Jeremy Dufourt

The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection Influenza virus infections can cause severe complications such as Acute Necrotizing Encephalopathy (ANE), which is characterised by rapid onset pathological inflammation following febrile infection. H...

Our latest collaborative study with the Pasteur Institute and University of Toronto on the role of RANBP2 in #influenza -associated hyperinflammation #AcuteNecrotizingEncephalopathy @aneinternational.bsky.social @ribonucleicacids.bsky.social @irim-life.bsky.social
www.biorxiv.org/content/10.1...

Congrats @maxvcg.bsky.social 🎊

Quand des revues scientifiques deviennent des machines à cash : derrière ce business, des réseaux opaques

Source : L'Express

Thanks, I thought host Lab was not a criteria as describe in the application note but I understand that some scientific strategy exist :-(
Good luck with oral presentation and the hard selection between all these smart candidates.

📜 After two days of hard work, below are the lists of CNRS researcher (CR) and director of research (DR) candidates selected for audition by the Cell Bio/Dev Bio/Evo-Devo section (section 22).
👉 CR auditions are Mar 25-27 at Institut Jacques Monod.
👉 DR auditions are Mar 31-Apr 1 at IBPS (Jussieu).

Wow i am not aware of the scientific policies beyond the selection but some very surprising results. Sad that candidates do not receive an official feedback.

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

Sensation is dispensable for the maturation of the vestibulo-ocular reflex Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life....

Big paper from @paigel.bsky.social in our lab:

Sensory feedback is always crucial for proper development, right? Wrong!

Crazier still, the motor system is the slowest part of a developing reflex circuit!

Surprises abound in this bluetorial c’mon along….

www.science.org/doi/10.1126/...

1/19

Finally! The Hydroxychloroquine study by Gautret et al. has been retracted. I wrote a critical post about it in March 2020, days after it came out.

scienceintegritydigest.com/2020/03/24/t...

Control of Epithelial Tissue Organization by mRNA Localization mRNA localization to specific subcellular regions is common in mammalian cells but poorly understood in terms of its physiological roles[1][1]–[6][2],[7][3]. This study demonstrates the functional imp...

Control of Epithelial Tissue Organization by mRNA Localization
#spatialbiology #RNAbiology
From the Mili's lab
www.biorxiv.org/content/10.1...

Heartbeat of an early zebrafish embryo. Credit to Drs. Fengzhu Xiong & Sean Megason @harvardmed.bsky.social. #ZebrafishZunday 🧪

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.

www.nature.com/articles/nbt...

Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila In some cases, non-genetic information can be inherited across generations. Fitz-James et al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They show that physical contact between regions of DNA within the cell is able to trigger the histone modification H3K27me3 to become heritable.

Excited to share my new paper implicating the 3D genome in epigenetic inheritance. We show that chromatin contacts are able to trigger epimutation in Drosophila. I'm very thankful for the support of Giacomo Cavalli, @psarkies.bsky.social and to all others involved!

www.cell.com/molecular-ce...

It's that time of year. Confocal + Christmas = Xmas Tree, Ymas Tree, and our favorite Zmas tree. #microscopy #confocal #imaging

A microRNA is the effector gene of a classic evolutionary hotspot locus In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...

Our miRNA story is now in @science.org ! We found a microRNA, not a protein, that finally solved a long-standing evolutionary mystery of wing coloration in butterflies and moths. (1/n)
www.science.org/doi/10.1126/...

G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation Parker et al. demonstrate that some proteins responsible for organizing ribonucleoprotein granules can chaperone intermolecular RNA-RNA interactions in addition to their role in scaffolding. These findings cement RNA-RNA interaction networks as a key component of granules, highlighting the need to further explore the regulation of RNA dynamics within granules.

G3BP1 promotes intermolecular RNA-RNA interactions during #RNA condensation
#RNAsky

www.cell.com/molecular-ce...

Amazing scientific vulgarisation job by Lea Bellec. If you need scientific illustration She is the one.

#TEsky #RNASky #RNAbiology

Diagram of tests shaping--myoblasts migrate onto the testis and then elongate as circumferential muscle

@maikbischoff.bsky.social uses the fruit fly testis as a model of organ sculpting. The adult testis is a long spiral shaped tube encased in circumferential muscle, but at the start it is almost spherical without surrounding muscles. During pupation muscle precursors migrate onto the testis 2/n

Picture of a male (top) and female (bottom) zebrafish. Notice the male is more yellow and streamlined. The female is more white and appears larger as it carries oocytes/eggs.

Did you know #zebrafish can change sex as adults? Females that no longer produce oocytes can readily convert to a male, both phenotypically and behaviorally. #ZebrafishFunFacts 🧪

I posted this some time ago on the abandoned platform, but maybe it’s worth advertising here as well:

I’m hiring a post-doc (18 months) for our newly established group at the Institute of Evolutionary Biology in Warsaw.

Apply by 15.12.2024.
More details here: euraxess.ec.europa.eu/jobs/283654

Here are two covers proposals for the current Cell issue, but it didn't make it. I love these renders because they are just data, nothing else! Congrats to @merlinlange.bsky.social & @loicaroyer.bsky.social ! #dataviz #sciart 🐡 🧪 Data imported and rendered in #houdini @sidefx.bsky.social

Controlling Transcription Elongation and Termination: More Than a Means to An End

A special JMB issue on Transcription elongation and termination with really great reviews including @triggerloop.bsky.social @voslab.org @lucas.farnunglab.com

www.sciencedirect.com/science/arti...

Hello everyone! Happy to introduce the Genetics of Host-Microbe Interactions lab. We are using Drosophila to study host-microbe and microbe-microbe interactions.
www.mpiib-berlin.mpg.de/1946812/Gene...

Wow! A method for clonal lineage tracing and cell fate modulation across early development...in vivo!

the thing is, they didn't even try to link this work to miRNA, circRNA, or lncRNA...

Non-native English speakers need 50% more time to write a paper

When they do, they face a 2.5 times higher chance of being rejected because of language

journals.plos.org/plosbiology/...

Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage found widespread in nature. Ribozyme cleavage generates distinct 2′,3′-phosphate and 5′-hydroxyl termini that r...

This week #ScienceMagazine Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies #URochesterResearch @urochester.bsky.social www.science.org/doi/10.1126/...