Craig A. Goodman

Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3 and MKK6 and the muscle recovers The MAPK p38α is associated with skeletal muscle’s development, differentiation and functionality. But, as it is overactive in muscle diseases and aging, it was proposed to be a pivotal promoter of th...

Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3 and MKK6 and the muscle recovers
www.jbc.org/article/S002...

Human plasma extracellular vesicles as an exercise mimetic to preserve skeletal muscle plasticity during disuse
www.nature.com/articles/s41...

Independent effects of whey protein and alkali supplementation on muscle health in healthy older adults: factorial randomized controlled trial Aging is accompanied by reduced muscle protein synthesis and increased circulating acid, both of which contribute to declines in muscle health.To dete…

Independent effects of whey protein and alkali supplementation on muscle health in healthy older adults: factorial randomized controlled trial
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The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice Cancer cachexia is a wasting syndrome characterized by reduced food intake and lean and fat tissue loss. In mice, cancer cachexia involved marked redu…

The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
www.sciencedirect.com/science/arti...

Plasticity in the structure and assembly of proteasomes Proteasomes are large multisubunit protease complexes found in all domains of life, where they execute regulatory and quality control degradation critical for organismal health. The canonical form of ...

Plasticity in the structure and assembly of proteasomes
www.jbc.org/article/S002...

FEBS Press Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids a...

GCN2 in proteostasis: structural logic, signalling networks and disease
febs.onlinelibrary.wiley.com/doi/10.1111/...

Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB
portlandpress.com/biochemj/art...

TAK1 regulates skeletal muscle mass, hypertrophic signaling, and metabolic homeostasis in male and female mice
www.biorxiv.org/content/10.6...

Proteasomal control of transcription factors: mechanisms, regulation and dysregulation - Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences - Regulation of transcription is of key importance for essentially all aspects of biology. Accordingly, transcription factors (TFs) are often subject to rapid...

Proteasomal control of transcription factors: mechanisms, regulation and dysregulation
link.springer.com/article/10.1...

Erk3 deletion drives oxidative adaptations in skeletal muscle Skeletal muscle plays a central role in whole-body energy expenditure and metabolic homeostasis, and improving its mitochondrial function and oxidativ…

Erk3 deletion drives oxidative adaptations in skeletal muscle
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Mouse Models of Muscle Fibrosis: Mechanisms, Methods, and Applications
www.mdpi.com/2227-9059/14...

A network-based atlas of human skeletal muscle aging Skeletal muscle metabolic and physical capacities are influenced by both genetics and load status and decline with age. Recent advances in sequencing have detailed cell types at unprecedented detail; ...

A network-based atlas of human skeletal muscle aging
www.medrxiv.org/content/10.6...

Twisting Paths: The Paradox of Fiber Branching in Muscle Regeneration
www.mdpi.com/1422-0067/27...

PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.

PFKM governs metabolic shifts throughout skeletal muscle differentiation
www.nature.com/articles/s42...

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of...

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Endocrine-metabolic decoupling drives stress vulnerability in dystrophin deficiency
www.biorxiv.org/content/10.6...

Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions
www.biorxiv.org/content/10.6...

FEBS Press Alpha-crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor-β (TGF-β) signaling, enabling target gene transcription...

Resistance-exercise-induced stress intervenes in TGF-β signaling by cooperatively downregulating nuclear αB-crystallin and SMAD4 in human skeletal muscle fibers
febs.onlinelibrary.wiley.com/doi/10.1111/...

Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging Increased muscle entropy, measured by the homeostatic dysregulation index of muscle, reflects fiber disorganization. This accumulation of entropy independently contributes to declines in physical per...

Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging
onlinelibrary.wiley.com/doi/10.1111/...

Top–Down Proteomics of Skinned Human Muscle Fibers Reveals Proteoform‐Resolved Fiber‐to‐Fiber Variability Human skeletal muscle is composed of highly heterogeneous single muscle fibers (multinucleated single cells) that are commonly classified as fast or slow fiber types, yet proteoform-resolved characte...

Top-Down Proteomics of Skinned Human Muscle Fibers Reveals Proteoform-Resolved Fiber-to-Fiber Variability
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Insolubilome profiling defines molecular features that influence protein insolubility with aging Solubility regulates protein function, but how it is governed by aging remains elusive. Here, we utilized mass spectrometry to define the relative com…

Insolubilome profiling defines molecular features that influence protein insolubility with aging
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Therapeutic strategies targeting muscle stem cells in satellite cell-opathies
journals.sagepub.com/doi/10.1177/...

Hb-EGF directs systemic muscle repair Regenerative capacity varies between tissues, species, stages of the life cycle. Regenerative capacity also varies with the magnitude of the injury, even within a single tissue. Vertebrate skeletal mu...

Hb-EGF directs systemic muscle repair
journals.biologists.com/dev/article/...

LXR activation in skeletal muscle cells enhances differentiation and promotes protein synthesis | American Journal of Physiology-Endocrinology and Metabolism | American Physiological Society Skeletal muscle possesses a remarkable capacity for regeneration, which is largely orchestrated by muscle satellite cells (MuSCs), a population of tissue-resident stem cells. Upon injury, these cells ...

LXR activation in skeletal muscle cells enhances differentiation and promotes protein synthesis
journals.physiology.org/doi/abs/10.1...

NSAIDs and muscle hypertrophy: Methodological concerns and alternative interpretations Click on the article title to read more.

NSAIDs and muscle hypertrophy: Methodological concerns and alternative interpretations
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Menopause, Female Sex Hormones, Skeletal Muscle Mass and Muscle Protein Turnover in Humans Sarcopenia describes the loss of muscle mass and function with age. The increase in prevalence of sarcopenia in women appears to coincide with the onset of menopause, which is characterized by large ...

Menopause, Female Sex Hormones, Skeletal Muscle Mass and Muscle Protein Turnover in Humans
onlinelibrary.wiley.com/doi/10.1002/...

Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle - npj Aging npj Aging - Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle

Molecular insight into transcriptome profiling of aerobic exercise induced changes in aged skeletal muscle
www.nature.com/articles/s41...

Human neuromuscular organoids mimic cancer-induced muscle cachexia Chiolerio et al. introduce neuromuscular organoids derived from human-induced pluripotent stem cells as an innovative in vitro platform to model cancer-induced muscle wasting. The organoids recapitula...

Human neuromuscular organoids mimic cancer-induced muscle cachexia
www.cell.com/cell-reports...

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse
www.biorxiv.org/content/10.6...

Growth hormone causes reversible fibrosis in muscle and fat: A study in patients with acromegaly
academic.oup.com/ejendo/advan...