BaladoCritique : club de lecture médical

Chez les sujets présentant un risque cardiovasculaire élevé, atteints d’athérosclérose ou de diabète, mais n’ayant jamais subi d’infarctus du myocarde ou d’accident vasculaire cérébral, est-ce que le ...

Notre article-résumé sur l'essai clinique VESALIUS-CV est maintenant publié dans @revmedinterne.bsky.social.
Bonne lecture !
#MedSky #EndoSky #CardioSky #EBM @asmiq.bsky.social @usherbrooke.bsky.social
www.sciencedirect.com/science/arti...

We are pleased to introduce a new Rapid Resource: VTE Diagnosis and Management for the Primary Care Provider — a concise 2-page guide covering diagnosis pathways, treatment strategies, and practical clinical pearls for frontline care.

📘 Access the full Rapid Resource: acforum.org/r/I1Xdhf7nMz...

Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study Objectives To investigate whether initiation of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with both reduced risks of incident alcohol, cannabis, cocaine, nicotine, opioid, and ot...

"Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study."
Publié ce jour dans @bmj.com.
#MedSky
www.bmj.com/content/392/...

Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial Baxdrostat significantly reduced 24 h ambulatory SBP versus placebo in patients with resistant hypertension, providing further evidence of the potential of aldosterone synthase inhibition for treatmen...

"Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial."
Publi ce jour dans @thelancet.com.
#MedSky
www.thelancet.com/journals/lan...

Adult obesity and risk of severe infections: a multicohort study with global burden estimates Adult obesity is a risk factor for infection-related hospitalisations and mortality across diverse pathogen types, populations, and baseline clinical profiles, with evidence suggesting that approximat...

"Adult obesity and risk of severe infections: a multicohort study with global burden estimates."
Publié ce jour dans @thelancet.com.
#MedSky #IDSky
www.thelancet.com/journals/lan...

Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction | NEJM The preferred timing of treatment of nonculprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) remains uncertain. A comparison of immediate percutaneous coronary interv...

“Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction.”
Publie ce jour dans le @nejm.org.
#MedSky #CardioSky
www.nejm.org/doi/full/10....

Finerenone in Type 1 Diabetes and Chronic Kidney Disease | NEJM The nonsteroidal mineralocorticoid receptor antagonist finerenone has been reported to improve kidney and cardiovascular outcomes in persons with type 2 diabetes and chronic kidney disease (CKD). T...

“Finerenone in Type 1 Diabetes and Chronic Kidney Disease.”
Publié ce jour dans le @nejm.org.
#MedSky #EndoSky
www.nejm.org/doi/full/10....

Mobile Chat Messaging for Smoking Relapse Prevention This randomized clinical trial examines the effectiveness of mobile chat messaging vs generic text messaging for relapse prevention among individuals who recently quit smoking and had abstained for 3 ...

"Mobile Chat Messaging for Smoking Relapse Prevention."
Publié en mars dans @jamainternalmed.com
#MedSky jamanetwork.com/journals/jam...

"ACG Clinical Guideline: Hepatic Encephalopathy."
Publié en mars dans Am J Gastroenterol.
#MedSky #LiverSky #GastroSky
journals.lww.com/ajg/fulltext...

State-of-the-Art Review: Chagas Disease—an Enduring Challenge Chagas disease remains the most significant neglected tropical disease in the Western Hemisphere. In this review, we examine critical aspects of patient ca

"State-of-the-Art Review: Chagas Disease—an Enduring Challenge."
Publié en février dans Clinical Infectious Diseases.
#MedSky #IDSky
academic.oup.com/cid/article/...

Illustration of IgA Nephropathy pathophysiology from JAMA. Four-hit hypothesis shows: 1) Aberrant IgA1 production; 2) Gd-IgA1 entering circulation; 3) Immune complex formation; 4) Complex deposition in glomerulus. Published online January 26, 2026.

IgA nephropathy is the most common cause of immune-mediated glomerular disease worldwide.

📄 This Review summarizes the pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis of primary IgA nephropathy in adults.

ja.ma/47bIhht

Le prochain balado de BaladoCritique : club de lecture médical, portera sur l'essai clinique ADJUST-DVT, publié dans le
@jama.com en février, sur les D-Dimères ajustés pour l'âge dans la thrombose veineuse profonde.
À suivre !
#MedSky

The 🆕 ACC/AHA Guideline for the Evaluation & Management of Acute Pulmonary Embolism (PE) in Adults is a de novo document offering comprehensive, evidence‑based recommendations for the evaluation, management & follow‑up of adults w/ acute PE.

Read more: https://bit.ly/4aE5gmi #ClinicalGuidelines

Tecovirimat for the Treatment of Mpox | NEJM Tecovirimat is approved for smallpox treatment under the Food and Drug Administration Animal Rule on the basis of efficacy in nonhuman primate models of mpox (previously known as monkeypox). Howeve...

“Tecovirimat for the Treatment of Mpox.”
Publié ce jour dans le @nejm.org.
#MedSky #IDSky
www.nejm.org/doi/full/10....

Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges | NEJM Randomized trials of long-acting injectable antiretroviral therapy (ART) in persons with human immunodeficiency virus (HIV) who face challenges with adherence to oral medication are lacking. We con...

“Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges.”
Publié ce jour dans le @nejm.org.
#MedSky #IDSky
www.nejm.org/doi/full/10....

