Juha Hulmi

Our new study is now published in Advanced Science

We show that skeletal muscle retains a molecular memory of disuse

Young muscle shows transcriptional resilience

Aged muscle shows exaggerated vulnerability

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism mTORC1 does not always hold the key to unlocking the mechanical load-induced growth of skeletal muscle.

Increase in fiber cross-sectional area was mediated through a rapamycin-sensitive signaling pathway, whereas longitudinal growth, marked by the in-series addition of sarcomeres, was mediated through a rapamycin-insensitive signaling pathway.

www.science.org/doi/10.1126/...

Prespecified analysis plans are not suitable for exploratory experimental physiology research Click on the article title to read more.

"Prespecified analysis plans are not suitable for exploratory experimental physiology research"

physoc.onlinelibrary.wiley.com/doi/10.1113/...

@abigailmackey1.bsky.social

Edoardo Lecce, Paolo Amoruso, Francesco Felici and Ilenia Bazzucchi (Department of Movement, Human and Health Sciences, University of Foro Italico) #review the #resistance training-induced #adaptations in the #neuromuscular system.

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Preprint: mRNA transcription in skeletal muscle drives growth and determines nuclear accretion

www.biorxiv.org/content/10.6...

Thank you for this honor and congrats @smantyselka.bsky.social!

Congrats to Sakari Mäntyselkä, et. al, for the #APSselect paper "Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth" in @AJPCellPhys
@juhahulmi.bsky.social @JYUBiolPA

https://ow.ly/Ewtv50XFNhq

@apspublications.bsky.social

Open access here:
journals.physiology.org/doi/full/10....

@smantyselka.bsky.social @riikka-k.bsky.social

Repeated Resistance Training Reveals the Reproducibility of Muscle Strength and Size Responses Within Individuals This study investigated whether the responses of upper and lower limb muscle strength and size to resistance training (RT) are reproducible across two RT periods. Untrained males and females (age 32 ....

New study! Those who responded well to resistance training did quite well also in the second training after a training break. So some people seem to be physiologically more talented. But the individual nature of training adaptations are still overexaggerated.

onlinelibrary.wiley.com/doi/10.1002/...

Hormone Profiles After Planned Low Energy Availability Exposure in Naturally Menstruating and Hormonal Contraceptive Using Physique Athletes This observational study investigated the potential influence of hormonal contraceptive (HC) use on selected hormonal biomarkers (estradiol, total testosterone, IGF-1, cortisol, triiodothyronine, an.....

Exogenous hormones in combined hormonal contraceptive users may maintain already suppressed hypothalamic–pituitary–ovarian axis function in the presence of low energy availability in athletes.

@ritutm.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...

@jphysiol.bsky.social

Liikuntaharjoittelun yksilöllisyys kansainvälisen konferenssin pääteemana Jyväskylässä 19.–21.11.2025 Miksi toiset kehittyvät liikuntaharjoittelussa nopeammin kuin toiset? Miten perimä vaikuttaa harjoittelun tuloksiin? Muun muassa näihin kysymyksiin kuulet vastauksia Jyväskylässä järjestettävässä kansainvälisessä valmennustieteen konferenssissa.

Miksi toiset kehittyvät liikuntaharjoittelussa nopeammin kuin toiset? Miten perimä vaikuttaa tuloksiin? Tule kuulemaan uusinta tutkimusta Jyväskylään 19.–21.11.! Ilmoittaudu normaalihinnalla 31.10. mennessä 👉
www.jyu.fi/fi/uutinen/l...

Great work by the first authors @smantyselka.bsky.social and @erikniemi.bsky.social 😊

Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles Skeletal muscles and blood vessels are continuously exposed to mechanical forces, particularly during exercise. We subjected human endothelial and skeletal muscle cells to cyclic mechanical stretch an...

Our new study together with @juhahulmi.bsky.social shows that:

Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles
@wrihelsinki.bsky.social

www.biorxiv.org/content/10.1...

Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪

In this #JournalClub, Igor Longobardi of uspoficial.bsky.social et al. examine the work of Hulmi et al. (2025) and what is next for the ‘muscle memory’ conundrum? ✍️

🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Thanks for sharing Craig! I am still grateful for introducing your labs in Victoria Uni! Welcome to Jyväskylä, Finland some day!

I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle

Infograph:

Great work from my PhD student:
@smantyselka.bsky.social

Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society Skeletal muscle is the main consumer of glucose after a mixed meal, and resistance exercise further increases muscle glucose uptake. Emerging evidence suggests that glucose uptake in muscles is not on...

New study from our lab! Human muscle cells incorporate glucose into proteins, RNA, and lipids, and anabolic stimulation further increased these processes. Resistance training increased metabolites and enzymes of these processes, e.g., PHGDH, which was shown to be anabolic.
tinyurl.com/2744e22s

Elite strength and physique athletes differ in sport-specific muscle size and power. In these athletes, the muscle size contributes to muscle strength. Finally, females have better strength endurance than males, independent of the training background. tinyurl.com/39dfz977

Muscle memory of exercise optimizes mitochondrial metabolism to support skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society Exercise protects against age-related declines in skeletal muscle mass and function while improving overall health. Exercise can also prime long-term muscle health to enhance adaptations upon exercise...

Researchers investigated muscle memory of exercise in mice and the results suggest that skeletal muscle retains a metabolic memory of endurance exercise, which enhances adaptations following retraining:
journals.physiology.org/doi/full/10....

Metabolic signature of short‐term low energy availability Exposure to low energy availability (LEA) can potentially detrimentally affect athletes' health and performance. Timely identification is crucial, yet its detection is often delayed until severe symp...

Our findings provide new insight into the metabolomic signature of low energy availability (LEA) and support metabolomics as a tool for early detection of LEA.
physoc.onlinelibrary.wiley.com/doi/10.14814...

2 min video of our recent study in J Physiol. physoc.onlinelibrary.wiley.com/doi/10.1113/...

The link below:

Individual responses to exercise training as the main theme of an international conference in Jyväskylä, November 19–21, 2025 Why do some people progress faster in exercise training than others? How can training responses be predicted, and how does genetics influence the outcomes of training? These questions are addressed at the international coaching science conference.

Why do some progress faster in resistance training? 💪
How do genetics and physiology shape training responses? 🏋️‍♀️
Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference.
www.jyu.fi/en/news/indi...

Thanks for the comment @atanas-g-atanasov.bsky.social. That was our goal in our proof-of-concept research.

Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth | American Journal of Physiology-Cell Physiology | American Physiological Society Skeletal muscle atrophy in response to pathophysiological stimuli or disuse includes loss of muscle mass and strength. Targeting signaling pathways regulating muscle growth can counteract muscle loss,...

Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth
journals.physiology.org/doi/abs/10.1...