Deutsche Gesellschaft für Neurogastroenterologie & Motilität

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health - Nature Reviews Gastroenterology & Hepatology This Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term i...

Excited to share our latest publication! 🎉
This consensus statement, led by @isappscience.bsky.social, establishes an evidence-based definition of gut health relevant to clinical practice & dietary & biotic interventions.
www.nature.com/articles/s41...
#GutHealth #Microbiome #ISAPP #DigestiveHealth

🧠🌐 DGNM-Jahrestagung 2026 – 3 Tage Vernetzung entlang der Darm-Hirn-Achse. Exzellente Wissenschaft, starke Nachwuchsbeteiligung und tolle Zusammenarbeit. Die NeuroGastro Community zeigt, wie gemeinsam durch Grundlagenforschung, Translation und Klinik Fortschritt entsteht. 🚀 #DGNM #GutBrainAxis

🦓 tomorrow is #RareDiseaseDay!

Last weekend already we presented our data on #ENS changes in #Gastroschisis and on the transition of #Hirschsprung disease patients at the annual meeting of the German #Neurogastro society @dgnm.bsky.social

#neuroscience #gastroenterology @simsooo.bsky.social

Abdominal ultrasound activates afferent vagal signaling and central autonomic pathways.

Abdominal ultrasound activates afferent vagal fibers and suppresses systemic inflammation.
This 🤯 paper has many interesting findings, including increased c-Fos expression in the NTS, confirming central activation. #neuroskyence 🩺
Work by Shimoyama et al., PNAS
www.pnas.org/doi/abs/10.1...

A sneak peak of a complex and technically challenging experiment that my lab developed: doi.org/10.1096/fj.2.... Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple 1/3

The gut microbiome puzzle and probiotics in primary care patients with IBS Gut microbiome-related interventions for the management of disorders of gut-brain interaction were on the agenda of NeuroGASTRO 2025. In this video interview, Dr. Juan M. Mendive delves into the role of the gut microbiome for improving outcomes of primary care patients with IBS.

Disorders of gut-brain interaction are frequently encountered in primary care.
Dr. Juan M. Mendive explores the role of the gut microbiome and probiotics in improving outcomes for patients with #IBS—and what this means for everyday clinical practice. 

Watch the interview 👇

📢 Just a few days left until our annual meeting in Freising

🫵 join in last minute to get the latest updates on #enteric #neuroscience, translational and clinical #neurogastroenterology!

Find everything you need to know on our website 👇

www.neurogastro.de/de/jahrestag...

#neurogastro #motility

The balance of fiber and protein intake has been largely overlooked

This timely review in @natrevgastrohep.nature.com updates factors that influence human digestion and absorption of protein in the small intestine and protein fermentation in the colon:

https://tinyurl.com/4ebkb6js

⏳ One month to go until #GMFH2026!

Join us in Porto, March 14–15, to explore the latest advances in diet & microbiome modulation in clinical practice.
👉 Register now and secure your spot
https://www.gutmicrobiotaforhealth.com/porto-2026-fourteenth-edition/registration/

😊 We welcome you to the next Immune Alliance Seminar on Feb 18, 2026, 9 am (in Germany) / 5 pm (in Japan), via zoom. You are cordially invited to attend. Registration is free. Register via: dgfi.org/immune-allia...

@zielinskilab.bsky.social @efis-immunology.bsky.social @iuis-online.bsky.social

Laboratoriummanager TARGID zoekt een enthousiaste laboratoriumtechnoloog.

We're hiring! 🧪
TARGID @ KU Leuven is looking for a Laboratory Manager to coordinate and support cutting-edge research on gastrointestinal diseases.
📍Leuven | ⏰ Apply by Nov 4, 2025
🔗 kuleuven.be/personeel/jobsite/jobs/60566238
#KULeuven #Hiring #Research

😱 The Belgian Week of #gastroenterology is currently rocking Antwerp!
🔬 listened to great #science
🫂 met new and old friends
🗣 one keynote from the lab on #ENS progenitor cells and aging

Thanks for hosting, Werend Boesmans!
#neurogastro

🧠 Study examines implications of shame for patient-reported outcomes in bowel disorders of gut-brain interaction
🔗 https://ow.ly/ojnb50Y7HTo

APC is recruiting a Postdoc to work with @lilykeane.bsky.social at UCC on a project focusing on how early-life microbiome perturbations shape brainstem microglial development during the neonatal period.
#microbiome #glioma #cancer #jobfairy #researchjobs #ucc
Full Details: bit.ly/4tlQjxO

⏰Final Call!! Three days left to apply for #LBBB2026
Don't miss out on your opportunity to attend the best early career meeting in the #neurogastroenterology field.
www.lbbb2026.com/apply
@dgnm.bsky.social @gastronauts.bsky.social

In Tübingen ging es dann 2017 im brandneuen @neuromadlab.bsky.social mit Nils Kroemer ganz tief in die Materie. Thematisch drehte sich alles um die Darm-Hirn-Achse und wie die metabolischen Signale, die der Vagusnerv weiterleitet, den Körper im Gleichgewicht halten.

Looking back on 2025, inspired by the Year in Reviews starting on p112.

Our February ISSUE is live! Year in Review 2025, gut virome, gut-brain axis, liver-brain axis, cancer registries in Africa, and much more!

www.nature.com/nrgastro/vol...