A flowchart titled 'Management of Restless Legs Syndrome'. It outlines steps from initial diagnosis to treatment based on serum ferritin/TSAT levels and symptom frequency, including iron, gabapentinoids, or other combined therapies if needed.

Restless legs syndrome (RLS), a sleep-related movement disorder, is present in approximately 3% of adults worldwide.

📄 This Review summarizes the pathophysiology, epidemiology, risk factors, diagnosis, treatment, and prognosis of #RestlessLegsSyndrome.

ja.ma/4rB7EBD

2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical... AIM The “2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease” provides recommendations to guide clinicians on the evaluation and treatment of adult patien...

"2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines."
Publié ce jour dans Circulation.
#MedSky
www.ahajournals.org/doi/full/10....

New! 🎙️🩺🎧 #515 Primary Aldosteronism, A Deep Dive: Easy on the Salt! 🧂⬇️

Hypertension is everywhere and primary aldosteronism is a common (and often missed 👀) cause. Join us with @anandvaidya17.bsky.social of Brigham and Women’s Hospital

Cost-effectiveness of sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists for patients with high cardiovascular risk and type 2 diabetes in Canada Background: Diabetes Canada and the Canadian Cardiovascular Society recommend that patients with type 2 diabetes and cardiovascular disease, renal disease, or multiple cardiovascular risk factors begi...

"Cost-effectiveness of sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists for patients with high cardiovascular risk and type 2 diabetes in Canada."
Publié ce jour dans @cmaj.ca
#MedSky #EndoSky
www.cmaj.ca/content/198/...

Menopausal hormone therapy and long term mortality: nationwide, register based cohort study Objective To assess whether menopausal hormone therapy increases the risk of all cause mortality. Design Nationwide, registry based cohort study. Setting Denmark. Participants Danish women born bet...

"Menopausal hormone therapy and long term mortality: nationwide, register based cohort study."
Publié ce jour dans @bmj.com.
#MedSky
www.bmj.com/content/392/...

Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials Objective To identify which drugs are effective at preventing delirium after surgery in adults over 60 years of age and estimate the effects on morbidity and mortality. Design Systematic review and n...

"Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials."
Publié ce jour dans @bmj.com.
#MedSky
www.bmj.com/content/392/...

Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial In this trial involving Chinese patients with ischaemic stroke due to basilar artery occlusion, tenecteplase within 24 h after stroke onset improved functional outcome compared with standard medical t...

“Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial.”
Publié ce jour dans @thelancet.com.
#MedSky #NeuroSky
www.thelancet.com/journals/lan...

Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk: A Target Trial Emulation Study: Annals of Internal Medicine: Vol 179, No 2 Background: Whether statins benefit patients with type 2 diabetes mellitus (T2DM) with low predicted 10-year cardiovascular risk is uncertain. Objective: To evaluate the effectiveness and safety of st...

"Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk: A Target Trial Emulation Study."
Publié en février dans @annalsofim.bsky.social.
#MedSky #EndoSky
www.acpjournals.org/doi/10.7326/...

Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma | NEJM In a phase 1–2 trial, teclistamab, a bispecific antibody targeting CD3 on T-cell surfaces and B-cell maturation antigen on myeloma cells, showed durable responses in heavily pretreated patients wit...

"Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma."
Publié ce jour dans le @nejm.org
#MedSky www.nejm.org/doi/full/10....

Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years | NEJM Five-year data from the PARTNER 3 trial showed that among low-risk patients with severe, symptomatic aortic stenosis, outcomes were similar among patients who had undergone transcatheter aortic-val...

« Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. »
Publié ce jour dans le @nejm.org.
#MedSky #CardioSky
www.nejm.org/doi/full/10....

European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases – Editor's Choice The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with descending thoracic and thoraco-abdominal aortic pathologies, in succession to...

"European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases."
Publié en février dans European Journal of Vascular and Endovascular Surgery.
#MedSky
www.ejves.com/article/S107...

Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association | Circulation Premenopausal women presenting with acute coronary syndrome (ACS) are a unique and often underrecognized patient population. Although they are traditionally considered at lower cardiovascular risk tha...

"Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association."
Publié ce jour dans Circulation.
#MedSky #CardioSky @ahajournals.bsky.social www.ahajournals.org/doi/full/10....

Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance:

"Transthyretin Cardiac Amyloidosis Evaluation and Management: 2025 ACC Concise Clinical Guidance."
Publié en février dans JACC.
#MedSky #CardioSky
www.jacc.org/doi/10.1016/...

EASL Clinical Practice Guidelines on vascular diseases of the liver Vascular diseases of the liver include portal vein thrombosis (with or without cirrhosis), portosinusoidal vascular disorder, Budd-Chiari syndrome, sinusoidal obstruction syndrome, non-obstructive sin...

"EASL Clinical Practice Guidelines on vascular diseases of the liver."
Publié en février dans Journal of Hepatology.
#MedSky #LiverSky
www.journal-of-hepatology.eu/article/S016...

AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review Although most patients with chronic constipation respond to medical therapy, a subset experiences refractory constipation (RC), which poses unique diagnostic and therapeutic challenges. Because RC is ...

"AGA Clinical Practice Update on Evaluation and Management of Refractory Constipation: Expert Review."
Publié en février dans Clinical Gastroenterology and Hepatology.
#MedSky #GastroSky www.cghjournal.org/article/S154...