Saheli Sadanand's Avatar

Saheli Sadanand

@sahelisadanand

Deputy Editor at Nature Medicine | Handling & overseeing research in #Oncology #Immunology #Immunotherapy #InfectiousDiseases | Fan of vaccines, πŸ¦– & democracy | Views all mine

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Latest posts by Saheli Sadanand @sahelisadanand

Amidst the discussion of measles reestablishment in the US, the risk of rubella provides an instructive example of long-term delayed consequences that could resonate for decades ... or be stopped by coming to our senses 1/

04.05.2025 14:26 πŸ‘ 246 πŸ” 92 πŸ’¬ 8 πŸ“Œ 11
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Preventive vaccines for hereditary cancer syndromes - Nature Medicine An β€˜off-the-shelf’ neoantigen vaccine shows safety and immunogenicity in individuals with Lynch syndrome, further advancing hopes for preventive vaccines for hereditary cancer syndromes.

An β€˜off-the-shelf’ neoantigen #vaccine shows safety and immunogenicity in people with #Lynchsyndrome, advancing hopes for preventive cancer vaccines.
News & Views from Zsofia Stadler, Yonina Murciano-Goroff @ Memorial Sloan Kettering Cancer Center
https://www.nature.com/articles/s41591-026-04248-2

03.03.2026 18:30 πŸ‘ 0 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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A titan of vaccine development sees his field’s achievements slip away Stanley Plotkin, the 93-year-old "godfather of vaccines," is watching his field’s achievements slip away.

A doozy of a quote in this profile of the "godfather of vaccines" by @helenbranswell.bsky.social, as he watches his field trend in the wrong direction

β€œAll I can say is that I’m beginning to regret having lived so long β€” because we’re going downhill,”

www.statnews.com/2026/03/02/s...

02.03.2026 13:46 πŸ‘ 4 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

State vaccine requirements for school entry are absolutely essential if we have any hope of maintaining herd immunity.

It is madness for states to repeal these requirements. And vaccine exemptions should not be permitted unless for a documented medical contraindication.

04.02.2026 23:45 πŸ‘ 360 πŸ” 99 πŸ’¬ 14 πŸ“Œ 3
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The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system
www.nature.com/articles/s41...

02.02.2026 16:10 πŸ‘ 257 πŸ” 72 πŸ’¬ 10 πŸ“Œ 9
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Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial - Nature Medicine In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, en...

First evidence that healthy donor fecal microbiota transplant, added to immunotherapy, can enhance efficacy vs cancer
3 clinical trial reports (renal, small cell lung, melanoma)
nature.com/articles/s41...
nature.com/articles/s41...
nature.com/articles/s41...
Holy πŸ’©!

28.01.2026 15:31 πŸ‘ 148 πŸ” 36 πŸ’¬ 2 πŸ“Œ 0
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Tomorrow’s front page of the Minnesota Star Tribune: Jan. 23, 2026

22.01.2026 23:19 πŸ‘ 14689 πŸ” 7005 πŸ’¬ 393 πŸ“Œ 530
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US science after a year of Trump: what has been lost and what remains A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.

Trump has been in office for one year. We at @nature.com did a deep dive looking at the administration's disruption of science in numbers.

Take a lookβ€”the numbers are staggering. By me, @dangaristo.bsky.social, Jeff Tollefson, @kimay.bsky.social, & help from @noamross.net @scott-delaney.bsky.social

20.01.2026 18:08 πŸ‘ 505 πŸ” 318 πŸ’¬ 10 πŸ“Œ 30
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Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

A vaccine to prevent colon cancer.
Proof-of-concept for strong immune response and safety via neoantigens given to people carrying mutations for Lynch syndrome
nature.com/articles/s41...

16.01.2026 16:27 πŸ‘ 311 πŸ” 70 πŸ’¬ 7 πŸ“Œ 7

This study should never have been greenlit but glad it's been cancelled. @boghuma.bsky.social and The Guardian article below nicely summarize the key issues.

Leaked protocol with more discussion of all the problems with this trial: insidemedicine.substack.com/p/scoop-the-...

15.01.2026 15:43 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

My kitchen table issue is β€œdon’t shoot people at their kitchen tables”

07.01.2026 20:42 πŸ‘ 5490 πŸ” 835 πŸ’¬ 30 πŸ“Œ 34
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When it comes to vaccine schedules, the U.S. is now the outlier A STAT analysis of vaccine recommendations in 38 countries suggests the U.S. is now an outlier.

Did slashing multiple vaccines from the childhood vaccine schedule bring the US in line with other countries? In a word, no.
The US now recommends all kids be protected against fewer diseases than South Korea, Israel, Saudi Arabia, Taiwan & many more. www.statnews.com/2026/01/09/c...

09.01.2026 14:42 πŸ‘ 97 πŸ” 47 πŸ’¬ 1 πŸ“Œ 1

We saw Jan 6, 2021 and Jan 7, 2026 with our own eyes.
This is not Orwell's 1984.

08.01.2026 20:12 πŸ‘ 747 πŸ” 152 πŸ’¬ 14 πŸ“Œ 2
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How Unethical Research Seeds Medical Mistrust The absence of equipoise can turn research into harm

The planned hepatitis B birth-dose trial in Guinea-Bissau raises serious ethical concerns. Withholding a proven, life-saving vaccine from newborns to answer speculative questions is an absence of equipoise with real downstream harms for trust in vaccines.
bktitanji.substack.com/p/how-unethi...

18.12.2025 21:18 πŸ‘ 411 πŸ” 169 πŸ’¬ 15 πŸ“Œ 33

πŸ’―The mainstream media's coverage has contributed to how we got to this point.

