Fig 4 says a lot: Blood collection tubes impact release of immune cell RNA over time.
10.03.2026 07:44
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Fig 4 says a lot: Blood collection tubes impact release of immune cell RNA over time.
Comparing an old-school single data point measurement with one that captures 1000+ features on instruments that cost 1000x more. A lot of housekeeping possibilities … but good that more data also means better insights.
A Meta-Analysis of 515 Human Proteomes Defines the Core Composition and Contaminants of Plasma Extracellular Vesicles isolates www.biorxiv.org/cont...
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#proteomics #prot-preprint
SciLifeLab seeks nominations for the next Campus Solna Director! 🧪
Campus Solna brings together the collective strength of @ki.se, KTH and @stockholm-uni.bsky.social, creating a unique interdisciplinary environment.
Read more & nominate ↓
www.scilifelab.se/career/scili...
Not sure I understand the post correctly, but we aim to establish a reference that can be used by everyone to avoid method or even assay specific standards: www.nature.com/articles/s41...
Postdoc position available! Are you a highly motivated biochemist or analytical chemist with proven expertise in proximity labelling, mass spectrometry and proteomics? Then join our team! www.uu.nl/en/organisat...
🚨 New preprint from the lab!
We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...
Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
🚨 A new open-access resource of @proteinatlas.bsky.social
A human pan-disease🩸 atlas of the circulating proteome
👉 www.proteinatlas.org/humanproteom...
📖 www.science.org/doi/10.1126/...
🤩 @buenoalvez.bsky.social and many more!
@kawresearch.bsky.social
@scilifelab.se
@kthuniversity.bsky.social
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - probably the currently most comprehensive comparison of plasma proteomics platforms!
Congrats to Sara and her team!
www.nature.com/articles/s42...
Not yet, setting this up for plasma seems complex enough for now. We touched upon other fluids towards the end, so if this works, one can imagine to expand into urine, CSF, WB or DBS…
Looking forward to seeing those observations!
Can you comment on whether the ratio between glyco- and non-glycopeptides changes with NP enrichment (as compared to neat samples)?
Interesting! Did you also try to first enrich of glycoproteins or remove the modifications prior to particle enriched MS? Would be curious to understand the impact of glycosylation on such a workflow.
We think it will be a win if we can convince the community to add 3-6 extra samples to theirs and "invest" into such connecting analyses. Once have data from our first pilot, we can reshape such schemes with input from you and others"
While these can serve as starting point for future refinements, many (pre-analytcial) aspects appeared that compliactes this effort. Obtaining donor-derived matrial from certain populations, for example, might create a bias, and producing serveral variants of one protein might still be too costly.
Thanks Karsten - even though we briefly mention how single-nucleotide polymorphisms or sequence variants influcnce protein measurements using affinity-based tests and MS, this aspect is certainly underdeveloped for now. We tried to focus on how we could overcome buidling a first set of references.
🚨 Exciting to share our recent global team effort on "A standardized framework for circulating blood proteomics" that just came out in Nature Genetics: rdcu.be/eHK4v.
Metformin treatment affects the circulating proteome (such as GDF15) in persons with and without diabetes.
Great outcome of a close collaboration of the IMI-DIRECT, IMI-RHAPSODY and SCAPIS-Wellness consortia, studying multiple cohorts by advanced proteomics.
www.sciencedirect.com/science/arti...
Differences between mouse and humans are expected but longitudinal effects hopefully follow more common mechanisms.
We (+ others) have compared proteomes in capillary and venous samples - differences driven by penetrated tissues (skin) and blood preparation (whole blood vs plasma).
More soon…
Can you elaborate why it doesn’t make sense to you?
We assume equilibrium in blood and no gradient due to sampling location or distance to an organ. Total blood volume is ~ 2 mL and sensitivity is far from 1 protein per 1 uL.
You can even browse the data to search for your favorite longitudinal protein signature
mouse-dbs-profiling.serve.scilifelab.se/app/mouse-db...
@scilifelab.se @kthuniversity.bsky.social
@ki.se
Are you curious about blood microsampling to monitor changes in the circulating proteome?
Then check our team science study recently published in @diabetologiajnl.bsky.social where we study the effects of virus induced immune response and disease onset.
link.springer.com/article/10.1...
🚨Industry PhD position on advanced (proteo)omics data-driven analyses to study the molecular effects of #medication with #Pfizer.
Apply 👉 www.pfizer.com/about/career... to join the SciLifeLab & Wallenberg National Program for Data-Driven Life Science.
@scilifelab.se @kthuniversity.bsky.social
Explore our new preprint featuring novel data generated on the Nautilus Proteome Analysis Platform! The preprint covers how we use Iterative Mapping to quantify tau proteoforms at the single-molecule level:
www.biorxiv.org/content/10.1...
#Proteomics #Neuroscience #Proteoforms #AlzheimersDisease
Congratulations Dr Vincent from the @mannlab.bsky.social 🎓
Epitope Effect Prevalence in Affinity-based pQTL studies https://www.biorxiv.org/content/10.1101/2025.06.20.660695v1
Illumina picks up proteomics developer SomaLogic from Standard BioTools for $425M | www.fiercebiotech.co...
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#proteomics #prot-article
Saint Malo
Back from #EUPA2025 in a Saint Malo and am so impressed by the ECR talks, and so happy we gave them to opportunity to be on stage and shine ✨! Keep up the great work! You are the future of #proteomics…
Also thanks to my excellent session co-chair @maurinefucito.bsky.social for making this fun!
Pretty tidy and refreshing for those who dare.