Making "AI Scientists" has become a hot topic lately. The first reference I could find was from 2008. The term has been used for 20 years! Like "Adam," an AI Scientist robot for studying yeast was published in 2009. I wrote a short post about the term and what it means now.
diffuse.one/p/w1-001
Meet our new Future Leader Fellows!π
Introducing @mbourdenx.bsky.social, Dr Sophie Morse & Dr Wioleta Zelek who have been awarded prestigious Future Leader Fellowships from @ukri.org β¬οΈ
Read more about their workπ buff.ly/JOH2d9N
π€ Could an AI scientist help unlock the secrets of dementia?
Dr @mbourdenx.bsky.social (@ukdri.ac.uk at UCL), is working with @futurehousesf.bsky.social to explore how AI is transforming research.
buff.ly/O8RjZIX
#UCLDementia #WorldAlzheimersMonth
Huge congratulations to Dr @angelikaza.bsky.social and Dr @mbourdenx.bsky.social who have both been awarded @ukri.org Future Leaders Fellowships! π @uclqsion.bsky.social @ukdri.ac.uk
Find out about their exciting projects: www.ucl.ac.uk/brain-scienc...
βUltimately, I see AI leading to an acceleration in discovery in dementia research that could be transformative for patients" says Dr @mbourdenx.bsky.social @ukdri.ac.uk, who is working with an "AI scientist", a system that can analyse data and suggest new research directions not yet explored
Iβm very happy π₯³ to share our new collaborative work, out today in Science Advances! Many thanks to all the co-authors!
Differential pathological dynamics triggered by distinct Parkinson patientβderived Ξ±-synuclein extracts in nonhuman primates | Science Advances www.science.org/doi/10.1126/...
It must be an April foolβs prank
"The biggest mystery is not why arXiv succeeded. Rather, itβs how it wasnβt killed by vested interests intent on protecting traditional academic publishing."
www.wired.com/story/inside...
I like that there is a camera just next to the sign β¦ big brother is watching you!
RNA xkcd.com/3056
Sur les retraites, Bayrou a menti.
Le "dΓ©ficit cachΓ©" des retraites nβa jamais existΓ©.
Pour justifier son refus d'abroger la rΓ©forme des retraites, il avait inventΓ© un dΓ©ficit de 55 milliards en 2030.
La Cour des comptes dit que ce sera 5 fois moins. Maintenant : abrogation.
The ground truth for AD is a bit of a debate recently, to say the least! But I am a big fan of the intersection between a clinical diagnosis and a biological definition.
- we need to learn from system biology regarding the interpretation of gene hits. For too long we have relied on imprecise tools (gene ontology) that are often wrongly annotated and cannot sufficiently account for the redundancy of biological systems or the existence of feedback loops
Interesting read! Some thoughts: - a GWAS is only as good as the patient inclusion. There has been immense efforts for AD on that aspect, even doing small postmortem GWAS on path confirmed cases
- the absence of a coherent picture at the gene level might indicate multiple disease mechanisms
π¨Cool Job Alert π¨consider joining this amazing and rocknroll lab
Tesla paid $0 in federal income tax last year.
2022: $0
2021: $0
2020: $0
2019: $0
2018: $0
Tesla reported $6.7 billion in profit in those years.
New in @naturecomms.bsky.social: I'm thrilled to share with you our latest work that applies #srRNAseq to understand splicing accuracy across human introns, tissues and in the context of ageing and neurodegeneration www.nature.com/articles/s41...
After spending 4 years in the USA for my postdoc and my daughter being born there, it always felt (and still feels like!) a second home. So itβs utterly sad to see whatβs happening now. I stand with all my American friends! Resist βπͺ
Notre programme est prΓͺt.
Nous sommes au travail.
Plutôt que des aventures personnelles, nous faisons des propositions concrètes pour dessiner un horizon souhaitable.
www.leparisien.fr/elections/pr...
Thatβs completely crazy ! And worrisome β¦
Still waiting to see most UK and French universities to do the same β¦
Our brains are very similar at 4am!
Overview of the LEMUR steps: (1) subspace alignment, (2) differential expression, (3) DE neighborhoods, (4) pseudobulking.
After 4y in the making, I am super excited that my main PhD project is published ππ₯³πππ₯³
www.nature.com/articles/s41...
LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space.
Some highlightsβ¬οΈ
π₯ chatomics! I regret not learning this well in collegeβand it changed how I approach bioinformatics today. Hereβs my story and why you should avoid my mistake. π§¬
Paper alert from the Duff Lab π¨π¨ My amazing colleagues showed that, in novel MAPTKI models, hyperphosphorylation (in absence of aggregation or even seeding) is sufficient to drive synapse loss and cognitive deficits. Huge implications for preclinical research and the way to therapies. Have a read!!
Congratulations all! Looks great!
Mindblowing paper creating spatial aging clocks π€―π€― ! Very neat use of spatial tx. Congrats to @brunetlab.bsky.social and all the authors
Thank you so much ππ»πππ and well noted about the neurostar forum
Unfortunately so common β¦ but at least you got an answer!!
