Rosado lab

We are celebrating our research institute @cabimer.bsky.social 20th anniversary!! Superb list of speakers!! And attendees!!

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

www.nature.com/articles/s42...

Congrats @jourdainlab.bsky.social & team!!

Congrats Felipe! I hope this is one of just many more to come!!

Muere a los 91 años la etóloga británica Jane Goodall La etóloga británica Jane Goodall ha fallecido a los 91 años de edad en la ciudad estadounidense de...

#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall

Great work David! Congratulations to you and your team!

A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!!
Please RT!!

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

Totally left!!!

Congratulations!!

S-phase checkpoint protects from aberrant replication fork processing and degradation Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics
‪@oncodeinstitute.bsky.social‬,
‪@nkinl.bsky.social‬

This is figure 2, which shows influenza A virus infection promotes dormant DCC proliferation and phenotypic change.

A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:

My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...

🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte
📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023
👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social
🧵

Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...

What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇

UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species

ubibrowser.bio-it.cn/ubibrowser_v...

#NucAcisRes 2022
academic.oup.com/nar/article/...

What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social

Published today:

www.nejm.org/doi/full/10....

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi El hallazgo ha sido liderado por el departamento de Genética de la Universidad de Sevilla y el Instituto Cabimer

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...

I'm super excited to announce that registrations are now open for the 19th Australian Cell Cycle, DNA Repair and Telomere Workshop. Awesome international speaker line-up, with plenty of locals being invited! Book now to secure your earlybird rate. www.australiancellcycle.org

Massively parallel jumping assay decodes Alu retrotransposition activity - Nature Communications Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.

Massively parallel jumping assay (MPJA) enables to test the jumping potential of thousands of transposons. Analysis of >160,000 Alu haplotypes identified transposition-asssociated domains. Amazing work by Navneet Matharu, Jingjing Zhao, Martin Kircher and many others.
www.nature.com/articles/s41...

¿Quieres investigar sobre el desarrollo tumoral causado por las proteinas que se pegan en el ADN y provocan inestabilidad genética? Entonces solicita #JAEIntro JAEINT25_EX_0519!!

Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!