Our paper with @sokrypton.org using AlphaFold2 to predict small-molecule binding sites in proteins is now out in Nature Methods! 🧵
rdcu.be/e7SnX
www.nature.com/articles/s41...
Nice resource! Thanks for making it open access. Check your protein friends people ( and the accompanying paper in Nat. Methods). 🤩🧶🧬
1610 Marie Curie postdoctoral fellowship awarded out of 17066 applications.
Over 50,000 reviewers… Can you fathom the amount of work involved? And sadly the level of waste?
By 2028, all 4-character PDB IDs will be exhausted.
After that, all new entries will receive extended IDs: 12 characters total, formatted as pdb_ + 8 alphanumeric characters (pdb_1000axyz)
Test it from PDB Beta Archive
Read more: www.wwpdb.org/news/news?ye...
Penultimate talk of the meeting by Lauren Porter. Looking at how AlphaFold works under the hood with fold switching proteins.
First speaker. Last session at Lorne Proteins. Michael Hecht on designing proteins for novel functions @lorneproteins.bsky.social
Emily Furlong (UQ alumnus 😄) talking about her new work on ABC transporters. @emfurlong.bsky.social @lorneproteins.bsky.social
Closing Session 6: Simon Newstead - Animal to Atom: New avenues for targeting chronic pain.
Solute carrier signalling - signaling solute concentrations. Model 1 - e.g. No substrate, lumen ion conc changes. Transporter stabilises, permitting binding TASL, scaffolding its folding.
#lorneproteins2026
Closing Session 4 - Ben Corry - on Membrane transporter plasmodium falciparum Formate Nitrate transporter - moves lactate and protons out of the cell. Detoxification of glycolysis products.
Transporter or channel??
Central His highly conserved.
#lorneproteins2026
Closing Session 3: Elitza Tocheva - Inner to Outer membrane remodelling. Sporulation in Firmicutes cryoET of sporulation.
Asymmetric septum, engulfment, spore formation. Second outer spore membrane is lost during germination...
#lorneproteins2026
Fabien Munder - New strategies to fight AMR.
Bacterial competition via L-type pyocins; targeting (1) BamA EC loop 6, (2) beta-strand 1.
Inhibit beta barrel assembly by blocking the BAM barrel lumen. Increase cell permeability - holes in the OM. 👏
(EMReady post-processing) 🤓
#lorneproteins2026
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
Join us on campus & online on Monday, 16 Feb 2026 at 1pm for a seminar by Ciara Wallis, PhD Candidate @corrylab.bsky.social! Details: biology.anu.edu.au/news-events/....
Here’s @jsresearchpro.bsky.social reporting on ridiculous new ARC grant time-scales (e.g. 16 months for DPs).
The ARC “did not respond to questions about the reasons for the length of the delays or on how the changes will affect researchers’ planning”.
I reckon they haven’t thought that far ahead.
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
In 2024, researchers in #ScienceRobotics followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit.
Learn more: https://scim.ag/3LmQ9oL #ScienceMagArchives
Mind bogglingly awful. It shouldn’t take a year+ to find out if you have a grant. This is careers and lives being messed with.
Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...
🌟 New Tool Alert!
We present MemPrO – a toolkit for orienting and building membrane protein systems:
✅ Membrane protein orientation
✅ Mixed membrane building
✅ Double membranes & curvature
✅ Peptidoglycan cell wall support
🔗 github.com/pstansfeld/mempro
📖 pubs.acs.org/doi/10.1021/...
Lorne Proteins 2026 🏖️🤩 Featuring speakers Elitza Tocheva, UBC, on outer spore membrane biogenesis for endospore formation in Firmicutes; and EMBO keynote speaker David Drew, Stockholm University, focusing on GLUT glucose transporters and Na⁺/H⁺ exchangers.
🔗 Register now at: www.lorneproteins.org
🚨My lab is hiring a postdoc!🚨
If you’re interested in working out the mechanism and physiological impact of bacterial lipid transport processes then please apply!
Job advert is here: tinyurl.com/4swddfda
Get in touch by email (c.mulligan@kent.ac.uk) for informal enquiries
Please repost!
Thanks!
be the bitch doing something yourself that you want to see in the world
Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other.
Shared by @gizmodo.com: buff.ly/yAAHtHq
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
Screenshot of tweet from the ARC saying they’ll announce DECRA and LIEF outcomes on Tuesday 25th Nov.
ARC says they’ll announce DECRA and LIEF outcomes tomorrow (Tuesday 25th Nov).
In recent times these announcements have been around 11am Canberra time. With 2 schemes on the same day, I assume they’ll announce one of them later in the day (probably DECRA first).
"We thank the reviewers for their helpful suggestions"
Toxoplasma gondii carefully balances calcium between its organelles. This study shows the ER, via the SERCA pump, is central to controlling Ca²⁺ in the cytosol and mitochondria.
🔗 buff.ly/RFgcZgE
