Alice Laigle

What is biodiversity? What is genomics? How do they work together to support species monitoring & conservation? 🌍🧬

The #Connections series explores these questions: biodiversitygenomics.eu/category/con...

@unbiodiversity.bsky.social @biogeneurope.bsky.social @iboleurope.bsky.social

Parution de « La biodiversité en infographies » par Tatiana Giraud Pour la première fois, la biodiversité traitée sous l'angle de l'infographie. Par Tatiana Giraud, biologiste de l'évolution, directrice de recherche au CNRS au Laboratoire Ecologie Société Evolution - ESE (CNRS/UPSaclay/AgroParisTech, Gif-sur-Yvette) et membre de l'Académie des Sciences.   Préface de Valérie Masson-Delmotte.   A travers 200 schémas simples et précis, La biodiversité en infographie met à la portée de tous l'état des connaissances scientifiques actuelles sur la biodiversité.   La biodiversité n'est pas simplement un catalogue des êtres vivants sur terre, une liste de grands mammifères, d'oiseaux ou de papillons, identifiés et comptabilisés. Parmi les 2,15 millions d'espèces connues, les plantes et les animaux ne représentent que la partie visible d'un extraordinaire ensemble, en grande majorité composé de micro-organismes imperceptibles à l'oeil nu, mais dont le rôle est vital. Véritable équilibre dynamique, la biodiversité se maintient en évoluant sans cesse, grâce à des interactions multiples et complexes dont nous dépendons pour notre santé et même pour notre survie.   Aujourd'hui, 28 % de ces espèces sont menacées d'extinction. Les populations s'effondrent, les habitats naturels disparaissent, les pesticides empoisonnent l'environnement. L'équilibre est perturbé, et sa capacité d'adaptation est de plus en plus compromise. Il est possible d'enrayer cette spirale ! Chacun peut agir, individuellement et collectivement. Mais avant de se lancer, il faut d'abord comprendre en profondeur ce qu'est la biodiversité, appréhender les interdépendances entre les espèces, puis décrypter les causes à l'origine de cet effondrement. Sans cette compréhension, les décisions prises peuvent aggraver le problème – alors que les vraies bonnes solutions sont à notre portée : sortir de l'agriculture intensive, lutter contre la destruction des milieux naturels, contribuer à des programmes de science participative...   Avec plus de 200 infographies synthétiques, claires et précises, La biodiversité en infographies permet de visualiser en un clin d'oeil les enjeux liés aux écosystèmes. Un foisonnement de connaissances scientifiques, qui offre de nombreuses clés pour devenir acteur de la préservation du tissu vivant de la planète.   -> Contact : tatiana.giraud@universite-paris-saclay.fr

Parution de « La biodiversité en infographies » par Tatiana Giraud

The biodiversity, genomics, ecology and evolution of mushroom-forming fungi - Nature Reviews Biodiversity Mushroom-forming fungi have along evolutionary history and a suite of important ecological roles. This Review highlights advances in understanding of Agaricomycetes evolution and ecology driven by gen...

Everything you always wanted to know about mushroom-forming fungi! Great collab with amazing mycologists. Thanks Laszlo Nagy for leading this effort!

www.nature.com/articles/s44...

NEBULAE : Origins of Stars - résumé d'une manche YouTube video by GalactiCamille

Bluesky fais ta magie!
Je suis à la recherche de partenaires pour contribuer à financer mon #JeuDeSociété à portée pédagogique sur la formation des étoiles #Astrophysique #Vulgarisation #SciComm !
L'autre partie du financement se fera sur Ulule!

www.youtube.com/watch?v=WE5R...

Merci🪐 🌟 🌌 🌕 🔭 🚀 🛰️

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?

Yes, one can. with CUT&ID ✂️🪪

Spearheaded — singlehandedly — by @annanordin.bsky.social

No need of transgenesis, cloning and overexpression.

Check it out, it's fast and its works.

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...

a computer generated image of a dna structure ALT: a computer generated image of a dna structure

Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

Please share🙏:

Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona

Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi
www.upf.edu/documents/d/...

Computational in Physical Chemistry of cellular processes under extrem environments
www.upf.edu/documents/d/...

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

Poster for upcoming webinar. Title: Fungal Conservation in the New Year: Species Discovery, Action, Policy, and a Global Strategy. Seven February 2026 11AM PST / 2PM EST / 4PM BRT / 7PM GMT with a registration link. Photos of presenters with talk titles. Huzefa Raja: Discovery is the first step toward conservation: Atromagnispora, a newly identified genus of freshwater ascomycete fungus from Indiana. Kelmer Martins-Cunha: From fungal neglect to action: shifting paradigms in Brazilian conservation. Greg Mueller: Developing A global strategy for fungal conservation. Images of 4 fungi are followed by the text "A webinar presented for Reverse the Red Day" and the logos of Reverse the Red, IIUCN SSC Mushrooms, Brackets, and Puffballs Specialist Group. Global Center for Species Survival at the Indianapolis Zoo. IUCN SSC FUNCC. IUCN SSC Brazil Fungal Specialist Group.

I just saw this and am excited to share!

🍄 Reverse the Red Day 7 Feb.
"Fungal Conservation in the New Year: Species Discovery, Action, Policy, and a Global Strategy"

us02web.zoom.us/webinar/regi...

