New online! Reverse vaccinology 3.0
11.03.2026 17:33
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I wrote a primer on AI antibody design, published on Asimov press.
www.asimov.press/p/antibody-d...
These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social
www.sciencedirect.com/science/arti...
Images of molecular models of ALG3 and ALG9 proteins with substates bound.
I’m very excited to share some newly published work that uncovers the molecular basis for oligomannose synthesis!
www.nature.com/articles/s41...
Hot off the press!
I'm thrilled to share that our paper "Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM" has been published!
Link to the paper: www.pnas.org/doi/10.1073/...
Nature is full of remarkable protein nanomachines, and now we can watch one more in action.
The parasite that causes malaria exports hundreds of proteins to remodel the cells that it infects. #ASBMB2026 #ASBMB26
More on Malaria Parasite PTEX at PDB-101:
Structural basis for Rep-mediated adeno-associated virus packaging pubmed.ncbi.nlm.nih.gov/41790558/ #cryoEM
🚨 new paper alert 🚨
Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens:
bit.ly/4u8UxJl
A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate.
Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...
deze is voor jullie (verwacht: augustus) 👀
Lenacapavir prevents production of infectious HIV-1 by abrogating immature virus assembly. www.biorxiv.org/content/10.64898/2026.03.02.709178v1 #cryoEM
Jouw tandarts, fysiotherapeut of opticien kan momenteel onderdeel zijn van een internationale investeerder. Private equity koopt in hoog tempo zorginstellingen op, met goedkeuring van de overheid. Maar wat betekent dat voor de prijs, kwaliteit en onze keuzevrijheid als het op zorg aankomt?
The results are finally in! 🏆💻🧬
I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵
Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.
Stunning new structural analysis and mechanism for Tmn anti-phage defense by @fnobrega.bsky.social
www.biorxiv.org/content/10.6...
Now online! High-resolution in situ structures of hantavirus glycoprotein tetramers
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
The March Molecule of the Month looks at Lenacapavir, a potent and long-acting drug that targets the HIV capsid #ASBMB2026
Cryo-EM structures of prefusion HSV-2 gB in complex with human antibodies.
Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!
High-resolution in situ structures of hantavirus glycoprotein tetramers pubmed.ncbi.nlm.nih.gov/41763200/ #cryoEM
CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs pubmed.ncbi.nlm.nih.gov/41754567/ #cryoEM
Dit gaat niet over het ietsiepietsie aanpassen van koopkrachtplaatjes, dit gaat over het fundamenteel niet verstaan van het tijdsgewricht.
Column over het #coalitieakkoord
Vandaag gratis te lezen
www.groene.nl/artikel/aanv...
In new study we examine constraints on evolution of endemic "common-cold" coronavirus 229E
We find strong tradeoff between antibody neutralization & receptor binding, due to up-down position of spike RBD
www.biorxiv.org/content/10.6...
See lead author Sheri Harari's summary: x.com/SheriHarari/...
Out today in @natecoevo.nature.com!
📝 www.nature.com/articles/s41...
We compare the mutational tolerance of enteroviruses A & B across their full proteomes, mapping distinct host interaction strategies 🦠 and identifying mutation-resistant regions that could inform antiviral development 💊
Cynthia in action 😎
Happening now, looking forward to the talks!
In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens.
www.pnas.org/doi/10.1073/...
Structural insight into the assembly and D antigenicity of polio type 1 stabilized virus-like particles pubmed.ncbi.nlm.nih.gov/41735326/ #cryoEM
Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA
