Hellen C. Greenblatt

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from.....

#Rheumatoid arthritis -induced #dysbiosis of the #periodontal #microbiome→ periodontal inflammation → periodontitis-driven exacerbation of systemic #inflammation. bit.ly/4chLQWT [Open Access]

Eating More Ultra-Processed Foods Raises Heart Disease Risk by Nearly 50% Eating more ultra-processed foods may raise heart attack and stroke risk by nearly 50%.

High consumption of #ultra-processed foods → ↑ #hs-CRP [#inflammation]. bit.ly/3OvVFGP and 47% ↑ of #CVD and may contribute to ↑ risk of gastrointestinal diseases. bit.ly/4kPVWjN bit.ly/3OtW2Se

When attacked by the same virus, individuals produce #antibodies that target different parts of that virus. For a given #virus, some antibodies increase with #age while others decrease, depending on the viral fragment targeted. bit.ly/40kYPzG bit.ly/4rlralr [open access]

In older individuals, ↑ #inflammation and lower levels of #antioxidant assoc. w poorer #sleep. [open access] bit.ly/4cvAxKA bit.ly/4aI3kJI

Respiratory virus immune response in the aged host - Immunity & Ageing Immunity & Ageing - Viruses are a major cause of acute respiratory illness in older adults and pose a substantial burden as the elderly population continues to grow. In the current COVID-19...

#Aged host: Respiratory virus immune response [a review]. Aged mice ↑ expression of #inflammatory genes. Distinct changes in the inflammatory profile and gene expression signature of monocytes and macrophages in the aged host, particularly in the #lung microenvironment. bit.ly/4rQ65zz

Repurposing “Bad Cholesterol” to Precisely Target Inflammation in Atherosclerosis Professor Lisa Volpatti developed a targeted approach that directs anti-inflammatory proteins to diseased arteries, reducing immune cell activity and improving therapeutic effectiveness.

Targeted delivery that directs #IL-10 to #atherosclerotic #plaques with precision, modulates #inflammatory pathways. bit.ly/3ZgeUq5 go.nature.com/3OoyNsy

Key Role of Pro230 in the Hinge Region on the Architecture and Function of IgG1 Immunoglobulin G (IgG) is a multifunctional glycoprotein essential for immune defense and widely used as a therapeutic due to its antigen specificity and effector functions. However, the inherent flex...

Deleting a single amino acid in #IgG lower hinge alter sits assembly and immune signaling, e.g. impair interactions with #Fcγ receptors. bit.ly/4rsdrJo [open access]

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Cytosolic nucleic acid sensors contribute to pathogenic and autoinflammatory inflammation; however, little is known about the metabolic adaptations that they induce. Dunphy et al. find that these path...

Virus →#IFN-1→ ISG15. ↆ #mitochondrial membrane potential → ↑ mitochondrial fragmentation. ↆ inflammatory gene expression→ ↆ #inflammation and ↑ clearance of tissue damage. bit.ly/4qNGCq3 [open access].

#Exercise ↑ FOXO [#longevity’ genes and #anti-inflammatory] →ↆ #DEAF1. ↆ DEAF1 → muscle cells regain their ability to recycle damaged parts and stay healthy. Exercise helps restore homeostasis within muscle cells and keeps muscles stronger for longer. bit.ly/49PVRaU

Inflammatory Factors and Chronic Rhinosinusitis: An Umbrella Review Chronic rhinosinusitis (CRS) is a common inflammatory disorder of the nasal mucosa and paranasal sinuses characterized by persistent sinonasal symptoms and objective endoscopic and imaging evidence of...

Three immune-inflammatory patterns differ: in sequence of the inflammatory mediators, the immune cell populations involved, and the associated physiologic functions in #rhinosinusitis. bit.ly/4b3Igiv [open access].

Inflammation PET and plasma neurofilament light predict survival in people with progressive supranuclear palsy Shapiro et al. report that inflammation PET signals in subcortical regions and plasma neurofilament light levels are complementary prognostic biomarkers in

Progressive supranuclear palsy (#PSP) → atrophy and #inflammation of the brainstem, the basal #ganglia and, to a lesser degree, the #cortex. ↑ subcortical neuroinflammation→ assoc. with shorter survivals. bit.ly/4qj4hyr [open access]

The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis Gut bacteria are important in causing inflammatory bowel diseases. By combining the results from published studies we have identified the key changes in these bacteria that might help us develop new d...

ↆ anaerobes and ↑ of oxygen-tolerant, orally associated #gut #microbiome signatures in treatment-naïve new-onset #IBD. Migration of bacteria from the mouth to the gut may play a key role in triggering #inflammation. bit.ly/49tcRU1 bit.ly/4puJkPW

Progressive #MS →hallmark of grey matter injury = compartmentalized #inflammation (CI) of the #leptomeninges. In vivo, 800x ↑ #CXCL13 + significantly ↆ BAFF assoc. w CI . Ratios → grey matter injury.bit.ly/4q0kxUZ go.nature.com/3Yk0AfL

Neurobehavioural links from infant screen time to anxiety Higher infant screen time is linked to accelerated topological maturation of the visual and cognitive control networks, leading to prolonged decision latency and increased adolescent anxiety. Sensory ...

#Infancy particularly sensitive period for #screen exposure. Exposure <2 yrs → ↑#brain maturation, ↆ decision-making, and ↑ anxiety by #adolescence. Shared reading 3yrs ↆ the brain- alterations suggesting a protective effect. bit.ly/3MZXdZ2 [open access]

P1223 Maternal dietary patterns during pregnancy and offspring’s risk of paediatric Inflammatory Bowel Disease - a cohort study AbstractBackground. The association between maternal dietary patterns during pregnancy and offspring’s risk of paediatric-onset inflammatory bowel disease

Diverse diet during #pregnancy= ↑ meat, fish, vegetables, legumes, fruits, potatoes→ ↆ risk of #IBD vs Western-style diet. bit.ly/4aCM2z5 go.nature.com/49cY8fP

Inflammation in areas of fibrosis precedes loss of kidney function in lupus nephritis Background Interstitial fibrosis in lupus nephritis (LN) is often infiltrated by immune cells but typically regarded as non-specific ‘scar reaction’. This study aimed to investigate the relationship b...

#Inflammation in areas of #fibrosis precedes loss of kidney function in #lupus nephritis bit.ly/4pFLT2q [open access]

Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...

Long #COVID (n=142)→ persistent activation of chronic #inflammation. Including proinflammatory #cytokine signaling, #complement activation, #metabolic dysregulation and immune #exhaustion. Suggestion of link between metabolic dysregulation and inflammation. go.nature.com/48UfU7B
[open access].

The neural basis of endogenous reinforcement learning.

Vividly imagining a positive interaction with someone can increase how much you like them — and alter how your brain stores information about that person. (Similar to those seen when people learn from real rewarding experiences.) bit.ly/4ac9dAe go.nature.com/48SDuS9 [open access]

Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study | Circulation: Cardiovascular Imaging BACKGROUND: Psychosocial stress is linked to the development of cardiovascular disease, with a more pronounced impact in female participants. This study investigates sex differences in the association...

#Women w psychosocial stress, e.g., #caregiving and lack of emotional support→ early heart tissue changes assoc. w #CVD. MRI scans →signs of #inflammation. Not observed in males. bit.ly/4pQUzCJ bit.ly/4iKH9Wz

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin

#Adipocytes → #obesity-associated chronic #inflammation and metabolic disorders via two @#β2-microglobulin-dependent mechanisms. bit.ly/4poJMA9 [open access]

Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction - Immunity & Ageing Aging has profound effects on whole-body homeostasis. With age, adipose tissue undergoes marked alterations in immune microenvironment and distribution as well as a loss of immune and metabolic capaci...

#Age-related #inflammation disrupts #adipose tissue #homeostasis, interferes with its metabolic functions, → age-related diseases. bit.ly/4obug9a [open access

Resveratrol–Copper Combination Suppresses Glioblastoma Growth and Restores Immune Function A small but powerful clinical trial reveals that resveratrol and copper can reduce tumor growth, restore immune function, and clear harmful DNA fragments in glioblastoma—without adverse effects.

