Hoifung Poon

Paper: aka.ms/gigatime-paper
Model: aka.ms/gigatime-model
Code: aka.ms/gigatime-code
Azure Foundry: labs.ai.azure.com/projects/gig...

The GigaTIME model is open-weight and publicly available. We're looking forward to feedback from the community and joining force towards precision immuno-oncology.

In joint work with Providence and University of Washington, we developed GigaTIME, a multimodal AI that can simulate spatial proteomics from routine digital pathology slides, thus enabling large-scale study of spatial medicine that was previously unthinkable.

Spatial proteomics offers a powerful modality to decode tumor immune microenvironment (TIME) grammar that governs immunotherapy response and the life and death of a patient. But such data is extremely time-consuming and expensive to produce.

Immunotherapy is the most promising direction for taming cancer once and for all, but the overall response rate is still far too low even for the best-in-class treatments such as Keytruda.

Scaling insights into immunotherapy with GigaTIME YouTube video by Microsoft

Excited to share a short and sweet video showcasing the science and people behind our GigaTIME paper, recently published in Cell: youtube.com/watch?v=fVZc.... Thanks Joseph Tartakoff and
@Microsoft CEO Office for driving the production.

What these nihilistic vandals are doing to dismantle science & medicine—generations of expertise & public service & life improving benefits—is cultural revolution level national self harm. No foreign foe could inflict such brutal damage & senseless suffering on US so fast & effectively & unresisted.

a poster that says if life gives you lemon make lemonade on it ALT: a poster that says if life gives you lemon make lemonade on it

ATTENTION (PLEASE SHARE)

If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.

There are lots of talented and accomplished people who may be looking for new opportunities.

The AP provides a model of effective press resistance Credibility is more important than access.

New in PN: The AP provides a model of effective press resistance

"The dispute over the name of the Gulf of Mexico seems trivial, especially compared to the others horrors Trump is currently perpetrating. But tyrants are tyrants in part bc they insist on asserting control over even trivial matters."

I wrote a book The Creative Destruction of Medicine (2013, title adopted after Schumpeter).

This title of the book for what we are now seeing in the U.S. is just The Destruction of Medicine.

I can't believe they've just cancelled the Epidemic Intelligence Service program at CDC.

This program trains the best & brightest epidemiologists, who then go on to have distinguished careers in public health, serving at CDC, in state health departments, overseas, ...

Imagine if @aoc @sanders.senate.gov , every dem, SIMULTANEOUSLY held Town Halls where they allowed grant and contract recipients to explain to the country what it is they do and why it's important

Invite all media. Including RW podcasters. @spaces Flood the zone

Call it a Day Of Transparency

This energy.

How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

This is the most relevant article to NIH and research cuts I’ve seen.

Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”

globalnews.ca/news/9793403...

Another example of what cutting science funding is doing to our leading university research programs in the U.S.: dismantling things like the Soybean Innovation Lab at UIUC, which have made US crop yields dramatically higher.

I’ve been seething and grieving since yesterday’s Friday Night Massacre of NIH overheads, a seeming bit of bureaucratic trivial that will in fact destroy the US university system if unchecked. But I want to get away from budgets and rate breakdowns and F&A percentages for a moment.

Humor me?

We should not be allowing non-government employees to waltz in to government offices, and illegally get access to sensitive government and personal data, and get read and write access to critical software systems in multiple government agencies.

www.npr.org/2025/02/08/g...

Absurd time…

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

If hostile foreign nations made a plan to destroy US influence and power, it would probably involve shutting down NIH and NSF

To help people understand the importance of NIH, share what you’ve used their funding for (in easily understandable terms).

I’ll start: my NIH postdoc funding helped me develop and test AI tools that could identify skin cancer across diverse skin tones.

This week's cover and editorial @thelancet.bsky.social on mis- and disinformation's impact on public health
www.thelancet.com/journals/lan...

With the confluence of digitization and intelligence revolution, we now have an unprecedented opportunity to unlock population-scale real-world evidence for advancing precision health and democratize high-quality healthcare for EVERYONE. So much remains to be done!

We also want to highlight the Best Papers for the other years dl.acm.org/journal/heal.... Big Congrats!

We are honored and humbled by this great recognition and want to express our sincere appreciation to ACM Health Editor-in-Chief Gang Zhou and the Best Paper Award Committee Co-Chairs Devika Subramanian and Jiayu Zhou for their service to the computational health community.

In 2024, ACM Health started an annual Best Paper Award to recognize the paper with "the most significant contributions and impacts in the field of computing for healthcare", including retrospectively for years 2020-2023.

Given the digital transformation in biomedicine and the emerging prevalence of computational applications, the Association for Computing Machinery (ACM) established ACM Transactions on Computing for Healthcare (ACM Health) as the flagship ACM journal for computational health research.

Kudo to co-first authors Yu Gu, Robert Tinn, Hao Cheng for driving the project to a big success, and big congrats to all the co-authors Michael R. Lucas, Naoto Usuyama, Xiaodong Liu, Tristan Naumann, Jianfeng Gao.

PubMedBERT (a.k.a. BiomedBERT) has since become a key building block of our own subsequent explorations, such as BiomedCLIP ai.nejm.org/stoken/defau..., BiomedJourney arxiv.org/abs/2310.10765, BiomedParse www.nature.com/articles/s41....

With amazing collaborators, we're among the first to explore LLM and multimodal GenAI in precision health. PubMedBERT has been cited for 2,000+ times arxiv.org/abs/2007.15779, with over 10MM downloads huggingface.co/microsoft/Bi.... We're psyched to see the interest of the community.