In today’s article, @kingsioppn.bsky.social Professor Cathryn Lewis @cathrynlewis.bsky.social discusses current evidence on the efficacy of #antidepressants and how research should move forward to support #precisionmedicine approaches in #mentalhealth.
www.inspirethemind.org/post/underst...
Outdoor cafe table with laptop and coffee cup
Autumns has arrived - the @kingsioppn.bsky.social campuses are buzzing with new students but still sunny and mild enough for an early morning coffee outside at Ortus.
If your Monday morning is challenging, this post is a reminder of positive changes over the last 10 years.
From cancer treatment to music access to dresses-with-pockets
Hang in there amid the turmoil.
🚨Come work with us!🚨 Open post for Clinical Psychology Lecturer, combining NHS clinical work with research and education at the SGDP Centre.
Do you analyse #polygenic scores across ancestry groups? See Oliver Pain's extension to the GenoPred pipeline, with recommendations for good practice and efficient analysis. @oliverpain.bsky.social
🔗 Paper: lnkd.in/evJ9daBF
🔗 GenoPred pipeline: lnkd.in/eKwFr9kQ
www.linkedin.com/posts/oliver...
We're back, with a fresh new lineup of talks and workshops!
Get your place while you still can to learn about how to make your research more robust and how to deal with scientific fraud!
This event is free and open to all: tinyurl.com/3ewaduvm
🎉(1/4) Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @estbiobank.bsky.social , leveraging data from questionnaires and clinical notes using NLP.
www.nature.com/articles/s41...
Sunflowers in my garden - pretty, but no relevance to the message.
This morning's email had *four* paper review requests - again.
Important to contribute to keeping peer review moving. We have two papers languishing at journals for 6-9 months, with real impact on #ECR careers.
Suggestions for short-term fixes to help this broken system?
#academia #publishing
Presenter giving project updates
At @edinburghup.bsky.social University for two day AMBER team meeting.
@wellcometrust.bsky.social project to identify the causal mechanisms underlying #antidepressants using informatics, genomics & cellular approaches.
(1/2) Only one-third of people taking antidepressants for depression respond to the first drug they are prescribed and we know little about WHICH drug will work for each patient.
Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM
We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...
"This work is a first step in using health records to define and predict SSRI drug responses." - Professor Cathryn Lewis @cathrynlewis.bsky.social is Deputy Lead of our Trials, Genomics and Prediction theme, and the research was supported by @nihr.bsky.social and @wellcometrust.bsky.social 👇
Our new paper assessing switching between antidepressants as a measure of non-response is now out in BPGOS.
Genetic studies show prediction from polygenic scores of remission from clinical studies.
Paper: www.sciencedirect.com/science/arti...
@kingsioppn.bsky.social Webstory ⬇️
Picture of five people in an academic office - stuent, two supervisors and two examiners. Broad smiles!
Congratulations to Lachlan Gilchrist for his successful #PhD viva on Friday. He even admitted to enjoying the discussion!
Thanks to examiners @daniellenewby.bsky.social and Golam Khandaker & my @drivehealth.bsky.social co-supervisor @ppetra.bsky.social.
@kingsioppn.bsky.social
Picture of a book case, overloaded with books, in an open space at the SGDP Centre at King's College London
The SGDP Centre Atrium bookshare captures so much of our work culture.
From The Very Hungry Caterpillar to Neuropsychiatry to Jane Austen & Sarah J Maas.
Books in English, Chinese, French.
Suggested donations supporting local charity.
All welcome to donate & borrow, @kingsioppn.bsky.social
Lecture theatre and slide
#IoPPNFestival Fran Denk @denklab.bsky.social, winner of @kingsioppn.bsky.social Dean’s award for Research Integrity highlighting the importance of statistical understanding and application to support good research practices - honest, rigorous, open, respectful.
#statistics rocks!
The #IoPPNResearchFest is here! Join us for rapid-fire talks by IoPPN staff on the latest research in psychiatry, psychology + neuroscience, from the power of belief, neurotrauma and more.
Follow us and @thementalelf.bsky.social for highlights and key messages.
#AcademiaSky
View of garden - formal beds, borders and backdrop of trees.
Similar vibe, less exercise - coffee in Darwin’s garden at Down House. Beautiful! And every plant was a monitored experiment @englishheritage.bsky.social
Mosaic!!! That’s a blast from the past, and a great browser name that captures what web research does so well - enables you turn single pieces of information into a coherent whole
#BNA2025 Great addition to a conference- a Reading Room - with a view. Thanks to The Queen’s Reading Room for funding and interesting sessions on reading + neuroscience
#BNA2025 Ekta Patel from the Psychiatry Consortium, part of @md-catapult.bsky.social launches our Academia - Industry symposium. Strengthening collaborations through grand challenges, target validation and engagement
Congratulations on both achievements!👶📰
Really clear interview - thank you for the translation.
Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social
(1/1) 🧠🌎 Just published in Nature Genetics:
“Psychiatric genetics in the diverse landscape of Latin American populations”
A comprehensive review of progress, challenges, and future directions.
🔗 www.nature.com/articles/s41...
#PsychiatricGenetics #GlobalGenomics
Oh no! Hope it all works out 🚞
Tomorrow? Agggh! Join us on the train
Picture of Cathryn Lewis' research group at the SGDP Centre, waving and smiling.
📬New job 📬 Postdoc role on the AMBER project, to undertake genetic analyses of antidepressant response. Join us! Important science, rich data, nice people. Please repost. @kingsioppn.bsky.social
#depression #statistics #genetics #pharmacogenetics #antidepressants
my.corehr.com/pls/coreport...
Join us for the ISPG Members' Meetup on March 26th!
Dr. Oliver Pain will present his groundbreaking research on polygenic scores and the innovative GenoPred pipeline.
Don't miss out: us06web.zoom.us/meeting/regi...
#ISPG #Genetics #PolygenicScores #Bioinformatics
Antidepressants are widely prescribed
- Potential for more personalised prescribing
- Building on clinical and patient perspectives for more effective treatment.
- Stronger research base needed
Paper covered in @theipaper.com inews.co.uk/news/health/...
8/end
Pretty flowers - decorative
Self-reported antidepressant outcomes capture more positive experiences than clinical remission.
Shaped by sociodemographic, clinical, and genetic factors. Patient perspectives are KEY.
Patient-centred data + clinical measures = greater understanding of treatment outcomes.
7/n
