Holmqvist Lab

A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.

Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @mldm.bsky.social @sellinlab.bsky.social in @natgenet.nature.com

www.nature.com/articles/s41...

ProQ prevents mRNA degradation through inhibition of poly(A) polymerase Abstract. The RNA-binding protein ProQ interacts with many transcripts in the bacterial cell. ProQ binding is associated with increased messenger RNA (mRNA

New paper from the lab out now. ProQ prevents polyadenylation to stabilise mRNA in Salmonella.
Fantastic work by Sofia Bergman and Christopher Birk.

As our very first Bluesky post we congratulate Sofia Bergman who according to the Swedish tradition has nailed her thesis! The celebration included a homemade Salmonella cake 😀

In perfect time for the dissertation (14/2) she just had a paper accepted as a Breakthrough Article in NAR. Stay tuned.