MitoStarsLab

France and Germany unveil Docs, a homegrown alternative to Google Docs The Trump administration has set out to drastically reshape the relationship between the US and Europe. In response, Brussels is scrambling to adapt to this new reality,...

The days of Google Docs are ending; we enter the age of Docs, made by France's Interministerial Directorate for Digital Affairs and Germany's Center for Digital Sovereignty of Public Administration.

We need more governments to collaborate on public software projects to achieve digital sovereignty.

Mitochondria Summer School

Application deadline approaching fast! If you are a PhD student or a postdoc register for this summer school in the happiest country in the world. Amazing program, amazing people, amazing place! ssl.eventilla.com/mitochondria...

Mitochondria Summer School

Join this event for PhD students and postdocs in the amazing wilderness of Northern Finland! Reg. dl Thu 10th Apr. Spa hotel Rokua with plenty of saunas and pools and other fun. 😎 Network and learn about mitochondria! @mitoworld.bsky.social @richterlab.bsky.social @ki.se @cecad.bsky.social

An open letter to graduate students and other procrastinators: it’s time to write - Nature Biotechnology Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

Lots of excellent advice in this piece. The core message - only through writing do you really think and order your thoughts into logical sense. Makes a case for not using AI for 1st draft because you bypass the thinking step
www.nature.com/articles/s41...
@naturebiotech.bsky.social
#PlantScience

The coming age of causality will be a rebellion against the correlation weirdos

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Celebrated picture after examination of John Meyrick for his . From left to right examiner, Tom Nichols, PHD supervisor Uwe Richter, PhD Jon Meyrick , mentor Rob Taylor, and examiner Ray O’Keefe

🍾Bursting with pride and joy! Watching you grow as a scientist and individual has been incredible. Congrats, Jon, on truly earning your 🎓PhD! Thanks to all the amazing support @taylorlabncl.bsky.social
@cgm-newcastle.bsky.social
@mitonewcastle.bsky.social and examiners Ray O’Keefe and Tom Nicholls!

Francis Collins: On Truth, Science, Faith and Trust Listen now (40 mins) | A very personal story—his inspiring new book THE ROAD TO WISDOM—and other closely related matters

My recent podcast with Francis. What he has done to advance biomedicine in the US and globally is immeasurable.
erictopol.substack.com/p/francis-co...

Pleased to see @cgm-newcastle.bsky.social and @taylorlabncl.bsky.social have joined us here

Mysterious increase in the motility of these #lysosomes

After adding a non-stimuli treatment the lysosomes (cyan) got crazy (see color coded tracks)
Maybe #mechanosignaling triggered by shear stress?

#Microscopy + #Cells for #FluorescenceFriday 🧪🔬
#SciSky #scicomm #CellBio

Congrats to Dr. Ana Andjelković from our and @richterlab.bsky.social lab for winning 2nd place in the Huygens Image Contest! 🎉🏆 Live STED imaging shows the cristae dynamics in a pathophysiological condition. svi.nl/imagecontest... #ScienceArt #ImageContest

Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social

Graphical abstract of the paper.

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

My first post!
#mRNA translation initiation and its regulation in eukaryotes.
#Ribosomes #cryoEM #RNABiology #Translation #Science

This gets better every day….

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1 Somatic mitochondrial DNA (mtDNA) mutations are heavily implicated as important drivers of ageing an

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice https://www.biorxiv.org/content/10.1101/2024.11.14.623694v1

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex!

www.biorxiv.org/content/10.1...

Happy to have my first post on this site be to share the news that our amazing student Alia will be presenting her work on mitochondrial fission at MitoChats Thursday (10am US central time)! Be sure to check it out!

[looking at Bluesky over the past 2 days] So this is what the Cambrian explosion must have felt like

Breaking down #Alzheimers disease into 5 subtypes by proteins in cerebrospinal fluid, with distinct genomic profiles and molecular processes nature.com/articles/s43...

Uber: we can't make money if we have to follow the law

Google: we can't make money if we're not allowed to be a monopoly

Nestle: we can't make money without using slave labor

OpenAI: we can't make money if we can't steal

media: should shoplifters be executed?

Tweet from Yann LeCun, which says “AI is not some sort of natural phenomenon that we have no control over. AI is being built by us, humans. Hence, if you’re scared of AI, what you were actually scared of are your fellow humans. You probably have doubts about the ability of institutions to do the right things with it. Why?”

I can’t even fathom how clueless a person would need to be to say this out loud.

Open any history book, any corporate lawsuit and see how far you can trust humans in the face of greed. And *especially* institutions where people are “just doing their job”.