Duncan Brownsey

Very happy to share that our Pd-catalyzed method for the functionalization of cyclopropenes is now available to read in @chemicalscience.rsc.org !

Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents Affinity-driven reactions have allowed chemists to perform site-selective modifications of native proteins. By combining the high cysteine chemoselectivity of hypervalent iodine-based ethynylbenziodox...

We just achieved the first site-selective cysteine functionalization with EBX reagents! @jacs.acspublications.org

pubs.acs.org/doi/10.1021/...

The preprint of the work of Josh Wu, Tobias Milzarek and Matthew Wodrich on the trifluoromethylation of Cyclopropenylbenziodoxoles is now available at ChemRxiv. This method gives access to unique fluorinated building blocks.

chemrxiv.org/engage/chemr...

From now on until end of September we consider applications to @lcsolab.bsky.social for a regular PhD position starting earliest in September 2026!

For general information, see:

www.epfl.ch/labs/lcso/gr...

For details on the application process, see:

www.epfl.ch/labs/lcso/wp...