Craig Gedye

Thank you. Agree, PSMA and PSA are just phenotypic markers that are demonstrably dispensable as mPC evolves under environmental and treatment selective pressure.

Thank you. Could you expand? PSA response vs PSMA response - is one better?

Writers' Week under threat of collapse as list of writers leaving nears 100 - News | InDaily, Inside South Australia A multitude of high-profile authors has joined the flood of names demolishing the Writers' Week lineup.

It seems about half to two-thirds of the writers have withdrawn so it looks like it will shorter than an Ashes series... www.indailysa.com.au/news/just-in...

Record heatwave no match for solar-soaked power grid Energy demand reached its highest level on record on Wednesday during this week’s heatwave, but rooftop solar has taken the stress off.

If anyone argues “But what about baseload?” when you talk about renewable energy, please reference this article www.afr.com/policy/energ...

The kids have (sadly) aged out of Lego advent calendars, so thanks again to @FreseniusKabi for shipping their IV saline in such strong and repurposable cardboard boxes!

Prophylactic gabapentin during head and neck cancer therapy: a systematic review and meta-analysis This review was designed to compile the currently available evidence on the prophylactic use of gabapentin in the head and neck cancer patient population. A systematic search was conducted of PubMed, Web of Science, and Google Scholar to identify ...

Our #HNSCC docs have implemented 'prophylactic gabapentin' based on meta-analysis showing reduced opiates and less weight loss during #chemo #radiation pmc.ncbi.nlm.nih.gov/articles/PMC...

Inferred prospective evidence from other settings? E.g. elective surgery pubmed.ncbi.nlm.nih.gov/35418085/ and peri-treatment for HNSCC www.redjournal.org/article/S036...

Grateful to have overheard a colleague talking about "preemptive pregabilin". Offered immediate upfront pregabilin for a patient with florid and painful shingles, with rapid improvement of pain. No prospective trials but interesting case series. 10/10 would Rx again. journals.lww.com/ejanaesthesi...

Fifteen Years

Our goal for every person, every day xkcd.com/3172/

Don't Do Me Like That: Promoting Respectful Language in Oncology Research | JCO Oncology Practice

"Beyond respectful language, which is the minimum requirement… [this study] reinforces the broader message about maintaining respect for patients as individuals & ensuring that this is reflected in our words & deeds."
 
@ascocancer.bsky.social
@jco-asco.bsky.social @ethicsdoctorp.bsky.social

It's on my bookshelf as well, and perhaps one of the only books I actually open with any regularity.

When life gives you sour mandarins...

well done and great work congrats to you and @asharpmedonc.bsky.social the team

😂

Engineering a Novel T‐Cell Epitope‐Based Vaccine Targeting PRAME in Cancer Immunotherapy PRAME, a cancer/testis antigen, is often expressed abnormally in various cancers, making it a hopeful candidate for cancer immunotherapy. This study aimed to create a vaccine targeting PRAME using im...

Agreed. Not just HLA-A2 restricted academic.oup.com/immunotherap... maybe an efficient vaccine? onlinelibrary.wiley.com/doi/abs/10.1...

PRAME now useful as a routine phenotype IHC diagnostic marker as well, so many labs will be able to detect in routine care

NY-ESO-1?

Thanks so much to @anzuptrials.bsky.social for helping us starting putting the NZ into ANZUP - great ideas shared on the day for clinical trials for people with GU and prostate cancers in NZ and maybe also AUS as well!

Fantastic to have this critical advice for older people with cancer - thank you @crisbergerot.bsky.social @bogda-koczwara.bsky.social and team

And the infographic Research Summary as well www.nejm.org/do/10.1056/N.... Clinical trials only become healthcare if you communicate the result. Ringer's no better than saline BTW.

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

The Whitlams - Blow Up The Pokies (Official Video) YouTube video by thewhitlamsofficial

One more of my votes for the #Hottest100 #TripleJ in the #Hottest200 today... The Whitlams - Blow Up The Pokies www.youtube.com/watch?v=7B49..., still as relevant today www.theguardian.com/australia-ne...

Question remains, is the abscopal effect real? Or is #RT just additive? Certainly evidence for modifying TME, intriguing data for WNT-mt patients when adding #radiotherapy to #PD1 #immunotherapy, but the idea of #RT being a 'vaccine', expanding the immune repertoire, is shown in just 1-2 patients.

The Renal IGW is fast approaching. Concept submissions close in 1 week!
Register your attendance here anzup.org.au/idea-generat...
@craiggedye.bsky.social

Two opinions that to my surprise are either unpopular or not widely held:
1. The control arm of a randomised trial should be best standard of care.
2. A PFS benefit against an inactive comparator is not a major advance, if progressive disease is required for eligibility.

FDA draft guidance outlines appropriate use of tissue biopsies in clinical trials When are tissue biopsies really needed in clinical trials of medical products? Draft guidance from the US Food and Drug Administration (FDA) offers recommendations for weighing the risks and benefits ...

3. Despite ASCO (ascopubs.org/doi/full/10....) and FDA (www.raps.org/news-and-art...) statements that it is unethical to stick large needles into people suffering cancer, many sponsors seem to want to shove large needles into people suffering cancer; for what? To make pretty pictures for a poster?

Great kickoff to clinical trials workshop #ANZUP25 — #MelissaLeMesurier w patient perspective and #ChrisGianacas biostats on collaborative efforts for clinical trials. Same global themes for clinical trial development. @anzuptrials.bsky.social @craiggedye.bsky.social @profiand.bsky.social

Tremendous insights with immediate patient impact; using genomic data we can collect routinely from today's patients, we may be able to predict upfront resistance, rather than subject people to 3-4 cycles of chemo, and we might also be strategic if we know people have sensitive cancers - bravo!

Bravo. Fantastic news.

Introducing the Medical Evidence Project And the quest to make less dead people

Friends, I have news.

It is very good news.

You'll just have to read it, I'm afraid.

jamesclaims.substack.com/p/introducin...