Apply here:
www.researchhub.com/grant/5580/r...
Eligibility:
Open to PhD students, postdoctoral fellows, independent researchers, and early stage faculty worldwide. The funding may be used to support new or ongoing projects.
Link to application and more info below!
Please share among your network if you can!
(1) How large can we grow viable human brain organoids with improved vascularization, perfusion, and metabolic support?
(2) The Organoid Network: Can we dissect or engineer communication between organoids.
(3) What network level or cognitive like signals emerge?
Therefore, together with ResearchHub we are offering $25,000 in seed funding to support bold, high risk ideas in brain organoid research, including but not limited to the following areas.
I am super excited about this one. Over the past years it has become clear that brain organoid research is no longer only about disease modeling. The field is growing fast. We can now start asking more fundamental questions about biological complexity, scaling, network formation, and cognition.
π§ New funding opportunity for all scientists working on brain organoids π§
Neutrophil-neuronal crosstalk drives arthritis-induced pain www.researchhub.com/paper/106078...
New study shows that TGFΞ² signaling is crucial for maintaining microglial resilience to myelin degeneration during aging.
This highlights a previously unresolved checkpoint of TGFΞ² signaling with regional specificity and spatially restricted microgliaβoligodendrocyte interactions.
Check out the news article about our recent work on cell therapies for stroke by Drug Target Review:
www.drugtargetreview.com/news/187869/...
More info about the original study can be found here:
www.nature.com/articles/s41...
Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis
Eleven clinical trials that will shape medicine in 2026
Happy to see a lot of cell-based therapies!
hiPSC-derived Neural Progenitor Cells support long-term (43 dpi) graft neuronal integration & functional recovery after photothrombotic Strokeπ
π57% neurites extend along cc into contralateral hemisphere
GraftsβΆοΈ44% GABAergic Neurons
@rrust.bsky.social #NatComm 2025
www.nature.com/articles/s41...
CleLight: A scalable 3D histology pipeline for mappingneurodegenerative and psychiatric pathology in archivalhuman brains www.researchhub.com/paper/105900...
βTime is brainβ for cell therapies?π§
Our #AdvSci perspectiveπ
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social
#StemCellTherapy for #Stroke should be timed to a biomarker-defined βwindow of receptivityβ, not just the thrombolysis clock
advanced.onlinelibrary.wiley.com/doi/10.1002/...
New in @natureportfolio.nature.com on microglial regulation in Alzheimerβs disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!
Great work π mapping how brain endothelial cells communicate with astrocyte endfeet at the bloodβbrain barrier in @natureportfolio.nature.com
The study identifies ligandβreceptor pairs conserved in humans and altered in MS and Alzheimerβs.
Makes me also wonder how many could be druggable targets.
Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.
Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbMβcortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social
The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social
Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes.
These findings link vascular risk and Alzheimerβs mechanisms.
Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-ΞΊB Response
www.mdpi.com/1422-0067/26...
Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinsonβs disease treatment!
cell.com/cell-stem-ce...
Great study dissecting molecular hallmarks of neuronal resilience in Alzheimerβs disease highlighting natural protective mechanisms that could help preserve cognition.
x.com/rust_ruslan/...