@bilderlab

I've had a bit of a hiatus due to faculty job apps, but the Etsy shop is open again and ready for your holiday orders! All proceeds go to @flybase.bsky.social , and I just sent the August/September revenue donation. So grab some #drosophila stocking stuffers =>

@bilderlab.bsky.social Karaoke night. Please clap for my charcuterie board.

Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."¹ Some of these responses le...

FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting - PubMed Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use ...

Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.

😀 en.wikipedia.org/wiki/Shoshin

Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."¹ Some of these responses le...

FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/

None necessary! Hoping future flaming elmos come our way.

Why do patients with cancer die? - PubMed Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease...

Much better-informed folks actually wrote a review on this last year: pubmed.ncbi.nlm.nih.gov/38898221/

We got into this because I guess I have the mind of a 7 year old and didn't understand 'how does cancer kill' -- thought flies could give insight. some info in this from @natrevcancer.nature.com pubmed.ncbi.nlm.nih.gov/34389815/

Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting - PubMed Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use ...

Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.

And so fabulous to dine out with former postdocs Anne Classen @classenlab.bsky.social, Thomas Vaccari @vaccarilab.bsky.social and Lucy O’Brien. Many laughs, fond memories, and talk of bright futures for all of them. #EDRC2025

Honored to share stage with all the great plenary speakers at #EDRC2025. Exciting science and great vibes from Drosophila researchers worldwide – Let’s keep the American, Euro, and APAC communities coordinated and strong!

Basement membrane perforations guide anterior–posterior axis formation - Nature Communications Chen et al. show that in mice, extracellular matrix remodeling drives early migration of the anterior signaling center, establishing the body axis sooner than expected—a mechanism potentially conserve...

Beautiful paper from former student @dy-chen.bsky.social now postdoc in Zernicka-Goetz lab. Human embryos, stem cell models & mice: BM heterogeneity drives AP symmetry breaking. High-end microscopy, live imaging, physical modeling, mechanistic tests. Tour de force. www.nature.com/articles/s41...

Amazing and multitalented postdoc @ongkaty.bsky.social taking time out from writing her new paper with this generous initiative. #genetics, #CRISPR, #drosophila, hallmarks of #cancer and more. For a great cause; support @flybase.bsky.social!

gold crispr-cas9 enamel pins

drosophila embroidered patches and enamel pins

IgM antibody enamel pins in purple and cyan

All proceeds from my #sciart Etsy shop will now be donated to
@flybase.bsky.social . Due to fed cuts, this beloved resource that I use daily has lost it's funding, and I'm helping in my small way. Now's a good time stock up on #STEM & #drosophila gifts & swag!
www.etsy.com/shop/Picosti...

Advancing cancer research via comparative oncology Nature Reviews Cancer - Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular...

Happy to share a new publication: an introduction to comparative oncology in @natrevcancer.nature.com‬. Thanks to the leaders in the field for welcoming me as an invertebrate researcher.
rdcu.be/etKdN

New paper from superb postdoc Hui-Yu Ku about how proteases pattern extracellular matrix to precisely sculpt an organ.
She will soon be an independent PI at National Yang-Ming University in Taiwan, expanding to study how ECM regulates egg activation. Congratulations! www.pnas.org/doi/10.1073/...

Thursday, May 22 from 1 – 2:15 pm ET, Wu-Min Deng,
@perrimonlab.bsky.social and I will discuss fly cancer models during a #BeyondMammals webinar held by the NCI. Register for free to hear some of the many ways that Drosophila can contribute to #CancerResearch. events.cancer.gov/dcb/beyond-m....

Congrats to MCB's Diana Bautista and David Bilder for being named as AAAS Fellows @aaas.org! @bilderlab.bsky.social 👏 🎉https://news.berkeley.edu/2025/03/27/seven-faculty-members-named-fellows-of-american-association-for-the-advancement-of-science/

A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation Drosophila tumor suppressor genes have revealed molecular pathways that control tissue growth, but mechanisms that regulate mitogenic signaling are fa…

We have also donated our anti-Grnd (one of two #Drosophila TNF Receptors) monoclonal —coming soon (5/5)
www.sciencedirect.com/science/arti...

Anti-Hemese staining of plasmatocytes —essentially #Drosophila macrophages. Dm 1.2/1. Image by Yoshiki Sakai in the lab. (4/5)

Anti-NimC1 staining of plasmatocytes —essentially #Drosophila macrophages. Combination of Dm N1/9 and Dm N47/7. Image by Yoshiki Sakai in the lab. (3/5)

These donations continue the spirit of the “Fly worker ethos” —others are encouraged to do the same! (2/5)
pubmed.ncbi.nlm.nih.gov/28684603/

#Drosophila community: Dr. Istvan Ando has generously donated his invaluable anti-hemocyte monoclonal Abs to the #NIH-founded public repository @dshb-antibodies.bsky.social in #Iowa. We’ve tested several of them and they look great. See the🧵 for details.
(1/5)

Citrus tasting at the annual @bilderlab.bsky.social Lunar New Year Party 🍊

Thursday, January 30 from 1 – 2:15 pm ET, Wu-Min Deng, @perrimonlab.bsky.social and I will discuss fly cancer models during a #BeyondMammals webinar held by the NCI. Join to hear some of the many ways that Drosophila can contribute to #CancerResearch. events.cancer.gov/dcb/beyond-m....

Part of our lab studies #Drosophila cancer models. Delighted to announce ‘Beyond Mammals: Exploring Cancer Models” webinar held by NCI, hopefully in advance of funding opportunities. I’m speaking with @perrimonlab.bsky.social and others incl #Zebrafish and #Celegans PIs. Registration free.

Hosted a joint lab retreat with @LOBrienLab.  Shared lots of science, some lore, and a bit of history, and introduced the Stanford folks to some of the joys of Berkeley.

New lab preprint —longtime project finished in Hong Kong by new investigator @Jung_Kim_PhD.

www.biorxiv.org/content/10.1...

Now accepting applications- come join us in Berkeley!
#Drosophila #Celegans
careerspub.universityofcalifornia.edu/psp/ucb/EMPL...