Very interesting work!
04.02.2026 21:57
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Very interesting work!
I’m very pleased to share our work looking at what controls condensin II cell-cycle dependant activity; a great collaboration with @eugenekimlab.bsky.social, @damlatetiker.bsky.social, Kyle Muir and Kumiko Samejima
www.biorxiv.org/content/10.6...
Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology!
🌎 Location: Les Diablerets, Switzerland
📆 Save the date: June 27-28, 2026
🔗 More information: www.grc.org/single-molec...
#biology #biophysics #single-molecule #microscopy #ECR
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Super excited to share that our paper is now out in @science.org. Lots of work, but also lots of fun getting this out.
Be sure to check it out!
www.science.org/doi/10.1126/...
Also, follow:
@huabin-zhou.bsky.social @juliamaristany.bsky.social @kieran-russell.bsky.social @rcollepardo.bsky.social
Glad to see this out after a rather interesting review/publication process!
www.nature.com/articles/s41...
We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you.
Application deadline: 24 December
www.crick.ac.uk/careers-stud...
Super cute! Congratulations, Erin! ☺️
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
A diverse team of Crick researchers has come together to make some surprising new insights into how copies of DNA are held together by the ring-shaped protein complex cohesin during the replication process.
www.crick.ac.uk/news/2025-09...
Our Wadjet-II paper by @roisnehamelinf.bsky.social is out in polished form: www.cell.com/structure/fu...
With a great preview by @kevincorbett.bsky.social & @amardeeep.bsky.social highlighting the potential of Wadjets:
Wadjet—Keeping a watchful eye on circular DNA.
www.cell.com/structure/fu...
Our paper is now out in Molecular Cell!
Check the thread in this former post:
www.cell.com/molecular-ce...
I'm very pleased to share this work, which discovers a new material property of DNA—the bending friction— in essence how "sticky or viscous" DNA is as it bends & loops due to all the complex molecular interactions within itself & water
@imperialcollegeldn.bsky.social
@crick.ac.uk
@ucl.ac.uk
⚛️🧪
A new material constant of DNA is the major determinant of looping dynamics https://www.biorxiv.org/content/10.1101/2025.07.10.664086v1
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Very pleased to share our new story on SMC complexes, a great team effort from @roisnehamelinf.bsky.social, @taschner.bsky.social in the GruberLab and James of @dnatopologylab.bsky.social We find that SMC hinge domains are ssDNA gates to facilitate obstacle bypass during DNA loop extrusion!
Side view of the structure of a monomer of type II Wadjet.
Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.
A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March:
www.crick.ac.uk/careers-stud...
For anyone that was too busy at the end of last year to think about PhDs or are still looking for the right project/place, I have a project available in the second round of the Yorkshire Biosciences DTP scheme looking at the dynamics of human condensin:
www.findaphd.com/phds/project...
Congratulations to @mmlab.bsky.social and team, who using the C-Trap, were able to grow microtubules from beads in solution and show that HSET (kinesin-14 family) with microtubule tip-tracking protein can harness forces generated by growing microtubule tips: www.nature.com/articles/s41...
Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/...
Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social
Exciting news 📃🧬🔬
Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Come and do your PhD with us @TheCrick and @UCL_IPLS starting October 2025. Apply here: www.ucl.ac.uk/epsrc-doctor...
We measured forces generated in bipolar spindles replacing spindle poles with optical traps!
Read more here: www.nature.com/articles/s41...
Please share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes!
Contact me at e.cutts@sheffield.ac.uk
For details on how to apply: www.findaphd.com/phds/project...
👀SMC 🛵 on 🧬 induce 🥨 at each➰
www.science.org/doi/10.1126/...
by @ceesdekker.bsky.social @romanbarth.bsky.social et al.