05.12.2025 13:50 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Unlocking host response signatures in sepsis and critical illnesses - Nature Medicine Three studies that leverage blood-based gene expression data identify molecular and cellular host response signatures in sepsis and critical illnesses, opening a pathway to mechanism-anchored precision therapy.

Three studies that leverage blood-based gene expression data identify host response signatures in #sepsis and critical illnesses, opening a pathway to mechanism-anchored #precisiontherapy.
News & Views from Robert Stevens and Carl Harris @jhu.edu
https://www.nature.com/articles/s41591-025-04005-x

14.10.2025 16:30 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this yearβ€˜s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

08.10.2025 23:29 πŸ‘ 4729 πŸ” 1826 πŸ’¬ 142 πŸ“Œ 83
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The damage done - Nature Medicine When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

πŸ“° Please read this important news feature in @natmed.nature.com written by @marianneguenot.bsky.social

It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research

www.nature.com/articles/s41...

02.10.2025 00:19 πŸ‘ 6 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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Permethrin-Treated Baby Wraps for the Prevention of Malaria | NEJM Malaria remains a major cause of childhood death in sub-Saharan Africa. We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating t...

Ever since I learned about this study enrolling I have been eagerly awaiting the results. Researchers in Uganda took a centuries-old cultural practice mothers carrying babies on their backs in cloth wraps and turned it into a public health tool. You got to love it!
www.nejm.org/doi/full/10....

24.09.2025 21:13 πŸ‘ 337 πŸ” 120 πŸ’¬ 12 πŸ“Œ 9

Thanks for sharing, Mikki. Just wanted to note for anybody curious and/or in a similar position that babies can receive an MMR shot starting at 6 months.

19.09.2025 14:45 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

SO the people actively sowing distrust in vaccines (i.e. many of the people in RFK's new ACIP) are also saying that we need to change safe and highly effective vaccine schedules because of this same lack of trust. Make it make sense!

19.09.2025 14:19 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

ACIP voted 7-3 to NOT recommend MMRV combo vaccine for kids <4yo. Then in a confusing second vote (1 yes, 8 no, 3 abstentions - some citing confusion), they kept VFC coverage for the same vaccine they just said not to use.
This chaos matters for every family. 1/8

18.09.2025 22:50 πŸ‘ 78 πŸ” 31 πŸ’¬ 4 πŸ“Œ 6

Here's the upshot on hepatitis B vaccination at birth:
- it's extremely safe
- the earlier it's given, the better it protects against transmission from mother-to-child
- screening fails to capture many cases and is not done at all in many cases
- perinatal HBV infection is catastrophic

18.09.2025 18:40 πŸ‘ 278 πŸ” 103 πŸ’¬ 2 πŸ“Œ 0

A horrible horrible decision with NO rationale.

16.09.2025 15:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The Trump admin’s cruel disbanding of the Pediatric Brain Tumor Consortium My 12-year-old son died from brain cancer. The defunding of the Pediatric Brain Tumor Consortium will deny treatments to children like him.

On the Trump administration's cruel disbanding of the Pediatric Brain Tumor Consortium: my op-ed @statnews.com

My 12-year-old son died from brain cancer. This research would have helped children like him

www.statnews.com/2025/09/15/p...

15.09.2025 10:12 πŸ‘ 578 πŸ” 299 πŸ’¬ 16 πŸ“Œ 35
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Do NOT allow them to rewrite history with disinformation. #COVID vaccines worked remarkably well and allowed us to come out of a global pandemic. A picture is worth a thousand words.

28.08.2025 14:43 πŸ‘ 451 πŸ” 180 πŸ’¬ 5 πŸ“Œ 4
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GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/phase 2 trial - Nature Medicine In the final analysis of a phase 1/phase 2 trial of autologous GD2-targeting CAR T cells in pediatric patients with high-risk metastatic, relapsed or refractory neuroblastoma, treatment was overall we...

🌟Proud to publish these exciting data in #NatureMedicine -- final results from a phase 1/2 trial + a case series show strong efficacy of GD2 CAR-T cells in children with high risk #Neuroblastoma
#immunotherapy #OncSky #PedSky @natureportfolio.nature.com
www.nature.com/articles/s41...

21.08.2025 18:18 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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AAP's immunization recommendations are based only in the science, the needs of children, and the care that pediatricians have for the children in every community. If you have any questions about our recommended schedule, reach out to your pediatrician.
aao.org

20.08.2025 14:34 πŸ‘ 109 πŸ” 51 πŸ’¬ 8 πŸ“Œ 6
Health consequences of forced displacements from Gaza Discover the world’s best science and medicine | Nature.com

New and important #NatureMedicine correspondence on the health consequences of forced displacement in Gaza

"These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal."

www.nature.com/articles/d41...

15.08.2025 17:13 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Anti-PD-1 therapy in unresectable desmoplastic melanoma: the phase 2 SWOG S1512 trial - Nature Medicine In cohort B of the phase 2 SWOG S1512 trial, pembrolizumab monotherapy in patients with unresectable desmoplastic melanoma elicited a complete response rate of 37% and an objective response rate of 89...

🌟NEW in #NatureMedicine: Results from a phase 2 trial suggest that anti-PD-1 #immunotherapy should be the preferred treatment choice for patients with unresectable desmoplastic #melanoma -- complete response rate of 37% and a post hoc ORR of 89% (!!) #OncSky #MedSky

www.nature.com/articles/s41...

14.08.2025 15:30 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0