Ruslan Rust's Avatar

Ruslan Rust

@rrust

Asst Prof at @keckmedicineusc.bsky.social with interest in the #brain, #BBB, #stemcells and what can go wrong following #stroke & #AD. 🧠 πŸ”¬ Alumni of @ethzurich.bsky.social

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22.11.2024
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Latest posts by Ruslan Rust @rrust

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Request for Proposals - Project Gigabrain (Brain Organoids) Request for Proposals - Project Gigabrain (Brain Organoids) Ob...

Apply here:
www.researchhub.com/grant/5580/r...

14.02.2026 18:33 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Eligibility:
Open to PhD students, postdoctoral fellows, independent researchers, and early stage faculty worldwide. The funding may be used to support new or ongoing projects.

Link to application and more info below!

Please share among your network if you can!

14.02.2026 18:33 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

(1) How large can we grow viable human brain organoids with improved vascularization, perfusion, and metabolic support?

(2) The Organoid Network: Can we dissect or engineer communication between organoids.

(3) What network level or cognitive like signals emerge?

14.02.2026 18:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Therefore, together with ResearchHub we are offering $25,000 in seed funding to support bold, high risk ideas in brain organoid research, including but not limited to the following areas.

14.02.2026 18:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

I am super excited about this one. Over the past years it has become clear that brain organoid research is no longer only about disease modeling. The field is growing fast. We can now start asking more fundamental questions about biological complexity, scaling, network formation, and cognition.

14.02.2026 18:33 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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🧠 New funding opportunity for all scientists working on brain organoids 🧠

14.02.2026 18:33 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Neutrophil-neuronal crosstalk drives arthritis-induced pain Pain in rheumatoid arthritis (RA) often persists despite effec...

Neutrophil-neuronal crosstalk drives arthritis-induced pain www.researchhub.com/paper/106078...

17.01.2026 02:09 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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TGFΞ² signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFΞ² signaling in microglia, revealing a protective mechanism for healthy aging.

www.nature.com/articles/s41...

05.01.2026 20:40 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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New study shows that TGFΞ² signaling is crucial for maintaining microglial resilience to myelin degeneration during aging.

This highlights a previously unresolved checkpoint of TGFΞ² signaling with regional specificity and spatially restricted microglia–oligodendrocyte interactions.

05.01.2026 20:40 πŸ‘ 9 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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New stem cell approach could repair stroke-damaged brains Explore the impact of stroke and the latest research on stem cell therapy aimed at improving recovery from ischemic strokes.

Check out the news article about our recent work on cell therapies for stroke by Drug Target Review:
www.drugtargetreview.com/news/187869/...

More info about the original study can be found here:
www.nature.com/articles/s41...

05.01.2026 00:57 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis - Journal of Neuroinflammation Astrocytes are key regulators of neuroinflammation in multiple sclerosis (MS). Electroacupuncture (EA), a safe and cost-effective adjuvant therapy, has shown benefits in neurodegenerative diseases, bu...

link.springer.com/article/10.1...

04.01.2026 16:16 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis

04.01.2026 16:16 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Eleven clinical trials that will shape medicine in 2026 - Nature Medicine Nature Medicine asks leading researchers to name their top clinical trial for 2026, from long-awaited vaccines for infectious diseases to new treatments for advanced cancers and long COVID.

www.nature.com/articles/s41...

04.01.2026 16:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Eleven clinical trials that will shape medicine in 2026

Happy to see a lot of cell-based therapies!

04.01.2026 16:14 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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hiPSC-derived Neural Progenitor Cells support long-term (43 dpi) graft neuronal integration & functional recovery after photothrombotic Stroke🐭

πŸ‘‰57% neurites extend along cc into contralateral hemisphere

Grafts▢️44% GABAergic Neurons

@rrust.bsky.social #NatComm 2025
www.nature.com/articles/s41...

01.01.2026 14:20 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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CleLight: A scalable 3D histology pipeline for mappingneu... Mesoscopic brain imaging, enabled by advances in tissue cleari...

CleLight: A scalable 3D histology pipeline for mappingneurodegenerative and psychiatric pathology in archivalhuman brains www.researchhub.com/paper/105900...

21.12.2025 03:18 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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β€œTime is brain” for cell therapies?🧠

Our #AdvSci perspectiveπŸ˜†
@rrust.bsky.social
@dominikusbrian.com
@lydenlab.bsky.social

#StemCellTherapy for #Stroke should be timed to a biomarker-defined β€œwindow of receptivity”, not just the thrombolysis clock

advanced.onlinelibrary.wiley.com/doi/10.1002/...

18.11.2025 20:06 πŸ‘ 28 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1
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Lymphoid gene expression supports neuroprotective microglia function - Nature PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...

www.nature.com/articles/s41...

07.11.2025 22:13 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!

07.11.2025 22:13 πŸ‘ 11 πŸ” 3 πŸ’¬ 2 πŸ“Œ 1
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Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human - Nature Communications Deciphering body-brain communication pathways is key to a deeper understanding of brain physiology and pathology. Here, the authors define the astrocyte endfoot proteome and show dynamic vascular-to-a...

www.nature.com/articles/s41...

06.11.2025 18:50 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Great work πŸ‘ mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com

The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s.

Makes me also wonder how many could be druggable targets.

06.11.2025 18:50 πŸ‘ 13 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
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Thiorphan reprograms neurons to promote functional recovery after spinal cord injury - Nature Thiorphan is identified as a new and effective drug treatment for spinal cord injury that can be adopted across nervous system disease states in the development of new therapies for human neurological...

Link: www.nature.com/articles/s41...

04.11.2025 19:45 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.

04.11.2025 19:44 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids The nucleus basalis of Meynert (nbM) regulates cortical function and cognition. Liu and colleagues report a method for creating human nbM organoids (hnbMOs) containing cholinergic projection neurons t...

Link: www.cell.com/cell-stem-ce...

04.11.2025 17:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbM–cortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social

04.11.2025 17:14 πŸ‘ 2 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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The brain neurovascular epigenome and its association with dementia Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s disease and cerebral small vessel disease within neurovascular cells, identifying immune-related AD risk and bro...

www.cell.com/neuron/fullt...

04.11.2025 05:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social

Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes.

These findings link vascular risk and Alzheimer’s mechanisms.

04.11.2025 05:32 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-ΞΊB Response

www.mdpi.com/1422-0067/26...

30.10.2025 19:35 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinson’s disease treatment!
cell.com/cell-stem-ce...

30.10.2025 15:48 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1
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Great study dissecting molecular hallmarks of neuronal resilience in Alzheimer’s disease highlighting natural protective mechanisms that could help preserve cognition.

x.com/rust_ruslan/...

30.10.2025 14:24 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0