⏩#GLP1 #Serotonin, the body’s multitasking maestro #DGBIs💡 🎯A blueprint for developing #orally active small-molecule secretagogues capable of activating the body’s own incretin sensors & gut-brain axis👏 📢The advent of GLP-1–based therapies has reshaped modern metabolic medicine, providing unprecedented efficacy in treating diabetes and obesity. Yet, these advances rely heavily on injectable hormone mimetics #semaglutide #tirzepatide 🎯Transform EC and L cells into tunable therapeutic switches—enabling mechanism-based, physiological treatments for diabetes, obesity, and disorders of gut–brain communication‼️ 🎯Through #neuropod synapses, EECs transmit real-time information about nutrient composition to the brain—forming a crucial component of #interoception, the body’s sense of internal state 🎯A detailed map of human enteroendocrine cell function & receptor signaling—laying the foundation for oral therapies that stimulate endogenous hormone secretion🌟 ⏩Description and functional validation of human enteroendocrine cell sensors @ScienceMagazine👏 👉 https://www.science.org/doi/10.1126/science.adl1460

Dive deep into our latest #GastroDigest @aga-gastro.bsky.social 🆕🔥
🚨Turning #GutSensors into Therapeutic Switches: A #Sensorome Roadmap for Metabolic & Gut–Brain🧠Interaction Disorders‼️ @amergastroassn.bsky.social 🙌
Prof. Kara Margolis🙏😇
👉 www.gastrojournal.org/article/S001...
#DGBI #GLP1 #Serotonin

A neurobiotic sense curbs feeding: a new frontier in gut–brain communication Nature Reviews Gastroenterology & Hepatology, Published online: 02 October 2025; doi:10.1038/s41575-025-01126-zIn a new study by Liu and colleagues, researchers demonstrated a novel neuroepithelial circuit in colonic neuropod cells through which a molecular pattern from resident microorganisms was relayed to the brain — a ‘neurobiotic sense’ by which the host adjusted its feeding behaviour by monitoring a gut microbial pattern.

ICYMI: New online! A neurobiotic sense curbs feeding: a new frontier in gut–brain communication

➡️ This #narrativereview provides an overview of functional dysphagia and details our unique multidisciplinary approach to these patients from the perspective of GI, speech-language pathologists, and GI psychologists at the USF Swallowing Center
🔗 https://ow.ly/uaVv50Y8rKU

KEY POINTS • Enterochromaffin (EC) cells release signaling molecules which can activate nearby sensory nerves.Whether this occurs via a conventional synapse for-mation is unknown. • EC cells rarely make contact with sensory nerves inthe upper gut but this frequency increases in the distal colon. • Neurite-like protrusiton on EC cells, named by some as “neuropods” are not a preferential site of contact with nerve fibres.

🆕 #Neuroepithelial landscape of #Enterochromaffin cells varies across #GI location‼️
✅EC cells rarely make contact with sensory nerves in upper gut but this frequency increases in distal colon👏
🎯 #Neuropods are not a preferential site of contact🔥
👉 onlinelibrary.wiley.com/doi/10.1111/...
#ANMS #ESNM

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...

📢Good news! If you need a little bit more time to apply for LBBB2026, we have you've got you covered!
New (and very final) deadline to apply is
🗓️9th Feb 2026
Don't leave it to the last minute and join us in Fusagasuga 🔗https://www.lbbb2026.com/apply

Die Woche neigt sich langsam dem Ende zu und ich möchte mit euch über etwas sprechen: das Bauchgefühl. Viele von euch kennen es wahrscheinlich, z. B. „Schmetterlinge im Bauch“, „Liebe geht durch den Magen“ oder „das Herz sinkt in die Hose“. Diese Phänome sind das Ergebnis der Darm-Hirn-Achse. 1/6

The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events Gut-brain vagal signals gate dopamine ensembles, reshaping reward and motivation beyond a brain-centric view.

"These findings challenge the traditional brain-centric view of reward processing, supporting a more integrated model in which vagus-mediated interoceptive signals intrinsically shape motivation and reinforcement."
Awesome work by @peppeganga.bsky.social & his team 👏
www.science.org/doi/10.1126/...

New APC paper in Nature Communications.

First author Tatiana Borodovich and colleagues examine how capsids drive large-scale DNA transfer in the gut. The study forms part of the research programme of Prof. Andrey Shkoporov's group at APC.
www.nature.com/articles/s41...
#Bacteriophage #Microbiome

https://www.lbbb2026.com/apply

📢REMINDER: The deadline to apply for LBBB2026 is Monday (2nd February)
📍The meeting takes place in Fusagasuga (Colombia) 31st October - 4th November
📬Apply Now to be part of a small meeting with big ideas
@dgnm.bsky.social

Parkinson’s may originate in the enteric nervous system, via muscularis macrophages containing misfolded α-synuclein that develop endolysosomal dysfunction & promote T cell expand/traffic to brain
www.nature.com/articles/s41... @nature.com @soyonhonglab.bsky.social @ucl.ac.uk @cmn-vib.bsky.social

The Impact of Cannabis Use in Gastroparesis: A Propensity-Matched Analysis of 41,374 Gastroparesis Patients
Kilani, et al.

📕 doi.org/10.14309/ajg.0000000000003479

Commensal fungus to the rescue of gut injury - Nature Microbiology A mouse commensal fungus, Kazachstania pintolopesii, secretes a protein, Ygp1, that promotes epithelial cell regeneration and healing in mouse models of intestinal injury, renewing the interest in pro...

Nice summary of a paper that revealed a healing role for a fungi that is part of the gut commensal microbiome 🧵🧪#MicroSky