...

Have a look at this fantastic meeting and save the date!

The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.

genetics.org.uk/events/rna-i...

Two positions (research assistant and PhD student), great science and the cake!
Check @buckleylab.bsky.social thread for more info:
👇

Structural biologists!
Our division has an opening for a Lecturer/Senior Lecturer—apply now!

www.jobs.manchester.ac.uk/Job/JobDetai...

The University of Manchester, Division of Molecular and Cellular Function PhD Projects, Programmes & Scholarships - 21 PhDs Listed FindAPhD. Search Funded PhD Projects, Programmes & Scholarships at The University of Manchester, Division of Molecular and Cellular Function.

21 fully funded PhD projects are available in our division!

www.findaphd.com/phds/divisio...

Graham Pavitt

We are excited to announce that Professor Graham Pavitt, Chair in Molecular Biology, has been appointed as our new Head of Division!
Join us in welcoming Graham to his new role—we look forward to the exciting times ahead!

research.manchester.ac.uk/en/persons/g...

Early-career fellowships at the University of Manchester!

To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers:

www.bmh.manchester.ac.uk/research/sup...

Research Opportunities - Cancer Research UK Manchester Centre Explore the range of postgraduate cancer research opportunities available in Manchester.

Exciting PhD opportunity available in my lab for the students from Black heritage background. Apply soon. 🤞🤞🤞
@mcr-breastcentre.bsky.social @mcf-uom.bsky.social

CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity

📅 Deadline: 4 April

🔗 crukcentre.manchester.ac.uk/study/resear...

Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers Gene expression is tightly controlled by DNA elements called enhancers by associating with lineage-specific transcription factors. These enhancers transcribe non-coding RNAs (called enhancer RNAs or e...

Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for breast cancer scientists: www.biorxiv.org/content/10.1... @mcf-uom.bsky.social @mcr-breastcentre.bsky.social @mcrcnews.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project.
jobs.manchester.ac.uk/internal/Job...
@mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

Which side are you on?

UNITED24 - The initiative of the President of Ukraine UNITED24 was launched by the President of Ukraine Volodymyr Zelenskyy as the main venue for collecting charitable donations in support of Ukraine. Funds will be transferred to the official accounts of...

You can donate to support Ukraine's defence, humanitarian demining, medical aid, the rebuilding of Ukraine or education & science here: u24.gov.ua

I just donated. Slava Ukraini!

🇺🇦

Gegersen Lab The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells

Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...

a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them . ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .

We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social
DM me for inquiries
pl apply/share tinyurl.com/m6jnksk5

We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...

Pls. share: We're putting together a series on inequalities associated with academic mobility.

If you're a microbiologist and would like to share your experiences with visa difficulties, travel-related funding, mandated academic mobility requirements, etc, please write at tim@cell.com.

#MicroSky

Ever wondered how Pol II speed is controlled during productive elongation?
Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription

www.biorxiv.org/content/10.1...

The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1 Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...

📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis
www.biorxiv.org/content/10.1...

We joined the Laboratory Efficiency Assessment Framework (LEAF), reduced laboratory waste and energy usage, and made the lab more sustainable overall.
And so we got the LEAF GOLD award!

Controlling Transcription Elongation and Termination: More Than a Means to An End

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination Aberrant gene expression lies at the heart of many pathologies. This review will point out how 3′ end processing, the final mRNA-maturation step in th…

Pawel Grzechnik and Hannah Mischo discuss polyadenylation site recognition and what happens afterwards and how it can go wrong: Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination 14/ www.sciencedirect.com/science/arti...

some good reviews there!

Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️

Diagram showing archaeal cells containing two chromosomes bound by proteins prior to cell division.

📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea.

Supervised by me, @Steve Quinn & @georgerheath.bsky.social

www.findaphd.com/phds/project...
Open to Applicants Worldwide!

📅 January 6, 2025

#microsky #archaeasky

done!

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done!