Calling all OrthoFinder users!

We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny.

GLADE runs directly on OrthoFinder results.
www.biorxiv.org/content/10.6...
github.com/lauriebelch/...

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Thank you to my co-authors: @camillecornet.bsky.social, @crazychipkali.bsky.social, @tobybarilbio.bsky.social io.bsky.social and @danielcroll.bsky.social. And thank you to @oggenfussursula.bsky.social for her advice

Hi everyone!
The talk I had the chance to give with @fnucleosome.bsky.social last October is now out on Youtube!
If you like evolution, 3D genomics, biodiversity and/or fungi, I think you might like it! 🧬🧪🍄
The submission of this paper has never been that close!

www.youtube.com/watch?v=Plez...

It’s now official! INRAE is recruiting: @inrae-bioger.bsky.social is offering a permanent position as a research scientist to identify #plant #susceptibility factors to #fungal diseases. Visit jobs.inrae.fr/en/open-comp... before March 5, 2026 to apply!

Summer School on Chromatin Biology 2026 Hands-on Expedition at Helmholtz Munich

The Epigenetics Community at #HelmholtzMunich, together with #Abcam, is hosting the 3rd #Chromatin #SummerSchool in Munich:

📆 17–29 August 2026
⏰ Apply by March 29, 2026

👉 Applications & info: bit.ly/4oGDR8f

@epihmgu.bsky.social @metorrespadilla.bsky.social @robertife.bsky.social

I am looking for a PhD student to join my new Socio-Eco-Evo group, hosted in Katie Peichel's Evolutionary Ecology Division @ University of Bern. We're offering a fully funded 4-year position, studying social plasticity and behavioral adaptation among stickleback in Greenland. Please share around!

Doctoral Researcher (m/f/div) in Microbial Genetic Engineering - Leibniz-HKI

📣 Job opportunity: I’m still looking for an enthusiastic PhD student to join my lab @leibniz-hki.de who is interested in fungal natural product research and genetic engineering. We’ll work on an interdisciplinary project with the team of @luziagyr.bsky.social 👇🏻

www.leibniz-hki.de/en/job-offer...

Genomic and physiological signatures of adaptation in pathogenic fungi - Nature Communications Emerging fungal pathogens have detrimental impacts on crops, animals, and humans, however little is known about their transition to a pathogenic lifestyle. This study demonstrates that the transition ...

What enables a fungus to invade a mammal host? @marco-guerreiro.bsky.social unravels signatures of translation adaptation among pathogenic and non-pathogenic species of Trichosporonales. See more: www.nature.com/articles/s41...

Germline fate determination by a single ARGONAUTE protein in Ectocarpus | PNAS ARGONAUTE (AGO) proteins are a highly conserved family of RNA-binding proteins that play central roles in gene regulation and developmental process...

One protein. One pathway. A whole germline fate.

New paper from my postdoc @mpi-bio-fml.bsky.social out in PNAS:
Germline fate determination by a single ARGONAUTE protein in Ectocarpus www.pnas.org/doi/10.1073/...

📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.

Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇

Big news! At least for me. I'll start building my own research group at the amazing IMBA in Vienna. Starting from single-cell omics data, we will develop computational tools and theoretical models to understand how single cells make decisions, in particular during development. I think that IMBA is

1/🧵
Major milestone unlocked for mycology! 🍄

We just published a massive genomic resource in 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐃𝐚𝐭𝐚, releasing 2,695 complete circular mitochondrial species assembled from public data

This single dataset nearly 𝐓𝐑𝐈𝐏𝐋𝐄𝐒 📈the known mitochondrial diversity of the Kingdom Fungi
rdcu.be/eYZ2h

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

👏 Congratulations Toby for this Current Biology dispatch!
🎨 Happy to see my watercolours in it to illustrate this so-cool topic!

#illustration #sciart #scicomm #TE #fungi #watercolours #TEworldwide

Friendly smiling kiwi with blue shoes and a waving strawberry with yellow shoes

Continuing a side project, mostly made for children 🍓

#scicomm #sciart #digital #children

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...

What happens when you suddenly remove half of an essential enzyme from cells? 🤔

We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.

Our lab's new preprint 👇

bit.ly/4pyPgax

Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen Abstract. In many fungal phytopathogens, infection is regulated by accessory genomic regions enriched in facultative heterochromatin, but the precise role

Beyond excited to see this work finally out in @narjournal.bsky.social! We show that epigenetic modifiers on fungal accessory chromosomes can contribute to the overall epigenetic profile. Many thanks to @gomezlucia93.bsky.social and our other amazing collaborators 👏🏻

academic.oup.com/nar/article/...

Fresh news on de novo genes! Happy to present our latest work published in Nature communications: www.nature.com/articles/s41...

Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)

Three-dimensional genome architecture connects chromatin structure and function in a major wheat pathogen - BMC Biology Background Genome spatial organization plays a fundamental role in biological function across all domains of life. While the principles of nuclear architecture have been well-characterized in animals ...

Our paper on Zymoseptoria tritici 3D genome organization is officially out! @iglavincheska.bsky.social
link.springer.com/article/10.1...