Lea H. Gregersen

Passionate about transcription?

🚀 We’re recruiting a PhD student in Transcriptional Regulation at @ucph.bsky.social Start Summer 2026

Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab @cgen2025.bsky.social

Meet us: gregersenlab.com

Apply by Apr 10, 2026👇
tinyurl.com/PhD-CGEN

The Vlaming lab continues to grow!
It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!

Great talk yesterday by @hilgerslab.bsky.social on RNA complexity in the nervous system @cgen2025.bsky.social @ucph.bsky.social mRNA isoform regulation occurs at multiple levels, with crosstalk between start and end of mRNA transcripts and serves a critical role to safeguard neuronal gene expression

Thank you to collaborators Gertrud Hjortø, @tcr-miller.bsky.social, and @jzylicz.bsky.social and support from colleagues at cgen2025.bsky.social

SCAF1 driven polyadenylation site usage regulates mRNA isoform expression and neuronal differentiation Accurate co-transcriptional processing is required for correct gene expression of mRNA transcript isoforms under unperturbed conditions, but particularly during development, to ensure tissue-specific ...

What is the function of the RNAPII-interacting SCAF proteins?

In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬 🧠

Loss of SCAF1 → shorter transcripts

📄 Interested in the full story? www.biorxiv.org/content/10.6...

A chance to join Fena’s group @fenaochs.bsky.social @cgen2025.bsky.social! Great lab and center - plus you will become our neighbour😉

Thank you to everyone involved and support from colleagues at @cgen2025.bsky.social and @ucph.bsky.social

Key takeaways:
🔍 Oxidative damage causes an instant shutdown of transcription, but unlike UV, without RNAPII degradation
🔍 Stalled RNAPII resumes transcription from within the gene body
🔍 PARylation controls early elongation restart
🔍 BER and SSBR repair enable RNAPII recovery in the gene body

This beautiful work, led by Quentin Thomas, revealed a surprising spatial organization of the transcriptional response:

🔬 Promoter regions: PARylation governs early RNAPII release
🔬 Gene body: DNA damage and repair drive RNAPII stalling

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to ...

What happens to transcription upon oxidative DNA damage? 🧬💥

RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦

👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...

Huge thanks to our amazing team and members within @cgen2025.bsky.social for fruitful discussions 🙌

What did we find? ✅ Elongation rates vary between genes ✅ …and within genes ✅ Histone marks & elongation factors correlate with rate subclasses

Existing methods either rely on indirect estimates or are limited to a handful of long genes. So we built DRB/TTchem-seq2: Short timepoint sampling, new computational framework 📈 leading to a ~7 fold increased individual gene elongation rates measurements!

Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇

Such a beautiful example of how tight control of transcriptional activity is achieved and even more important: plays a crucial developmental role. Congratulations @jzylicz.bsky.social and team!

❗️One more week to apply for a PhD position in our group👇

Gegersen Lab The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells

Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...

We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...

Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...

We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social

mbg.au.dk/en/news-and-...

Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology