The Jeremy Chase Crawford Lab

Nineteen St. Jude scientists have been named to the 2025 Highly Cited Researchers list, the most from St. Jude since the list began. This distinction identifies those whose publications rank in the top 1% for citations, indicating broad influence. ow.ly/HKIk50XrffV

Super excited to present some of our newest work at @iuis-online.bsky.social #IUIS2025 in Vienna! Definitely the largest hall I’ve ever presented in.

The JCCLab is representing at #AAI2025!

Just saw a talk by Andrew Pask at #AGBT25 #AGBTGM on marsupial genomics, evolution, and gene editing for conservation. Completely mind blowing work. Taking both genetic editing and conservation work into a new frontier.

David Altshuler from Vertex kicking things off at #AGBT25 with an amazing talk but also an inspiring thought: “I hope that ‘hope’ is something that all of the work presented here can help create.” NIH-funded research is ultimately creating hope for the future, and we can’t forget that.

I guess I should clarify that I don’t think it’s just understanding the importance of job security (which I’m sure most do), but I’m lucky to be at a place that has also made a commitment to making it a priority in their everyday policies.

It’s beyond unfortunate that there is so much uncertainty in the job market for scientists, both in industry as well as academia. I’m INCREDIBLY fortunate to be at an institution that understands the importance of job security when trying to recruit talented team members.

St. Jude Is Hiring | Join Our Mission | St. Jude Careers Explore job opportunities at St. Jude Children’s Research Hospital. Career opportunities exist in the areas of science, clinical care, operations, and more!

The JCC Lab is #hiring experienced bench scientists for work on human immunology and assay development! These are long term, stable positions not subject to the ebb and flow of federal funding. talent.stjude.org/careers/jobs...

I have collected Christmas ornaments for years, but two of my close collaborators just gifted me my first JCC Lab ornament! They said it’s a rocket because “the lab is taking off”. Thanks so much @asya-minervina.bsky.social and Misha!

And great catching up with @habeljen.bsky.social and so many others!

Had a very productive and eventful time at @niaidnews.bsky.social for the annual meeting on the impact of initial influenza exposure on infant immunity. #immunology #development @eksliger.bsky.social @pgtimmune.bsky.social

Great interview of Sydney Brenner. One of my favorite stories of Crick and Brenner is their reaction to being scooped by Marshall Nirenberg in deciphering the genetic code. They were thrilled 🧪

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.

Super cool work with wide-ranging implications!

India's 'blockbuster' drugs to combat antibiotic-resistant superbugs A number of promising new drugs from India show potential to fight antibiotic-resistant bacteria.

very impressed by so many of India’s doctors and scientists stepping up to organize, innovate, and strategically confront the challenge of AMR that threatens their populous country and the world beyond
🇮🇳 🧫 🦠 💊 🇮🇳

www.bbc.com/news/article...

Great visit with an amazing talk and lovely dinner with @cobey.bsky.social today! And great company from @pgtimmune.bsky.social @rajerer.bsky.social ! Brilliant!

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, pr...

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation
doi.org/10.1101/2024...

The Engagement Is Better on Bluesky - Bluesky Bluesky is the lobby to the open web. Find and build your community here.

We could go on about how we welcome publishers, we don't demote links, we encourage independent developers to build apps and extensions on top of Bluesky's network.... but instead, we'll show you.

All thanks to the incredible community here! 🦋

How does antiviral #immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

A panoramic view of cell population dynamics in mammalian aging www.science.org/doi/10.1126/...

Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1 Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for i

Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

New publication by @aelewaut.bsky.social & @guillemxtivill.bsky.social from @obenaufa.bsky.social lab about cancer-mediated immune evasion – very interesting!

#HemeSky #OncoSky

www.nature.com/articles/s41...

Please add me! Thanks b

Hi all! I've created a started pack for academic professional development. Looking to build a community of folks supporting researchers, scholars, and educators (broadly defined) by sharing skills, tools, and resources. Please share and reply to nominate yourself or others!

go.bsky.app/vGDioH

a baby rhino is playing with snow in a zoo enclosure . Alt: a baby rhino is playing with snow in a zoo enclosure .

Talking of Bier, @orthopodreg.bsky.social the story of how he developed spinal anaesthesia is pretty wild

A story of cocaine, cigars, and German army helmets. #AnSky #MedSky #HistoryMedSky

Hi everyone!
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉

To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...

And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...

How well do vaccines protect vs #LongCovid, a systematic review during the Omicron era?
—about 20% reduced by primary series (vs no vaccination), and
—another 20% reduction by boosters vs primary series
www.medrxiv.org/content/10.1...

Who did I miss? Excited to get more SJ folks on the platform. go.bsky.app/Lv6kNiq

I think we need to create a CAR-T starter pack!

St. Jude Is Hiring | Join Our Mission | St. Jude Careers Explore job opportunities at St. Jude Children’s Research Hospital. Career opportunities exist in the areas of science, clinical care, operations, and more!

Do you know an experienced immunologist who is interested in studying human #immune development with next-generation methods? My lab is #hiring! Great pay, job stability, and a great place to work! Please share widely talent.stjude.org/careers/jobs...