Michelle Linterman

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, a...

Our workflow to image and analyse germinal centres using a 50-plex cyclic staining protocol now out. Work led by Isabel San Martín Molina & Edith Marcial Juárez with @babrahaminst.bsky.social imaging facility scientists Simon Walker & Hanneke Okkenhaug.
onlinelibrary.wiley.com/doi/10.1002/...

It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details.
Don't miss out, register now! www.lorneinfectionimmunity.org/registration
#lorneiandi

Thank you Ola!

Thank you Alex! Credit to Louise Webb for leading this project.

Thank you Zia! Credit to Louise Webb who led the work.

Transient disruption of T cell help impairs germinal center dynamics and memory responses Germinal center responses can recover from transient loss of T cell help, but the sustained reduction in TFH cells impairs recall responses.

Work led by Louise Webb now out www.science.org/doi/10.1126/...

A huge team effort: Helena Carslaw, Jess James,
@emae-watson.bsky.social, Silvia Innocentin, Jayalini Assalaarachchi, Sigrid Fra-Bido, Isabel San Martín Molina, @smguillaume.bsky.social , Sam Woolliscroft, Alice Burton & Grant Kennedy

However, Tfh cells did not come back in full numbers, which left a hole in the memory T cell pool, resulting in smaller recall germinal centres upon rechallenge.

The GCs contracted, because of the lack of Tfh cells to support ongoing B cell proliferation, but then recovered when Tfh cells repopulated the GC. Resulting normal output and affinity maturation.

We did. We wanted to disentangle the role of Tfh cells in GC formation from their ongoing maintenance, so we used a Il21cre iDTR approach to delete Tfh cells from established GCs. Our hypothesis was that the GC would collapse, but it was surprisingly resilient.

Ever wondered what happens if you remove Tfh cells from established germinal centres?

Thanks for highlighting our work 🙏
Project led by Louise Webb @babrahaminst.bsky.social

Thank you Fiamma. So good to be at LUMC and the NVVI this week. Great science, and great company!

Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social

Flyer for Keystone meeting on Stromal immunology in health and disease, Feb 2-5th 2026.

Save the date! Keystone Stromal Immunology meeting, Feb 2-5, 2026 #KSStromal26
1. Scholarships/Short Talk Abstracts: October 7
2. Early Registration: December 3 (Save $200!)
3. Poster Abstracts: January 12, 2026 (11:59 MST)
Please share! And reach out if you have any questions.
Can't wait!

It was so good! Disappeared very fast.

It was great to be back at the @babrahaminst.bsky.social this week to spend time with the team talking about our science, and even managed a (very well timed) paper celebration! Amazing Tfh/GC themed brownie from Jess James.

Thank you @immunologyking.bsky.social & @maurogaya.bsky.social for organising the #EMBObarrierTissues meeting in Basel this week. Great science, great people, great atmosphere ❤️

Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes Natural intraepithelial T lymphocytes (T-IELs) are innate-like, intestine-resident T cells essential for gut homeostasis. These cells express self-reactive T cell antigen receptors (TCRs) due to thymi...

Beautiful talk from @mahimaswamy.bsky.social at #EMBObarrierTissues. Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes | bioRxiv share.google/UroEHTZJI7tk...

Fantastic @embo.org young investigator lecture on lung B cell responses from @maurogaya.bsky.social #EMBObarrierTissues

Likewise!

Lovely to meet you, Line, and to discuss the importance of sex in vaccine responses ❤️

Thank you Cris 🙏
Credit to Alyssa Silva Cayetano and Theresa Pankhurst for leading these research projects

Absolutely fantastic to have @labliston.bsky.social visiting the @malaghan.bsky.social this week. Beautiful talk on harnessing the power of Tregs to promote tissue repair, as well as many scientific discussions, an award ceremony at @nzparliament.bsky.social and multiple runs up our hills!

A pleasure to have you in Aotearoa New Zealand to celebrate science!

Fantastic to have Johanne Jacobsen at @malaghan.bsky.social this week presenting her beautiful work on germinal centre T cells, in all their complexity.

Finally, after moving halfway across the world to beautiful Aotearoa New Zealand, our (Italian) espresso machine has arrived. Even better that we can get tasty beans from Acme who also make a special @malaghan.bsky.social blend that supports our research ❤️ lnkd.in/gbWi6RuW

Not in our contribution, simply because it's not our area of expertise. But it's a really important topic.

Aging's impact on the immune system Description This 2025 collection of The Journal of Immunology features a special collection of articles curated by guest editor Patricia Gearhart. The collecti

Great to have the @jimmunol.bsky.social special collection, “Aging's impact on the immune system” out. academic.oup.com/jimmunol/pag...

Thanks for highlighting our work 🙏 Credit to @wsfoster.bsky.social and Edith Marcial Juárez for leading on this.