The Asbury Centre

Excised DNA circles from V(D)J recombination promote relapsed leukaemia Nature - Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis,...

Research that could change lives: A new paper led by Leeds researchers shows DNA by-products may be 'early warning system' for relapse in childhood leukaemia.

Read it in Nature: bit.ly/41zW927

@cclguk.bsky.social @littleprincesses.bsky.social
@bloodcanceruk.bsky.social @ljrusselllab.bsky.social

Structure of human TRPC5 in complex with the plant nature product (-)-englerin A

We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation".

www.biorxiv.org/content/10.1...

An absolute pleasure to host @thornsesholdlab.bsky.social in Leeds today for an amazing @astburycentre.bsky.social seminar.

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Winners of Best disruptive food and drink business plan at the YES24 competition : The Astbury Centre for Structural Molecular Biology Congratulations to Caffinity Biotech, a team of early-career researchers from the Astbury Centre, on winning "Best disruptive food and drink business plan" sponsored by the Food Consortium Collaborati...

Congratulations to a team of early-career researchers from the Astbury Centre, on winning "Best disruptive food and drink business plan" at the YES24 competition
astbury.leeds.ac.uk/all_news/win...

Done!

Poster of meeting for 28 March 2025

Are you interested in proteins as exciting, dynamic interacting species. Come and join us- March 28th 2025.

Places are limited so please register ASAP at sheena-radford-lab.uk/fida.php. (£25.00 registration only, including excellent catering).

We will add Astbury Centre members to the starter pack, but if we have missed anyone one please do DM us!

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.