Sagun

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease | Nature Neuroscience Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer’s disease (AD). In this study, we investigated the association between microglial activation and amyloid-β (Aβ) with reactive astrogliosis in individuals across the AD spectrum. We examined 101 individuals using positron emission tomography radiotracers to assess Aβ deposition ([18F]AZD4694), tau aggregation ([18F]MK-6240) and microglial activation ([11C]PBR28), along with plasma biomarkers for astrocyte reactivity (GFAP) and tau phosphorylation (p-tau217). We further evaluated 251 individuals with cerebrospinal fluid levels of the microglial marker sTREM2. We found that Aβ pathology was associated with astrocyte reactivity across cortical brain regions only in the presence of microglial activation. The microglia-dependent effects of Aβ on astrocyte reactivity were further related to cognitive impairment through tau phosphorylation and aggregation. Our r

101 individuals with AD were studied using PET radiotracers: [18F]AZD4694 for Aβ and [18F]MK-6240 for tau. Microglia impact astrocyte reactivity. PMID:41198899, Nat Neurosci 2025, @NatureNeuro https://doi.org/10.1038/s41593-025-02103-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...

AMAZING PAPER ALERT!
www.nature.com/articles/s41...

congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team.
This one is important and opens up lots of opportunityes.

Anti-Aβ immunotherapy-mediated amyloid clearance attenuates microglial activation without inducing exhaustion at residual plaques

Causal machine learning for single-cell genomics - Nature Genetics This Perspective explores causal machine learning in single-cell genomics, addressing challenges such as generalization, interpretability and cell dynamics, while highlighting advances and the potenti...

Very nice perspective on causal machine learning, perturbations + single cell omics, gene regulatory networks. nature.com/articles/s41... graph-based representations are important for getting to mechanism. This really resonates with me.

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪

Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻

🧵

@cp-immunity.bsky.social

www.cell.com/immunity/ful...

The predictive nature of spontaneous brain activity across scales and species Dimakou et al.’s review examines how spontaneous brain activity across species from C. elegans to humans encodes behaviorally relevant sensory, motor, metabolic, and interoceptive states. They hypothe...

The predictive nature of spontaneous brain activity across scales and species: Neuron www.cell.com/neuron/fullt...

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration Vicario et al. detected microglial mosaicism in histiocytosis patients, predominantly in the rhombencephalon gray nuclei and associated with astrocytosis, neuronal loss, and neurological symptoms in p...

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration: Neuron www.cell.com/neuron/fullt...

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration
www.nature.com/articles/s41...

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

www.nature.com/articles/s41...

Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.

Learn more: brainprize.org/winners/canc...

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature.
We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social
www.nature.com/articles/s41...

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠

www.nature.com/articles/s41...

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...

Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social

(Re)building the nervous system: A review of neuron–glia interactions from development to disease Neuron–glia interactions play a vital role in brain development, influencing processes like neuronal differentiation, synapse development, and myelination. In the mature brain, glial cells maintain h...

(Re)building the nervous system: A review of neuron–glia interactions from development to disease

Matthew D. Demmings et al. 🧪

onlinelibrary.wiley.com/doi/10.1111/...

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors - Nature Neuroscience This study shows that cerebellar Bergmann glia process noxious stimuli by integrating signals from the locus coeruleus. This mechanism modulates pain-related behaviors. These findings provide insight ...

Cerebellar Bergmann #glia integrate noxious information via noradrenaline signaling and modulate pain-related behaviors 🧪🧠

www.nature.com/articles/s41...

Prenatal stress effects on the placenta.

Maternal stress is a critical factor in the long-term health of offspring. A recent study (below) profiled the effects of prenatal stress on DNA methylation + gene expression in rat placenta & fetal brain.
🧪🧠🐀 #neuroskyence
www.nature.com/articles/s41...

snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patie...

www.cell.com/neuron/fullt...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...