Tal Nuriel, PhD

Meet three scientists who said no to Epstein The warning signs included a web search, a mother’s doubts, and inklings of a “sexist attitude”

Gotta love a story about a nice Jewish boy listening to the advice of his mother. www.science.org/content/arti...

This is a very carefully worded way of saying that all funding decisions are coming from top from here on out. Also, no more paylines. grants.nih.gov/news-events/...

I sure would like to have time to focus on completing and writing up the actual science. What a silly system we’ve got.

Why on earth would zoom’s default setting be to allow meeting attendees to annotate your shared screen? I gave a public seminar yesterday, and one of the attendees started drawing red lines on the presentation slides 🤦🏻‍♂️. I didn’t even know that was possible.

People who survive cancers are less likely to develop Alzheimer’s – this might be why A new mouse study suggests some cancers release signals that help the brain clear Alzheimer’s-linked proteins, offering clues to a long-standing medical mystery.

Bravo. This MIGHT be why. I wish every science joirnalism article framed it this way. theconversation.com/people-who-s...

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking
www.science.org/content/arti...

It looks like another government shutdown might be incoming. Which means more study section and council delays, and more scientists holding on by an ever thinning string. But you won’t see many scientists complaining, because I assume most of us agree that Congress needs to try and restrain ICE.

PhD: Genome Data Science - DEMENTIA RESEARCHER Kings College London offers fully funded PhDs using genome data science and AI to discover therapeutic targets for disease.

Fully funded PhD programme at Kings College London training researchers to use human genetics AI and multi omics for therapeutic target discovery. Closing date: 28th February

www.dementiaresearcher.nihr.ac.uk/job/phd-geno...

Well done!

Yes, I think that’s right.

I suspect that it is. I’m just having trouble with the framing of APOE3 as an Alzheimer’s variant. Is APOE3 “causing” Alzheimer’s, or does APOE2 just protect us from a process that happens in all of our brains as we get older?

Most Alzheimer’s cases linked to variants in a single gene Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

This study makes my head hurt. Can a gene variant that’s present in 95% of human beings (APOE3) be considered a risk allele? www.ucl.ac.uk/news/2026/ja...

Well, they were certainly clearer than they are now. I guess we’ll all find out together 😩

Yeah, that’s true. I guess I haven’t really contemplated what it would happens next. Is this the first funding round where the new rules apply?

I had an R21 reviewed this week, but no score yet. It does seem like forever since grants were last reviewed.

I have to amend this post for accuracy. It looks like about 375 of these "publications" are actually poster/presentation abstracts from AAIC. So not as huge of a year to year jump in APOE4 publications as it seems from the image.

Apparently 2025 was a big year for APOE4 publications

In maiden Senate speech, Andy Kim promises to care for his father and for America - New Jersey Globe Exactly one year after he was first sworn in as a U.S. Senator, Andy Kim gave his maiden speech on the Senate floor today. The speech, technically Kim’s

A powerful maiden speech by my senator, whose dad was recently diagnosed with Alzheimer’s disease. newjerseyglobe.com/congress/in-...

My lab member @arainhirra.bsky.social was saying that she thinks journals should pay scientists to publish their research. I hadn’t really thought about it, but now that I do…why haven’t there been smaller journals that have tried to leapfrog the larger journals by offering to buy high impact work?

ApoE directed Therapeutics in Alzheimer's disease, SFN 2025 Alzheimer’s disease has historically been viewed through the lens of amyloid plaques and tau tangles, but accumulating evidence shows that these features alone cannot fully explain why some individual...

APOE-directed therapeutics in AD: My first substack post: open.substack.com/pub/hyassine...

Currently watching Pluribus, and they’ve got their rats in mouse cages. Someone call IACUC.

Three rising stars in ageing research From Alzheimer’s to obesity, these researchers are tackling the most common age-related conditions.

www.nature.com/articles/d41...

That’s true. Although I do like FDG-PET. Would be great if we could make that more sensitive…but I don’t know enough about PET to understand the limitations on that. To me, the big problem is that fMRI techniques mostly rely on blood flow, but the vasculature itself becomes damaged.

Very cool! Will give it a closer read when I have time. I'm endlessly fascinated by the metabolic and activity changes that occur. Very hard to pin down the timing, especially since, as your graph shows, the activity/metabolism changes go up and then down. Definitely an important area of study!

6-year-old girl comes to the rescue of Harvard researchers studying the axolotl — CBS News Earlier this year, a Harvard research team studying the axolotl, a salamander with the superpower to regrow body parts, lost almost all its government funding.

Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...

I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.

Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.

Episode 23- Jenny Lange on the gothic history of neuroscience, a Halloween special

In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟‍♂️

spotify.link/2lHT9pLQRXb

Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.