Lille Neuroendocrinology

Alzheimer : découverte de l’implication de nouvelles cellules dans l’apparition et la progression de la maladie - Salle de presse de l'Inserm Les patients atteints de la maladie d’Alzheimer présentent des altérations biologiques communes, notamment une accumulation anormale de la protéine Tau dans le cerveau. Les mécanismes derrière cette a...

Nos découvertes soulignent l'importance des cellules non neuronales spécialisées, appelées tanycytes, en tant que cible thérapeutique potentielle pour maintenir notre cerveau en bonne santé et retarder ou prévenir la progression de la maladie d'Alzheimer ✨🧠

presse.inserm.fr/alzheimer-de...

These brain cells clear proteins that contribute to Alzheimer’s When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

Check out the comment on our recent publication on how Tanycytes mediate the clearance of pathological Tau in Alzheimer's Disease!
We hope our discoveries spark new research avenues and innovative treatment strategies 🧠

www.nature.com/articles/d41...

How AI is being used in war — and what’s next The conflict in Iran is highlighting the use of artificial intelligence in warfare.

The escalating conflict between the United States, Israel and Iran has thrown a spotlight on the use of artificial intelligence in warfare

go.nature.com/4lkaf0w

Thrilled to announce the publication of our latest research revealing an unexpected role of tanycytes🤩. Our team, led by Florent Sauvé, has uncovered how these cells meditate clearing of pathological Tau, a key player in Alzheimer's disease 🧠

www.cell.com/action/showP...

#Neuroscience #Tanycytes

grpahical abstract

Brain-clearing cells offer clues to slowing Alzheimer’s disease progression. spkl.io/63321Aax6T

@cellpressblue.bsky.social
Vincent Prevot & colleagues

🧠✨ Conférence grand public : Le duo cerveau & obésité

Venez explorer les liens entre le cerveau et l’obésité lors de ma conférence grand public @pasteurlille.bsky.social !

🎨 Exposition photo : "Voyage au cœur de l’hypothalamus"

@neuroendolille.bsky.social @semaineducerveau.bsky.social

New data identify tanycytic cilia as key sensors regulating energy balance in a sex-dependent manner www.biorxiv.org/content/10.6...

✨Happy New Year 2026!✨

May 2026 be filled with mind-blowing scientific discoveries, collaborations, and exciting projects 🥳🥳

We warmly thank all our colleagues and collaborators for their continued trust and commitment

🚀 Looking forward to another year of scientific progress and collaborations!!

Our patent on GnRH & Cognition has been granted in Japan—the first country to accept our invention. A milestone for our lab and the launch of our startup, GnRHope, dedicated to translating research findings into solutions. Huge thanks to the team, collaborators, and supporters who made this possible

🔬Our lab is featured this month in “Les Échos de l’Europe” by INSERM and the French Ministry.

Huge thanks to all our collaborators and partners who make quality research possible every day!

www.calameo.com/read/0051544...

#Research #HealthInnovation #INSERM #Europe #Science #TeamWork

Le grand invité Politique, culture, économie, religion ou société, Michel Picard reçoit en direct un grand invité issu des Hauts-de-France pour éclairer un point de l'actualité.A retrouver en vidéo sur notre chaine Y...

À l’occasion du colloque SF-DOHaD au @chulille.bsky.social de Lille,
@alicia-mayeuf.bsky.social a été interviewée sur RCF Radio pour parler des 1000 premiers jours et de leurs enjeux pour la santé 🎙️🌟
www.rcf.fr/actualite/li...

Fasting boosts breast cancer therapy efficacy via glucocorticoid activation - Nature Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting to reduce harmful effects.

Therapies to mimic the metabolic effects of fasting might improve the effectiveness of hormone treatments for breast cancer, according to a study in Nature. The research finds that the metabolites associated with fasting can boost anti-tumour properties involved in some cellular pathways. #medsky 🧪

⭐Our team participated in the National Alzheimer’s Congress in Paris.

The brilliant presentations from Vincent Prevot and Thibaud Lebouvier put on the table tanycytes as underexplored players in AD, and GnRH and it's role in cognition. Fresh angle to tackle an old disease 👊 🧠

Remarkable talk given by @sreekalasn.bsky.social from our lab highlights #endometriosis as an important topic at the inaugural @France2030 “Women and Couples’ Health” symposium 2025 in Paris! 🌟 @LilleNeuroscience&Cognition @chulille.bsky.social
@univlille.bsky.social @inserm.fr

Proud of PaoloGiacobini, a brilliant member of our lab who delivered an outstanding talk at the inaugural @France2030 “Women and Couples’ Health” symposium 2025 in Paris! 🌟 @chulille.bsky.social, @inserm.fr @univlille.bsky.social

Estrogen modulates reward prediction errors and reinforcement learning - Nature Neuroscience Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.

Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...

#blueprint 1/7

Targeting Vascular Barriers – BBB and Beyond Symposium at the Faculty of Medicine, Rouen (IRIB) was such a great opportunity to catch up on exciting novel research in vascular barriers and BBB-related mechanisms 🤩
Big thanks to Ebba Brakenhielm and Bruno Gonzalez for such an enriching event!

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period The melanocortin circuit of the hypothalamus is crucial for regulating energy balance, but the development of this circuit is incompletely understood. This study in mice shows that activity and vesicl...

Oxytocin isn’t just the “love hormone”: it helps wire the brain’s metabolic circuits! 🧠
In our new @plosbiology.org study, we show that OT neurons guide the postnatal development of POMC and AgRP pathways that control energy balance

Budget 2026 : audition du ministre de l'enseignement supérieur 29 octobre 2025

La baisse des budgets de recherche et l’affaiblissement des moyens alloués à l’enseignement supérieur menacent la souveraineté scientifique de la France. Sans investissements ambitieux, comment préserver notre capacité à innover ? #Recherche #ESR #Budget2026

videos.senat.fr/video.558293...

Belle rencontre de travail avec Maître Paul-Alexandre Janssens Avocat d’affaires, et Laurent Bonduelle.
La volonté partagée d’excellence ouvrent des perspectives prometteuses pour découvrir les traitements de demain. 🧠💡
#Recherche #Innovation #Santé

Tanycytes: bloodhounds of the metabolic brain Constant monitoring and fine-tuning of internal body status to maintain energy homeostasis despite changing physiological needs and environmental cond…

Hungry to know about the incredible tanycytes? Check out our latest review article "Tanycytes: bloodhounds of the metabolic brain"👌
www.sciencedirect.com/science/arti...

Budget 2026 : « La taxation des expérimentations animales mettrait en péril la recherche en France » TRIBUNE. Dans une tribune au « Monde », des représentants de sociétés savantes, de fondations, d’associations et de réseaux scientifiques mettent en garde contre le dépôt d’amendements au projet de lo...

"En France aussi, la liberté académique subit des attaques politiques depuis plusieurs années, notamment avec l’émergence de groupes d’intérêt (...)"

www.lemonde.fr/sciences/art...

The search for mutations that sperm acquire as men age Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring.

Age-related mutations give sperm-forming stem cells a selective advantage during sperm production, shaping disease risk and genetic variation in offspring

go.nature.com/4hlCBFH

🎉 Honoured to have delivered the Ernst Knobil Distinguished Lecture! Huge thanks to Ludmila Filaretova for the warm and thoughtful introduction, and to everyone who joined—your energy made it unforgettable! So excited about the bright future of integrative physiology! 🚀 #IUPS #GnRH #Cognition

🔬💡 Sreekala Nampoothiri and Konstantina Chachlaki, two early career researchers, and Ariane Sharif, senior researcher from our team have just secured funding from the
@AgenceRecherche
! 🎉 Huge congrats to all three — exciting projects on the hypothalamus ahead 🧠

Annonce des équipes lauréates des consortiums de recherche sur l'endométriose et l'infertilité - PEPR-SAFE Découvrez les équipes lauréates des consortiums de recherche sur l'endométriose et l'infertilité du programme de recherche SAFE.

🎉Félicitations à notre laboratoire pour son engagement dans deux nouveaux consortia PEPR sur la fertilité des femmes! Un grand pas vers l’innovation et la recherche au service de la santé des femmes. 🚺🔬 @NeuroendoLille @CognitionLille @univ_lille pepr-sante-femmes-et-couples.fr/2025/06/27/a...

Exploring tanycytes for targeted drug delivery to the brain Delivering drugs to the brain is one of the biggest challenges in modern medicine. The T-GATE projects aims to use tanycytes to do this.

🔑 The T-GATE project explores how tanycytes—specialized cells at the blood-brain barrier—can help deliver drugs for metabolic & neurological disorders. Bridging neuroscience and drug discovery! 👌More: projects.au.dk/open-odin/it... #ODIN #Neuroscience #DrugDiscovery

Serge Luquet

Huge congratulations to Serge Luquet on receiving the Silver Medal from @CNRS! So well deserved 👏🏻
www.insb.cnrs.fr/fr/personne/...

Thrilled to visit the Peking University Neuroscience Research Institute, thanks to the kind invitation from Hong Jiang! Her impressive research since returning from the Cologne Max Planck Institute for Metabolic Research is truly inspiring. #Hypothalamus #Research

Tanycytes and GnRH in the spotlight at the Cell Symposium on Neurometabolism in health and disease in Shenzhen, China. And congrats to Alicia Sicardi for getting the poster award 🥇