ACR Journals

Unveiling Endotypes in Systemic Lupus Erythematosus Through Multi-Omic Analysis: Insights into Cardiovascular and Renal Complications. A graphical abstract

Multiomic profiling reveals distinct molecular endotypes linked to cardiovascular & kidney complications in SLE. Findings support potential opportunities for precision risk stratification

Arthritis & Rheumatology
doi.org/10.1002/art....

Safety of Immune Checkpoint Inhibitors in Cancer Patients With Preexisting Autoimmune Vasculitis Objective Immune checkpoint inhibitors (ICIs) are effective cancer therapies but often cause serious immune-related adverse events (irAEs). Patients with preexisting autoimmune diseases, including v...

Retrospective study and lit review evaluated frequency, severity, and outcomes of vasculitis flares in cancer patients with pre-existing vasculitis treated with ICIs, and found about 1/3 had a vasculitis flare following ICI therapy

ACR Open Rheumatology
doi.org/10.1002/acr2...

Immune checkpoint inhibitor-associated inflammatory arthritis. Graphical abstract created using BioRender

New Immunology for the Rheumatologist case-based review: This state-of-the-art review summarizes our current understanding of immune checkpoint inhibitor associated inflammatory arthritis and promising avenues for future research

Arthritis & Rheumatology
doi.org/10.1002/art....

Relationship between rs26232 genotype, PAM expression and RA. (A) Annotation of genes in the locality of rs26232 (located within the first intron of MACIR). (B) Relative expression levels of MACIR, PAM, GIN1 and PPIP5K2 in RASFs (n=33) by rs26232 genotype. Tested by Kruskal–Wallis test. (C) Association of rs26232 genotypes with PAM mRNA levels in human dermal fibroblasts, cerebellum and whole blood in GTEx data. Rheumatoid synovial PAM mRNA levels and clinical activity in the PEAC study data; (D) levels correlate with pathotype, and inversely with measures of systemic inflammation; (E) CRP (F) ESR, and with ultrasound assessed synovitis including (G) synovial thickness (ST) and (H) blood flow. (I) scRNAseq in AMP2 data showing subsets for cell lineages within the synovium. This reveals high level expression in all fibroblasts subtypes with lower levels in endothelial cells and minimal expression in leucocytes

Genetically determined low levels of peptidylglycine alpha-amidating monooxygenase in RA synovial fibroblasts resulted in increased tissue damage. Reduced amidation of adrenomedullin caused increased invasion in synovial fibroblasts & shift toward M1 Mφ

doi.org/10.1002/art....
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Longitudinal score analysis for those patients with data for all four time points (n = 15). The majority of patients show improvement; however, two patients experience a large increase in score (>4 between the two time points; blue and red), one resulting in death.

Evaluating clinical use of the Juvenile Systemic Sclerosis Severity Score (J4S) using data on 58 patients with juvenile-onset systemic sclerosis from the National Registry for Childhood Onset Scleroderma over up to 3-year follow-up

ACR Open Rheumatology
doi.org/10.1002/acr2...

Integrating Patient‐Reported Quality Measures in SLE: Development of the American College of Rheumatology Implementation Guide Objective To support high-quality, patient-centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence-based measures incorporating clinical a...

Interviews w/ rheumatologists & support staff examined implementation of ACR-recommended PROMs in SLE clinical care & identified barriers & facilitators to collecting these measures in routine practice
doi.org/10.1002/acr....

🔗SLE Quality Measures Implementation Guide slequalitymeasures.kotobee.com

TWIST1-Mediated Induction of AEBP1 in Fibroblast-like Synoviocytes Activates TGF-β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis. Graphical abstract created using BioRender

How do pathogenic fibroblasts drive synovial hyperplasia and pannus formation in RA? New paper uncovers crucial role of the TWIST1-AEBP1-POSTN axis in RA progression. Targeting this axis could be a promising therapeutic strategy for mitigating RA

Arthritis & Rheumatology
doi.org/10.1002/art....

Biological/targeted synthetic DMARDs do not arrest bone loss in patients with rheumatoid arthritis: a long-term multicenter observational study. Graphical abstract created using BioRender

In Japanese patients with rheumatoid arthritis, bone loss was not prevented despite treatment with b/tsDMARDs. In a multicenter long-term study (2,489 person-years; median follow-up 3.1 years), osteoporosis management remained essential in RA

Arthritis & Rheumatology
doi.org/10.1002/art....

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ-R) and its risk factors among long-term HCQ users with rheumatic diseases through a syst...

Systematic review and meta-analysis estimated pooled prevalence of HCQ-retinopathy was 5% between 2008 to 2023, and cumulative incidence rose over time. Patients receiving HCQ >5 mg/kg/day of actual body weight had 4-fold higher risk

Arthritis Care & Research
doi.org/10.1002/acr....

Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus. Graphical abstract created with BioRender

Longitudinal single-cell study of B cell depletion therapy in lupus tracked immune changes up to 15 months after rituximab treatment, revealing shifts in B cell subsets, transient repertoire remodeling, & broader transcriptional effects across T cell populations

A&R
doi.org/10.1002/art....

Arthritis & Rheumatology
doi.org/10.1002/art....

Dual-Targeting BCMA-CD19 CAR-T Cell Therapy in Systemic Lupus Erythematosus: Single-Cell and Immune Repertoire Analysis Reveals Mechanisms of Immune Reconstitution. Graphical abstract created using BioRender

Exploratory single‑cell RNA-seq study of 5 SLE patients before and after BCMA-CD19 dual-targeting CAR-T cell therapy showed broad remodeling of peripheral B-cell compartment and reduced IFN signaling when compared with public data of SLE patients treated with CD19 single-targeting CAR-T therapy

Formal and informal social care in people with Rheumatic and Musculoskeletal diseases: a cross-sectional multicentre survey. A graphical abstract

Cross-sectional survey identified how many patients with rheumatic and musculoskeletal diseases received social care, who provided it, and the frequency & duration of care in two disparate regions in the UK

Arthritis Care & Research
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Standardized Interoperable Data Collection for Myositis Research: Developing Expert Consensus on Common Data Elements for Myositis Outcome Measures Background Recent progress has been made in developing validated myositis outcome measures. However, critical deficiencies remain for data standardization across myositis registries. While the Natio...

Multispecialty expert panel developed computable myositis-specific common data elements (CDEs) for myositis outcome measures

AC&R
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

CDEs are in process of being submitted to NIH CDE repository, and REDcap data dictionaries are planned

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NEW EPISODE! We explore how the gut microbiome may shape symptoms in systemic sclerosis. Learn how microbiome-derived metabolites like short-chain fatty acids could play a key role in disease development & future treatment
🎙️ LISTEN → acr.tw/4cWNSMj

Anti-CD146 autoantibodies assoc with occupational dust exposure in SSc
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Weekly recap in ACR Journals banner - ACR Open Rheumatology cover

New this week in ACR Open Rheumatology:

RNA-seq study of children with juvenile scleromyositis overlap
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Clinical characteristics of 7 children with juvenile DM who later developed SpA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease Click on the article title to read more.

Review: The Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Weekly recap in ACR Journals banner - Arthritis Care & Research cover

Posted this week in Arthritis Care & Research

Algorithm to identify prevalence of SLE in Australia
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Estimating minimal important change for pain & function outcomes in guided exercise for hip OA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

CD14 as regulator of synovial inflammation in post-traumatic OA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

TWEAK/Fn14 signaling drives oxidative cardiac injury in SLE
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Inosine-triphosphate-pyrophosphatase activity predicts response to MTX for JIA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Multiomic blood profiling identifies signature linked to long-term organ damage in SLE
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Prognosis and outcome of stenotic large vessel involvement in GCA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

High baseline IL-10 predicts response to abatacept + MTX treatment for RA
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Weekly recap in ACR Journals banner - Arthritis & Rheumatology cover

Get caught up on the great studies now online in A&R:

H19 upregulated in SSc skin and correlated with profibrotic markers
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Luciferase immunoprecipitation performance for myositis autoantibodies
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Anti-CD146 Autoantibodies: The First Biologic Markers Associated With Occupational Exposure in Systemic Sclerosis. Graphical abstract created using BioRender

ELISA testing revealed anti-CD146 autoantibodies were more prevalent in patients with systemic sclerosis than controls. Anti-CD146 autoantibodies were also associated with occupational dust exposure

ACR Open Rheumatology
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype Objective Juvenile dermatomyositis (JDM) is a rare childhood inflammatory myopathy, whereas spondyloarthritis (SpA) is an inflammatory arthropathy characterized by enthesitis and peripheral or axial.....

Retrospective study evaluated clinical characteristics of 7 children with juvenile dermatomyositis who later developed spondyloarthritis

ACR Open Rheumatology
https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr2.90001

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis. Graphical abstract created using BioRender

RNA-seq study of children with juvenile scleromyositis revealed unique clinical characteristics, including autoantibody profiles, organ involvement, and peripheral blood transcriptomic signatures compared to juvenile SSc and DM

ACROR
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

TWEAK/Fn14 signaling drives oxidative cardiac injury in systemic lupus erythematosus: Evidence from patient biomarker studies, lupus mouse models, and cardiomyocyte assays. A graphical abstract

Patients with SLE can quietly accumulate cardiovascular damage. New study reveals the TWEAK/Fn14 axis as key molecular link driving oxidative myocardial injury, even before symptoms appear. Targeting this pathway may enable early cardiac protection
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Arthritis & Rheumatology
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

CD14 plays a critical role in pain and inflammation across multiple models of post-traumatic osteoarthritis. Graphical abstract created using BioRender

This study showed CD14 to be a key regulator of synovial inflammation after joint injury. Blocking CD14 reduced inflammatory immune cell infiltration & alleviated pain across OA models, representing a potential new therapeutic path for targeting innate immune signaling in post-traumatic OA

Protein signatures elevated in patients with SLE. (A) Correlation matrix displaying intercorrelation between SOMAScan 1.1K array protein measurements positively altered in patients with SLE vs HC with Mann–Whitney adjusted P<0.10, AUC>0.5. The direction of protein levels in SLE vs HC, 21-IFNGS high patients, severe patients as determined by SELENA-SLEDAI or SDI, and protein signature-positive participants are displayed in the color bar on the right. (B) Bar chart displaying proportion of cohort negative for all four signatures (5/87 patients – 5.7%) or positive for at least one signature (2 SD from HC mean used as threshold; 82/87 patients – 94.3%). (C) Scatter box plots displaying elevation of protein signatures in IFNGS-high and IFNGS-low SLE vs HC, Mann–Whitney U test used to measure significance of differences between groups. 21- IFNGS, interferon 21-gene signature

Integrated multiomic blood profiling identified an immune cell priming signature linked to renal involvement and long-term organ damage in SLE, outperforming conventional clinical measures in identifying patients at high risk

A&R
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...