Melissa Bollmeyer

Thanks!

Insights into the initial steps of the thiamin pyrimidine synthase (ThiC)-catalyzed reaction through EPR spectroscopic characterization of radical intermediates Thiamin pyrimidine synthase (ThiC) is a noncanonical radical SAM enzyme that catalyzes the complex radical rearrangement of aminoimidazole ribonucleotide (AIR) to hydroxymethylpyrimidine phosphate (HM...

I’m excited to share my postdoctoral work on the mechanism of ThiC! In this collaborative effort, we combined advanced EPR with organic synthesis and DFT to characterize three intermediates of the complex 20-step radical cascade.

doi.org/10.1039/D5SC...