Cansu Koyunlar

Hematology Lectures on line!
Monday March 9th at 16.00 CET we have:
Ami Bhatt, Stanford University with "From precise microbiome genomics to precision medicine".
us06web.zoom.us/j/84273660925
Also look at all the other speakers we have this spring.
Please, spread the news!

We are hiring!

Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se.

If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out!
#hiring #sciencejob #STEMJobs

Register now for the second Hubrecht Symposium, themed Molecular Machines in Development in Utrecht on March 26, 2026.

Visit hubrecht.eu/hubrecht-symposium-2026/ for registration and abstract submission.

Abstract submission deadline: February 1, 2026.

Even more exciting, we find that other AML drivers—like NUP98 and KMT2A fusions—coerce their own “majestic creatures” into the same C-body nightmare, revealing a shared structural logic behind clinically similar leukemias. See the original thread ⬇️ for more insights.

Disparate leukemia mutations converge on nuclear phase-separated condensates Mutant NPM1 and various leukemia oncofusions form biophysically indistingishable nuclear condensates, termed C-bodies, which orchestrate leukemogenic gene expression. These findings consolidate divers...

And here’s the twist we uncover in the new work ⬇️: the gremlin’s power was never in the cytoplasm at all. NPM1c must act *in the nucleus* through phase separation, bringing together multiple proteins on chromatin to drive AML... Overturning years of assumptions.

Incredibly excited to receive an ERC Consolidator Grant. This recognition means a lot for what we’ve built so far and for what’s ahead.

Thank you to all collaborators and supporters.

Looking forward to getting this project going!

Doctoral INPhINIT fellowships - Incoming Call 2026 We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

Outstanding PhD fellowship call OPEN for excellent students.

lacaixafoundation.org/en/doctoral-...

This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).

If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!

If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)

A Painting of a rather potatoesque fish. The fish is yellow, with red dots and red eyes, and pink fins. It is swimming in blue algae

Yayoi Kusama was doing this in the 60s. What a legend.

("Midnight fish", Y Kusama)

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

Amazing! Thank you 😊

Does anyone know of a good textbook/review broadly on erythropoiesis? I'd love to hear your suggestions! 🩸 #hemesky #bloodsky

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

New method 🚀: scEpi2-seq lets us read DNA methylation+histone marks in the same single cell. Found that methylation “memory” after replication depends on chromatin+histones, and TF promoters repressed by H3K27me3 carry distinct methylation. So stoked to share this as first+co-corresponding author 🎉

Come visit my poster #3195 tomorrow, so I can tell you about the method we recently developed to study DNA replication dynamics and replication stress in hematopoietic tissues!

Extremely excited to be in Kumamoto for #ISEH2025 and to share our work! We had a great start today with the new investigators workshop, and I cannot wait for the coming days! @isehsociety.bsky.social 🍡

💯💯💯💯💯💯💯

Enjoy Dorien! 😊 Also, v cool bike! 🌟

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

We've updated our biorxiv! Check it out if you're interested in a new technique co-profiling RNA and epigenetics in single cells, extended gastruloid culture, and our proposed model for an epigenetic timer determining sequential perceptiveness to different lineages! ➡️ www.biorxiv.org/content/10.1...

A collection of cookies shaped like media bottles, each decorated with icing to resemble various STEMCELL media such as "TeSR-AOF, TeSR-E8, mTeSR Plus, and eTeSR".

Finally, media you can *actually* eat! 😉🍪

If you want to know about Blood Stem Cell Aging, then THIS is the meeting to go to.
I will be presenting the latest results of the Fraticelli Lab regarding HSC memories and clonal dynamics.

JOIN US !!!!!

ehaweb.org/connect-netw...

SO COOL!! 👀

Ina Sonnen earned tenure: 'science is like a puzzle' - Hubrecht Institute

What if science is like solving puzzles?

We spoke with @sonnenlab.bsky.social, a group leader who recently received tenure. She tells us about her journey, her research on signaling dynamics, and the challenges of leading a lab.

Read her inspiring story here 👇 www.hubrecht.eu/ina-sonnen-t...

Remembering James Till, 1931-2025 It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...

Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...

Hallmarks of stem cell aging As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

In a mouse model for GATA2 deficiency, leukemia emerges from BMF. buff.ly/WPLVTrt #hemesky

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

Congrats Dorien, big milestone! 😊