Center for Systems Biology Dresden

Two-panel calibration plot (two benchmark dimer datasets) comparing predicted interchain contact-probability bins (x-axis) with the observed fraction of native interfacial contacts (y-axis). Points follow the diagonal, indicating close agreement between predicted probabilities and true interface-contact fractions.

My first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers.

www.biorxiv.org/content/10.6...

#proudPI moment: this afternoon, my first student, Maryam Setoudeh, successfully defended her #PhD thesis @tudresden.bsky.social.

Picture of happy student and inanely grinning PI provided by @zhaoshh.bsky.social.

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

The Division of Biological Physics @mpipks.bsky.social seeks a Research Group Leader in #biophysics, #softmatter physics, or related areas. (Further particulars in the ad.)

Apply by the 3rd of April 2026 at pks.mpg.de/bprgl to join us in Dresden!

Our work @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de @scadsai.bsky.social fuses representation learning with spatial statistics @iclr-conf.bsky.social enabling #AI for spatial localization patterns: openreview.net/forum?id=09Y...

2026 marks the 25th Anniversary of @mpi-cbg.de in Dresden. We invite all Alumni to reconnect and celebrate 25 years of science together August 24-25. Sign up, if you would like to receive further updates, formal registration will follow: www.mpi-cbg.de/25th-anniver...

Come and join our Discrete Laplacian workshop in Dresden, Germany 🙌!

With Karel Devriendt, Otto Sumray, and Giulio Zucal, we are organising the workshop in MPI-CBG, 22-25 Jun 2026.
Thanks to the support from Heather Harrington's group at CSBD, MPI!

Abstract ddl: 1 Mar 2026

More details follow 🧵

Giulio from the group of Türkü Özlüm Çelik talks on mathematical structures during our current coffee chalk talk series @csbdresden.bsky.social @math-mpicbg.bsky.social to promote knowledge exchange between disciplines.

The spring call for the ELBE Postdoctoral Fellow Program is now open. We look forward to receiving your applications by March 13, 2026!
Further information can be found here:
www.csbdresden.de/join-us/jobs...

Snowy day @mpi-cbg.de and @csbdresden.bsky.social. ❄️❄️❄️

How does an elastic line buckle within a curved surface? The answer, by @zhaoshh.bsky.social and @lepuslapis.bsky.social @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social, has now been #published @physrevlett.bsky.social:

doi.org/10.1103/63py-ph5s

Protein plasticity and evolution: The research group of Agnes Toth-Petroczy at MPI-CBG YouTube video by MPI-CBG

Watch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...

Robust variable selection for spatial point processes observed with noise We propose a method for variable selection in the intensity function of spatial point processes that combines sparsity-promoting estimation with noise-robust model selection. As high-resolution spatia...

Modeling spatial point patterns from noisy, incomplete experimental data just got easier! Great work by @domsturm.bsky.social for sparse, noise-robust model inference of point processes 🤩 @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de Preprint out now: arxiv.org/abs/2510.25550

Greeted this morning with the blackboard of math discussion— looks like algebra, topology and data— during tea yesterday @csbdresden.bsky.social @mpi-cbg.de

With her research group, “Algebraic Topology and Networks in Biology,” Daniela Egas Santander joins @mpi-cbg.de and @csbdresden.bsky.social. Welcome, Daniela! 🎉 @math-mpicbg.bsky.social www.mpi-cbg.de/news-outreac...

A new call for the ELBE Visiting faculty program is now open! No matter if you are junior or senior faculty, if you work on math/physics/computer science/ML applied to life sciences, you are welcome to submit an application to come and collaborate with the groups at CSBD! Deadline is November 30th.

Welcome to @mpi-cbg.de, @mpipks.bsky.social and @csbdresden.bsky.social, Fridtjof!

TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter We present a topology grounded, multiscale simulation platform for morphogenesis and biological active matter. Morphogenesis and biological active matter represent keystone problems in biology with ad...

🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905

Two years today! Very grateful 🙏 @mpi-cbg.de @csbdresden.bsky.social @math-mpicbg.bsky.social

New Perspectives on the Hidden World of Proteins  Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy

Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...

🤩🤩🤩Absolutely thrilled our work is featured in the Magazine of @maxplanck.de ! Big thanks to the writer and editor 🙏🙏🙏 Never saw our work described so well! Curious? @csbdresden.bsky.social @tudresden.bsky.social @mpi-cbg.de - PDF is freely available, article starts p.36: www.mpg.de/25430399/MPR...

Now #published @pnas.org: "A model for boundary-driven tissue morphogenesis", a great #biophysics #devbio collaboration led by @danielalber.bsky.social @zhaoshh.bsky.social:

doi.org/10.1073/pnas.2505160122

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social @flatironinstitute.org

🙏 Very honored to speak at #BuildingBridges2025 on #AI for #Biomedicine. What an amazing lineup of panelists 🤩🤩🤩 Politics and Science working together- Germany, Lithuania, Czech Republic, Poland - together for future #AI 👍🏼 @hzdr.bsky.social @csbdresden.bsky.social

Another #preprint: "Elasticity and plasticity of epithelial gap closure", from the #PhD work of Maryam Setoudeh:

arxiv.org/abs/2509.05110

This one required a lot of (I think) beautiful #mechanics!

@mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social

Cool paper out by mathematicians studying population dynamics with algebraic geometry @georgysch.bsky.social @mpi-cbg.de @csbdresden.bsky.social @math-mpicbg.bsky.social

Strata of Ecological Coexistence via Grassmannians We study the Lotka--Volterra system from the perspective of computational algebraic geometry, focusing on equilibria that are both feasible and stable. These conditions stratifies the parameter space ...

New #preprint: "Strata of Ecological Coexistence via Grassmannians" with Türkü Özlüm Çelik, Georgy Scholten, Kexin Wang, Giulio Zucal - a great, first collaboration with #mathematics @csbdresden.bsky.social @math-mpicbg.bsky.social:

arxiv.org/abs/2509.00165

@mpi-cbg.de @mpipks.bsky.social

#GenAI meets perception psychology for better super-resolution microscopy 🤩 Fig.1 says it all! 😎 Fantastic collaboration with @casusscience.bsky.social - work of @zuseschoolsecai.bsky.social students @csbdresden.bsky.social - out now onlinelibrary.wiley.com/doi/10.1002/...

Morphogen gradients are regulated by porous media characteristics of the developing tissue Summary: Image-based 3D modeling of pore-scale extracellular space geometries of the developing zebrafish embryo reveals that the Fgf8a morphogen gradient is regulated by the porous media characterist...

⚡️Advanced Computing ❤️ laboratory experiments ➡️ an unbeatable combination to unlock the secrets of biology! Together with the Brand lab @tudresden.bsky.social we @csbdresden.bsky.social discovered a simple mechanism how tissue geometry controls growth: journals.biologists.com/dev/article/...

Integrating Odeint Time Stepping into OpenFPM for Distributed and GPU Accelerated Numerical Solvers We present a software implementation integrating the time-integration library Odeint from Boost with the OpenFPM framework for scalable scientific computing. This enables compact and scalable codes fo...

Our scientific computing framework #OpenFPM now has multistage and adaptive time integrators that scale to distributed CPU clusters and GPUs! Happy supercomputing! @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de preprint: arxiv.org/abs/2309.05331

We are looking for a new Max Planck Director in Biomedical #AI here at @csbdresden.bsky.social @mpi-cbg.de. Excited and looking forward!

Tiny swimmers YouTube video by MPIPKS

🐠🦠Why can’t bacteria swim like fish?
At microscopic scales, physics changes — viscosity rules! Researchers at our institute study how microbes like E. coli overcome this challenge with clever strategies like run-and-tumble.

Watch our new video:

youtu.be/drwCRRD7CGY?...