Pedro Pimentel-Coelho

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

Treating fetuses with stem cells proves safe in milestone spina bifida trial The study is now scaling up to do more in utero procedures and evaluate effects on disability as children grow

Honored to be part of this trial, led by my amazing colleague Dr. Farmer, with much teamwork. Thank you for funding from @cirmnews.bsky.social (CIRM). 🫶
Treating fetuses with stem cells proves safe in milestone spina bifida trial | Science | AAAS www.science.org/content/arti...

IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness During sickness, animals exhibit prolonged social withdrawal, a response that may limit disease spread. Elevated IL-1β levels during inflammation activate IL-1R1-expressing neurons in the dorsal raphe...

IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness

Liu Yang et al.

www.cell.com/cell/abstrac...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Ironing out mechanisms of ferroptotic death to tailor new stroke therapies

Geena FM Capps et al. 🧪

journals.sagepub.com/doi/10.1177/...

Autoantibodies as drivers of neuropathic pain Emerging evidence, supported by clinical responses to immunotherapy and the recapitulation of sensory symptoms in passive transfer models, shows that autoantibodies (AAbs) may drive neuropathic pain. ...

Autoantibodies as drivers of neuropathic pain

Adham Farah et al. 🧪

www.cell.com/trends/molec...

Recommendations for the inclusion and study of sex and gender in research - Nature Neuroscience In this Perspective, the international PAINDIFF Network makes 13 recommendations for studying sex and gender as variables in preclinical, clinical and translational pain research that are applicable a...

Recommendations for the inclusion and study of sex and gender in research

David P. Finn et al. 🧪

www.nature.com/articles/s41...

The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation - Nature Immunology Qian and colleagues show that IL-17REL functions as a decoy receptor to suppress the effects of IL-17 family cytokines and reduce intestinal inflammation.

The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation

Qi Li et al. 🧪

www.nature.com/articles/s41...

Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface Petry et al. demonstrate a defined migration route of microglia progenitors from the surrounding mesenchyme into the embryonic CNS. This process relies on integrin activation and interactions with the...

Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface

Philippe Petry et al. 🧪

www.cell.com/developmenta...

Briefing Chat: What Brazilian centenarians could reveal about the science of ageing Hear the biggest stories from the world of science | 30 January 2026

Nature Podcast 🔊 the team discuss the week's top science news, including what Brazilian centenarians could reveal about the science of ageing

go.nature.com/4qQmWSD

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Monocyte-derived macrophages and their roles in ischemic stroke

Connor Dufort et al.

journals.sagepub.com/doi/10.1177/...

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease Microglia—the parenchymal tissue-resident macrophages of the brain and spinal cord—are essential to support brain health by integrating environmental cues and performing immune functions and reparativ...

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease

Jordan E. McKinney, Mariko L. Bennett, and F. Chris Bennett

www.annualreviews.org/content/jour...

Ischemic stroke and comorbidities: Impact on recovery and the role of genetics and epigenetics Ischemic stroke (IS) remains a leading cause of long-term disability and mortality worldwide, with recovery outcomes shaped by the interplay between a…

Ischemic stroke and comorbidities: Impact on recovery and the role of genetics and epigenetics

Andreea Cercel et al. 🧪

www.sciencedirect.com/science/arti...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease

João Pedro Ferrari-Souza et al.

www.nature.com/articles/s41...

Neuroimmune dynamics and cytokines in traumatic brain injury Traumatic brain injury (TBI) is a leading cause of neurological disability, associated with higher rates of cognitive complications that negatively affect recovery. Myriad cytokine and chemokine pathw...

Neuroimmune dynamics and cytokines in traumatic brain injury

Amara C. Davis & Jonathan P. Godbout

www.cell.com/trends/immun...

Intranasal therapies for neonatal hypoxic-ischemic encephalopathy

Cavanagh et al.

journals.lww.com/nrronline/ab...

Acute ischaemic stroke alters the composition and function of circulating B cells Distinct B cell populations are found in circulation, including those with innate-like properties, that have varied functions in pathogen protection, …

Acute ischaemic stroke alters the composition and function of circulating B cells

Mehwish Younas et al. 🧪

@brainbehavimm.bsky.social

www.sciencedirect.com/science/arti...

Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study - Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Cr... Cognitive decline is a significant long-term consequence of stroke with no available treatments. To aid in therapy development, we sought to achieve robust dete...

Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study

Gaia Brezzo et al.

journals.sagepub.com/doi/full/10....

A 75-year-old man with hypertension was brought to the emergency department after a motor vehicle collision. A video recording from the dashboard camera in his car showed a loss of ability to react to events on his left side. Read the full case details: nej.md/48GkW8U  

#MedSky #NeuroSky

The duality of the BBB: breaking the myth of the blood-brain barrier breakdown - Fluids and Barriers of the CNS Fluids and Barriers of the CNS - Research on the blood-brain barrier (BBB) has greatly evolved over the past 20 years, with growing recognition of its role as a multicellular complex regulating...

The duality of the BBB: breaking the myth of the blood-brain barrier breakdown

Frédéric Calon

link.springer.com/article/10.1...

Happy to see Dr. Raquel Campos, a wonderful postdoc in our group, highly commended in the Lab Heroes Awards 2025!

Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy | PNAS Autoantibodies contribute to many autoimmune diseases, yet there is no approved therapy to neutralize them selectively. A popular mouse model, expe...

Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy

Reza Taghipour-Mirakmahaleh et al.

www.pnas.org/doi/10.1073/...

Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet AbstractAims. High dietary salt intake has powerful effects on cerebral blood vessels and has emerged as a risk factor for stroke and cognitive impairment.

Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet

Sung-Ji Ahn et al.

academic.oup.com/cardiovascre...

Evolving insights into the identity and function of dark microglia Microglia are the brain's primary innate immune cells, which maintain neural homeostasis through surveillance, debris clearance, and synaptic remodeling. Dark microglia represent a distinct state of m...

Evolving insights into the identity and function of dark microglia

Anna Flury et al.

www.cell.com/trends/neuro...

Thanks!!!

Any recommendations for a rat anti-mouse NeuN antibody?

This scientist is breeding billions of mosquitoes to fight disease in Brazil Luciano Moreira is part of Nature’s 10, a list of people who shaped science in 2025.

"This scientist is breeding billions of mosquitoes to fight disease in Brazil

Luciano Moreira is part of Nature’s 10, a list of people who shaped science in 2025."

By Mariana Lenharo

www.nature.com/articles/d41...

Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀
Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!

Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers Click on the article title to read more.

Obituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers

Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla

onlinelibrary.wiley.com/doi/10.1002/...

Branched actin networks mediate macrophage-dependent host-microbiota homeostasis Branched actin networks formed by the Arp2/3 complex are essential for immune system function. Patients with loss-of-function mutations in the ARPC5 subunit of the Arp2/3 complex develop inflammation ...

Branched actin networks mediate macrophage-dependent host-microbiota homeostasis

Luiz Ricardo C. Vasconcellos et al.

www.science.org/doi/10.1126/...

Delayed adoptive transfer of bone marrow-derived macrophages modulates post-ischemic inflammation in a model of neonatal hypoxia-ischemia Neonatal hypoxic-ischemia (HI) represents a major cause of brain injury in the perinatal period. Post-ischemic neuroinflammation plays a key role in H…

Delayed adoptive transfer of bone marrow-derived macrophages modulates post-ischemic inflammation in a model of neonatal hypoxia-ischemia

Elena Di Martino et al.

www.sciencedirect.com/science/arti...