@vgti
VGTI provides lifesaving solutions through transformative biomedical discovery and research, enabling the prevention and cure of global infectious diseases. www.ohsu.edu/vaccine-gene-therapy-institute
In their new publication our Caposio, Frueh, and Hancock lab teams with their contributors, establish Notch pathway suppression as a critical viral strategy for reactivation and highlight potential therapeutic targets for preventing HCMV disease.
Read more at:
pubmed.ncbi.nlm.nih.gov/41660859/
Amazing work by our Okoye, Hansen, Estes, Axthelm, Picker lab teams with their contributors, on their new publication investigating treatments using barcoded SIVmac239 in rhesus macaques!
Read more about SIV by visiting:
pubmed.ncbi.nlm.nih.gov/41617893/
Congratulations to our Okoye, Estes, Axthelm, and Picker Lab teams with their contributors on their new publication which investigates the magnitude and activation of SIV-specific CD8+ T cells.
Read more about SIV T Cell responses by visiting the below link.
pubmed.ncbi.nlm.nih.gov/41609736/
In this recently updated publication our Frueh, Streblow, and Hansen lab teams with their contributors, explore Human cytomegalovirus (HCMV) encoding and four viral Fc-gamma receptors (vFcΞ³Rs) that counteract antibody-mediated activation in vitro.
Read more at: pubmed.ncbi.nlm.nih.gov/39885150/
In their new publication, our Sacha affiliate lab with their contributors, explore the association with ccf-mtDNA dynamics in acute and chronic HIV infections.
Read more at: pubmed.ncbi.nlm.nih.gov/41556528/
In this review, our Hessell and Haigwood affiliate lab team with their contributors, address human monoclonal antibodies (mAbs) as a strategy for treating and preventing viral infections in pediatric populations.
Read the full article at: pubmed.ncbi.nlm.nih.gov/40174915/
Read the full article here:
pubmed.ncbi.nlm.nih.gov/41272845/
Our Bimber affiliate lab team with their contributors, recently published a paper where they seek to understand the degree and implications of intraspecies structural variation is essential to all biomedical research using rhesus macaques as a model.
...can be used to evaluate immune and viral determinants of protection against cCMV.
Read more at:
pubmed.ncbi.nlm.nih.gov/41286406/
In their newly published paper, our Frueh Lab with their contributors characterized the outcome of primary rhesus CMV (RhCMV) infection in pregnant, immunocompetent, RhCMV-naΓ―ve rhesus macaques. This model provides new insights into the complexity of CMV vertical transmission and...
In this study, our Picker and Hansen lab teams with their contributors, provide preliminary evidence that combining their selected orthogonal antiviral mechanisms can offer increased protection against SIV.
Read the full article here:
pubmed.ncbi.nlm.nih.gov/40529575/
In this publication, our Frueh Lab and their contributors, expand on their previous findings related to HLA-E surface expression. This updated study reveals previously unrecognized endosomal trafficking pathways and regulatory mechanisms that distinguish HLA-E from classical HLA class I molecules.
In their recent publication, our Streblow lab with their contributors, explore the emergence of mosquito-borne alphaviruses that cause chronic arthritis or encephalitis and highlight the urgent need for broad-spectrum antiviral therapeutics.
Read more at: pubmed.ncbi.nlm.nih.gov/41090377/
Leronlimab directly binds the extracellular domains of CCR5, modulates downstream signaling and potentially can slow, reverse, or prevent fibrosis. In this proofβofβconcept study, our Hansen Lab with contributors, demonstrated that leronlimab has a favorable safety profile and was well tolerated.
... and activate diverse host defenses.
Read more at:
pubmed.ncbi.nlm.nih.gov/41092897/
In this recent publication our Bimber, Hansen, Picker lab teams and their contributors demonstrate that systemic vaccination promotes a Trm cell response in barrier compartments and that Trm cells repurpose abundant neighboring stromal, parenchymal, and immune cells to amplify alarm signals...
Read the full article here:
pubmed.ncbi.nlm.nih.gov/41004538/
Liver dysfunction is more common and severe among people with HIV than in the general population. In this recent publication, our Burwitz affiliate lab explores the correlation between different cell types in the IFN-1 response, focusing on macrophage subsets during the acute phase of SIV infection.
...of the enzymes involved in their biosynthesis.
Read the full article here: pubmed.ncbi.nlm.nih.gov/40659247/
In their recent publication, our Tafesse affiliate lab with their contributors, explore SARS-CoV-2 and whether the patterns of host lipid rewiring remained consistent across variants and whether the changes in the abundance of lipid classes are related to changes in the expression...
...their potential antiviral activity, as typically prodrugs increase solubility and delivery. Additional studies are underway to elucidate the mechanism of action of these analogues.
Read the full article here: pubmed.ncbi.nlm.nih.gov/40939252/
In collaboration with Dr. Seley-Radtkeβs group at the University of Maryland, our Hirsch lab has contributed to a study identifying a new series of thiophene-expanded tricyclic nucleosides as potential antiviral therapeutics. In addition, their corresponding prodrugs were also pursued to probe...
In addition, MHC-E has a number of fascinating functions in regulating immunity that have many possible applications for the development of vaccines and immunotherapies against infectious diseases and cancer." -Klaus FrΓΌh, Ph.D.
Here is a link to the full text:
www.nature.com/articles/s41...
MHC-E is a non-classical MHC class I protein that has been studied for many years by the Oxford group and that we stumbled upon in our research on using cytomegalovirus as a novel vaccine vector. We found that T cells targeting MHC-E might be the key to the development of an AIDS vaccine
(continued)
"Everything you always wanted to know about MHC-E, but were afraid to ask.... is covered in this Nature Review, the result of a team effort together with Louis Picker here at OHSU and Andrew McMichael, Geraldine Gillespie and Persephone Borrow from University of Oxford.
(continued)
Read the full article here:
pubmed.ncbi.nlm.nih.gov/40862619/
Our Sacha Affiliate Lab, with their contributors, have recently published a new study where they explored the impact of obesity on the gut microbiome and microbial translocation (MT) biomarkers during HIV infection and antiretroviral therapy (ART). Amazing work done by all!
... facilitates the development of safe and efficacious vaccines in humans.
Read the full article here:
academic.oup.com/jimmunol/art...
