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Archana Dhasarathy

@adhasarathy

Chromatin, TFs, epigenetic memory, and Epithelial- mesenchymal cell state transitions. Also will post about dogs/ cats/ animals/ nature.

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18.10.2023
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Latest posts by Archana Dhasarathy @adhasarathy

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🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

04.03.2026 16:08 πŸ‘ 94 πŸ” 36 πŸ’¬ 8 πŸ“Œ 7
a headshot of David Botstein

a headshot of David Botstein

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

02.03.2026 15:39 πŸ‘ 52 πŸ” 29 πŸ’¬ 0 πŸ“Œ 2

I feel your pain. I once got an 8 page answer for something that could have been answered in 1-2 sentences. (I even said, β€œanswer in no more than 2 sentences β€œ). Le sigh.

23.02.2026 21:07 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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11.02.2026 12:18 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Afting, C., Walther, T., Drozdowski, O. M., Schlagheck, C., Schwarz, U. S., Wittbrodt, J., & GΓΆpfrich, K. (2024). DNA microbeads for spatio-temporally controlled morphogen release within organoids. Nature Nanotechnology www.nature.com/articles/s41... #EpithelialMechanics

10.02.2026 08:00 πŸ‘ 10 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Look at this πŸ™‚ #CryoEM

Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org

www.biorxiv.org/content/10.6...

09.02.2026 08:32 πŸ‘ 75 πŸ” 18 πŸ’¬ 4 πŸ“Œ 0

I was just thinking this!! Retat !!

05.02.2026 22:47 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Unique territorial and compartmental organization of chromosomes in the holocentric silkworm - The EMBO Journal Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in ...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded β€œS” compartment
link.springer.com/article/10.1...

03.02.2026 10:37 πŸ‘ 38 πŸ” 25 πŸ’¬ 0 πŸ“Œ 2

If you are a student whose NSF GRFP application was returned without review for vague 'eligibility' reasons:
1) Let your department chair & Graduate School know. Encourage them to contact NSF & congress
2) Write to your congressional reps.
3) Write to grfp@nsf.gov to request re-consideration;

30.01.2026 17:15 πŸ‘ 95 πŸ” 83 πŸ’¬ 7 πŸ“Œ 0

Cool thread with examples of the role of cell junctions in collective cell migration! πŸ§ͺ

31.01.2026 14:08 πŸ‘ 20 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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Vector was my cat.

30.01.2026 02:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
Bruce Springsteen - Streets Of Minneapolis (Official Audio) YouTube video by Bruce Springsteen

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

28.01.2026 17:02 πŸ‘ 97508 πŸ” 40896 πŸ’¬ 4302 πŸ“Œ 5366
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One of the best things I’ve read in a while:

25.01.2026 22:39 πŸ‘ 28793 πŸ” 10724 πŸ’¬ 42 πŸ“Œ 981

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.

White. Hot. Rage.

24.01.2026 19:31 πŸ‘ 60632 πŸ” 18877 πŸ’¬ 1404 πŸ“Œ 741
A serene forest stream flowing over moss-covered rocks with text inviting applications for Co-Editor-in-Chief at FACETS.

A serene forest stream flowing over moss-covered rocks with text inviting applications for Co-Editor-in-Chief at FACETS.

FACETS Journal is looking for a Co-Editor-in-Chief to curate content, support diverse voices in research, and collaborate with our editorial team. Expertise in ecology, conservation biology, biodiversity, or environmental sciences is ideal.


Learn more ▢️ https://ow.ly/Gbzv50Xo3Ks

23.01.2026 13:45 πŸ‘ 0 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Thank you so much for the great talk and wonderful science conversations! @takakulab.bsky.social and our students and other faculty really appreciated your sharing your science with us!

22.01.2026 16:25 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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πŸ₯ #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026!
πŸ“‹Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...

21.01.2026 10:48 πŸ‘ 20 πŸ” 13 πŸ’¬ 0 πŸ“Œ 4
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Tom Cech to Davos: RNA research is 'still a big deal' The Nobel laureate and CU Boulder professor, recently ranked #1 globally for RNA research, will speak at the World Economic Forum annual meeting in Davos,

www.colorado.edu/today/2026/0...

21.01.2026 03:15 πŸ‘ 21 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.

This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.

www.nature.com/immersive/d4...

20.01.2026 22:53 πŸ‘ 14450 πŸ” 8316 πŸ’¬ 90 πŸ“Œ 765
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Antisense transcription can induce expression memory via stable promoter repression - Genome Biology Background The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mu...

⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out!
βž‘οΈβ¬…οΈ They dissect how memory can arise from antisense transcription using mathematical modelling πŸ’», genomics 🧬 and synthetic biology βš’οΈ! link.springer.com/article/10.1...

20.01.2026 11:02 πŸ‘ 55 πŸ” 23 πŸ’¬ 1 πŸ“Œ 0
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Loved this from @simonmaechling.bsky.social - chemistry FTW…
@dereklowe.bsky.social @carolynbertozzi.bskyverified.social

19.01.2026 14:08 πŸ‘ 95 πŸ” 24 πŸ’¬ 1 πŸ“Œ 3
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Rubbish years: how to boost lab group morale when world events crash in Award-winning mentors share best practice to keep your team going amid political upheavals, economic downturns and other events.

I wrote about this for Nature last July - good advice here from some award-winning academic mentors around the world: www.nature.com/articles/d41...

18.01.2026 02:05 πŸ‘ 28 πŸ” 9 πŸ’¬ 3 πŸ“Œ 1
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Some joy in this crazy world.

15.01.2026 16:55 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Janssen, V., & Huveneers, S. (2024). Cell–cell junctions in focus–imaging junctional architectures and dynamics at high resolution. Journal of Cell Science, #EpithelialMechanicsReview doi.org/10.1242/jcs....

02.01.2026 08:00 πŸ‘ 21 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0
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Activator-promoter compatibility in mammals: a CpG-Island-specific co-activator directly bridges transcription factors to TFIID Transcription from CpG island (CGI) promoters controls the expression of two-thirds of mammalian genes, yet despite their prevalence, it remains unknown whether CGI-specific co-activators with intrins...

Read the full story in our preprint! πŸ‘‡
biorxiv.org/content/10.6...
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the
@alex-stark.bsky.social and @plaschkalab.bsky.social labs! 🀝πŸ§ͺ

29.12.2025 19:30 πŸ‘ 16 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Robert F. Kennedy Jr. has stated that the 1918 flu pandemic was caused by a lab virus from vaccine research, a defective influenza vaccine. Let’s analyze what a lie this is. First, in 1918, 107 years ago, virology was in its infancy

27.12.2025 23:42 πŸ‘ 7873 πŸ” 2743 πŸ’¬ 206 πŸ“Œ 368
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken

Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken

Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/

26.12.2025 21:15 πŸ‘ 4533 πŸ” 729 πŸ’¬ 41 πŸ“Œ 47

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

25.12.2025 06:33 πŸ‘ 212 πŸ” 78 πŸ’¬ 5 πŸ“Œ 9

Walking around the #NIH hospital and seeing all kinds of patients getting care here: kids in wheelchairs, adults in masks and chemo caps.

And all of this is being cut down, undermined, and destroyed by Trump. It should make us all incredibly angry.

17.12.2025 20:03 πŸ‘ 94 πŸ” 26 πŸ’¬ 0 πŸ“Œ 2