Oral administration of #resveratrol and #copper may have a profound effect on the aggressive phenotype of #glioblastoma. [5.6 mg of resveratrol and 560 ng of Cu 4x/day for an average of 11.6 days]. How about other neoplasms? bit.ly/49tSXtQ go.nature.com/4oPpuQ1 [open access]

Systematic profiling reveals betaine as an exercise mimetic for geroprotection Elucidating the multi-faceted health effects of exercise in humans identifies kidney-derived betaine as an exercise mimetic acting as a TBK1 inhibitor with anti-inflammatory and geroprotective activit...

#Exercise→#betaine→#inflammation, muscles, heart, genes, proteins shift over weeks, not minutes. ↑ betaine →ↆ inflammation, cellular #aging ↆ, ↑ energy expenditure, ↑ gut bacteria→ ↑ immune strength and antioxidant activity. bit.ly/446OZUp bit.ly/47LKoJL

Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature This multi-omic longitudinal analysis of the healthy&nbsp;human peripheral immune system constructs the Human Immune Health Atlas and&nbsp;assembles data on immune cell composition and state changes w...

Immune #ageing dynamic, non-linear process shaped by both intrinsic and extrinsic factors. Peripheral immune cell subsets change with age → immune responsiveness independently of overt systemic #inflammation or underlying chronic #CMV infection. go.nature.com/3JLQYXf [open access]

The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19 - Immunity & Ageing Background Amidst the ongoing COVID-19 pandemic, understanding factors that influence vaccine efficacy is crucial, particularly in older adults. Regular physical exercise and/or structured physical ac...

Moderate to high-intensity #exercise (50–70% of maximum heart rate for aerobic exercise and 60–80% of 1RM for resistance training), performed 3–5 times per week, ↑ immune responses to #COVID-19 vaccination, particularly by ↆ chronic low-grade #inflammation. bit.ly/4qGhAJT

Frontiers | Cytokines in sepsis: a critical review of the literature on systemic inflammation and multiple organ dysfunction Sepsis constitutes a profoundly heterogeneous and dynamic clinical syndrome, precipitated by a maladaptive host response to infection in which the immune sys...

#Cytokines in #sepsis, a review. Sepsis → maladaptive host response to infection. Interplay between proinflammatory and anti-inflammatory pathways pathologically skewed. Central role of cytokine storms in activating and regulating the systemic #inflammatory cascade. bit.ly/4qR2TUD

Immune-mediated interactions between sarcopenia and atherosclerosis in aging - Immunity & Ageing Sarcopenia and atherosclerosis are prevalent age-related conditions increasingly recognized as interconnected through shared immune-mediated pathways. This review elucidates how “inflammaging” driven ...

Circulating levels of IL-6 and TNF-α reflect systemic #inflammation and link muscle #wasting and #vascular degeneration. HsCRP, a validated cardiovascular risk marker downstream of IL-6, is correlated with #sarcopenia progression. bit.ly/47OelbY

SMOKING TRIGGERS DISTINCT INFLAMMATORY MECHANISMS IN HEALTHY INDIVIDUALS AND PRIMARY LUNG CANCER PATIENTS. The specific contribution of smoking to oxidative stress (OS) and systemic inflammation in lung cancer (LC) patients, as well as the potential synergi…

Smoking → oxidative damage and #inflammation→ lung #cancer development by generating reactive DNA species and fostering oncogenic processes. (Modest sample size.) bit.ly/3L8mYW5

Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells Mitochondrial and lysosomal signaling orchestrates Treg cell metabolic states and functional fitness.

A tale of two organelles: #Mitochondria and #lysosomes
Activated cell states → ↑ mitochondria vs. resting cell states. These mitochondria have more dense cristae, suggesting they are an important part of regulatory T cell activation during #inflammation. bit.ly/4qLclsH bit.ly/3LdvLWx

Frontiers | Editorial: The role of inflammation in organ injury Inflammation represents one of the most fundamental and evolutionarily conserved biological responses for host defense against pathogens and tissue injury (1...

Analysis of IL-17A in multisystem #inflammatory syndrome → insights into pediatric #inflammatory responses following SARS-CoV-2 exposure. IL-17A may be not only as mechanistic player but also a valuable prognostic marker. Editorial bit.ly/4qn6rxn