Matteo Guardamagna

Linking neural manifolds to circuit structure in recurrent networks Neural population activity can be described either by low-dimensional dynamics on neural manifolds or by single-neuron selectivities. Using a theoretical approach, Pezon et al. relate these two statis...

I thought this was an exciting new theoretical perspective www.cell.com/neuron/fullt...

University of Utah Health Campus at sunset. Image courtesy of the University of Utah.

📢📢 My lab at @utah.edu is officially open and I'm RECRUITING — especially techs/specialists and postdocs! Our research focuses on the neurobiology of interoception and learning & memory using tools from systems/comp neuro. Please share! 🧠🏔️🏜️

Apply/more info: zimmerman-lab.org#positions

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Awesome, thank you for these two papers! We know that PV cells plays a key role in sustaining the grid pattern in the adult system, I am sure they are essential for the emergence of the attractor architecture. The desync switch probably involves a more complex interplay of sst, pv and exct cells

Thank you Pritish!

Thank you so much!

But we have a lot more to do on this.
Some beautiful work on this topic:
elifesciences.org/articles/78116
www.cell.com/neuron/fullt...
www.nature.com/articles/s41... (review)

Thanks Horst! :) yes an overall increase in firing rates makes everything 'more detectable'. But I think there is also a true increase in the recruitment of inhibitory components across the circuitry, mirroring similar/known network changes in other cortical regions which lead to desynchronization

Thanks! We think there are various 'teaching signals' (which vary in relevance across different days) that help construct the torus. Among these: olfaction, twitching and head scanning. We tackle this topic in more depth in the Discussion

Grazie mille Fabrizio!

Thanks so much!

Thank you!

New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6....

As our lab's first foray into comparative analysis of neural dynamics, I’m super excited about this work! 1/18

Thank you so much Nikolas!!

super useful thread!

Thank you Shaked! :)

Oh fantastic! In rodents this transition also happens throughout the neocortex, albeit at slightly different times/postnatal days depending on the circuit

🤩

Thank you!

Super interesting work - congrats to all! 👏 A wonderful example of how innate circuit structure prepares the brain to represent experience. (Linking to Kant's idea of the innate category of Space)

Thank you Kevin! That's exactly how we are thinking about it :)

Thank you Adrian!

Thanks so much Adrien! 🤩

Grazie mille Flavio! 😊

😍

With an amazing team✨: @erikhermansen.bsky.social, @jocarpenter.bsky.social, @clykken.bsky.social, @benndunn.bsky.social, @edvardmoser.bsky.social, @m-bmoser.bsky.social; @kavlintnu.bsky.social
Supported by Norges forskningsråd, @erc.europa.eu via #KiloNeurons, @embo.org and @kavlifoundation.org

7/7 Take-home message: core computational architectures for spatial cognition are intrinsically self-organized. Navigational experience aligns and anchors them to the external world.

6/7 Similarly, 1D ring-like topologies emerge in the parasubiculum as early as P9, even before head-direction tuning is established⭕️

5/7 What is the role of experience? A second phase begins around P15 when pups start navigating outside the nest. Internally generated toroidal manifolds progressively align with external landmarks, eventually stabilizing into regular grid fields.

4/7 This emergence is abrupt. Between P9 and P11, network activity transitions from synchronized bursts to desynchronized dynamics, driven by a pronounced increase in inhibitory connectivity.