André C. Müller Chengzhe Tian Abigail Jarret Julio Garcia Daniela Reil Diana Santacruz Mary Piotrowski Stephen Noell Christoph Bueschl Huanyu Li @Smereiter Tiago Oliveira Josef (Joe!) M. Penninger @penningerlab.bsky.social @davidbsauer.bsky.social Claire M. Steppan Coralie Viollet Kristap Klavins

@rebsamenlab.bsky.social‬ Sabrina Lindinger Iciar Serrano Christoph Klimek Barbara Barbosa Anastasiia Pantielieieva @vojtechdvorak.bsky.social J. Thomas Hannich Julian Schoenbett Gilles Sansig Tamara A.M. Mocking Jasper F. Ooms Adriaan P. IJzerman Laura Heitman Peter Sykacek Juergen Reinhardt

Mariah Kohlbrenner Lena Chang Paul Selzer Jürgen Reinhardt Daniela Digles @gerhardecker.bsky.social Tanja Osthushenrich Aidan MacNamara @j-anders.bsky.social David Hepworth Svenja Onstein Enrico Girardi Rene Ladurner Eva Lineiro-Retes Zuzana Gelova Brianda L Santini @annkatrinhopp.bsky.social

Thank you to the authors: Ulrich Goldmann Tabea Wiedmer Andrea Garofoli Vitaly Sedlyarov Manuel Bichler @gernot-wolf.bsky.social Eirini Christodoulaki Alvaro Ingles Prieto Evandro Ferrada @fabianfrommelt.bsky.social Shao Teoh Thing @pleippe.bsky.social Ben Haladik Gabriel Onea Martin Pfeifer

Thank you to all partners, including @cemm-vienna.bsky.social @meduniwien.ac.at @oeaw.bsky.social @novartis.bsky.social‬ @univie.ac.at e.ac.at‬ Bayer Pfizer @boehringerglobal.bsky.social @cmd.ox.ac.uk @ndm.ox.ac.uk

RESOLUTE Research Empowerment on Solute Carriers

All reagents, tools, and datasets from the RESOLUTE project are openly available at re-solute.eu, promoting open science and facilitating research efforts on #TransporterProteins worldwide. Funded by @ihieurope.bsky.social, the EU, EFPIA and the @oeaw.bsky.social

Data- and knowledge-derived functional landscape of human solute carriers | Molecular Systems Biology imageimageA comprehensive knowledgebase on the 464 human solute carrier (SLC) transporters has been established. It consolidates basic annotations, systematic multi-omics data sets, and curated information from the public domain. This resource is ...

We integrated RESOLUTE data with public datasets to build a comprehensive, open-access #SoluteCarrier resource—systematically mapping their biochemical functions and biological roles. A blueprint for extracting insights from complex multi-omics data doi.org/10.1038/s443...

The genetic interaction map of the human solute carrier superfamily | Molecular Systems Biology imageimageComprehensive genetic interaction mapping of solute carrier (SLC) transporters reveals principles of cellular transport organization and metabolic adaptation. Systematic CRISPR screening with Cas12a and Cas9 systems identified 1236 ...

Over 35,000 double knockouts revealed synthetic lethal pairs and redundancies, highlighting therapeutic targets—especially in mitochondrial #SLCs. SLC39A1, a zinc #transporter, surprisingly drives metabolic rewiring and anti-apoptotic signaling in cancer. doi.org/10.1038/s443...

The solute carrier superfamily interactome | Molecular Systems Biology imageimageProtein-protein interaction (PPI) mapping of human solute carrier (SLC) transporter superfamily. Interactions affecting SLC proteostasis were validated by a high-throughput RNAi-based protein stability and localization assay to assess ...

Highlights include #PDZ-domain roles in trafficking and degrons in stability—uncovering how #SLCs are controlled post-translationally. doi.org/10.1038/s443...

In the global survey of the SLC-protein interaction landscape we determined the protein interactions of ~400 #SLCs revealing thousands of new links.

Metabolic mapping of the human solute carrier superfamily | Molecular Systems Biology imageimageThe large collection of SLC perturbation cell lines enables parallel assessment of changes in metabolites and transcripts and the first systematic survey of the metabolic consequences of SLC...

Clustering and integration of metabolomics and transcriptomics profiles of all #SLCs enabled the linkage of #SLCs to new metabolic pathways. Further experimental validation uncovered roles in osmolyte balance and glycosylation doi.org/10.1038/s443...

Hundreds of genetically modified cell lines covering the entire #SLC superfamily were generated for systematic omics studies. By measuring metabolomics, we revealed functions for 71 unknown transporters. Among them, #SLC45A4 was found to transport polyamines

The RESOLUTE megaproject was executed by 120 researchers from 13 institutions across eight countries. We are grateful to a wonderful community that formed over more than five years. Together we paved the way for accelerated therapeutic innovation for #SoluteCarriers

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

Join us for groundbreaking science at the Keystone Symposium on Solute Carrier Transporters this April 2026 in Beverly, MA, USA! 🌟 Hosted by @giuliosupertifurga.bsky.social, David Drew, and Kathleen M. Giacomini. Save the date—https://keysym.us/KSSoluteCTs26 #KSSoluteCTs26 #solutecarriertransporters

MUSIC for SCIENTIFIC CONFERENCES on BIOENGINEERING in SICILY open.spotify.com/playlist/3HN... symposia where cutting edge science pairs with nice charismatic speakers & participants, great locations, food, art, memories = emotions. Get in the mood for the #RiMEDSymposium2025 with this playlist!

but these posts are frustrating...why don't you tell us the cause?

Great fun to walk through Palermo with Donata Sandri and Nadia Consiglio to show you where the #RiMEDSymposium2025 will take place. Incredible place. Register soon rimedsymposium.eu

Research requires an allround favorable environment, where the building, instrumentation and governance infrastructure is matched by an exciting cultural space and a really welcoming culture for intenational talents #Vienna #Wien #Austria for me is that place #TopForschungWien

my first bsky post to hail PhD student Andrè Ferdigg for his first great PhD paper in which he skilfully identifies and cleverly dissects the role of membrane transporters in mediating cellular resistance to metal toxicity, congrats Andrè keep running! www.life-science-alliance.org/content/8/2/...