Meghna Gupta

Join us for a great session @asbmb.bsky.social annual meeting tomorrow. Our session starts at 9:30 am!

On my way to DC and looking forward to this exciting mini-symposium! #ASBMB26

Glad to see this news story highlighting our recent lipid interactome database, a resource we hope will help the broader scientific community. @ohsummi.bsky.social @ohsunews.bsky.social

news.ohsu.edu/2026/02/25/n...

🎗️ February marked Gallbladder & Bile Duct Cancer Awareness Month, highlighting #Cholangiocarcinoma.

Often diagnosed at advanced stages, with limited early detection.

#RareCancers remain part of the broader #Oncology landscape.

🔗 https://bit.ly/3KQY0tS

#RareDiseaseDay #RareDisease

💚 February is Cholangiocarcinoma Awareness Month! 💚

All month long, we’re coming together to raise awareness, share stories from patients and caregivers, and shine a light on this cancer. This is a time to learn, connect, and amplify voices that deserve to be heard. curecca.link/awarenessmonth26.

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon

Our paper on The Lipid Interactome is now published, and the database is open:

lipidinteractome.org

@ohsummi.bsky.social @ohsunews.bsky.social
@nadlerlab.bsky.social @jeremybaskin.bsky.social

Please RT to spread the word.

doi.org/10.1093/bioi...

Most people have never heard of cholangiocarcinoma, yet it’s the 2nd most common liver cancer. Awareness isn’t just important, it’s life-changing. Knowledge leads to early detection, research, and hope. Let’s make CCA known. Join us for #WorldCCADay tomorrow, February 19. 🌍

💚 Save the Date: World Cholangiocarcinoma Day — February 19, 2026 💚

February 19 is a global moment to raise awareness of bile duct cancer and stand with patients, caregivers, and families. This Awareness Month, explore ways to get involved and inspire action: https://curecca.link/awarenessmonth26.

@asbmb.bsky.social
www.asbmb.org/meetings-eve...

Big career update: 
I’m honored and humbled to serve as Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University (OHSU). Looking forward to what we’ll build together! @ohsummi.bsky.social @ohsunews.bsky.social

We are organizing a mini-symposium on "Membrane and Organelle Dynamics" at ASBMB 2026! #ASBMB @asbmb.bsky.social
@aydinlab.bsky.social and I have put together a fantastic lineup of speakers for Day 1 morning. Come learn about some cutting-edge research in the field.

I’m so excited to share that I’ve accepted an assistant professor position at the University of Colorado Anschutz, BMG department and Barbara Davis Diabetes center! I’m so grateful to many who have helped me get here, especially mentors at Joslin, @hmsbpa.bsky.social @leadingedgeprogram.bsky.social

I am very excited to share the first Accorsi lab publication: a collection of detailed protocols to maintain an apple snail 🐌 colony and generate stable mutant lines. The video is coming soon @ JoVE! We hope this will be a valuable resource for the community. app.jove.com/t/69267/the-...

Molecular mechanism of substrate transport by human peroxisomal ABCD3 pubmed.ncbi.nlm.nih.gov/41428872/ #cryoEM

Grateful to all our co-authors and collaborators Sree Ganesh Balasubramani, Sasha Dickinson, Alexander Myasnikov, Ignacia Echeverria, Robert Stroud. Your expertise and support were invaluable to this work.

Thanks to our funding sources- National Institute on Aging (NIA) and @ahascience.bsky.social

This work represents a major milestone in understanding how peroxisomal transporters function at the molecular level. Gupta lab members- @nkhandelwal.bsky.social and , @devinseka.bsky.social made critical contributions that pushed this project forward.

Exciting holiday present for the Gupta lab! 🎉 🎊

Our paper "Molecular mechanism of substrate transport by human peroxisomal ABCD3" is now published in @pnas.org !! 🎉 🎊 lnkd.in/gPaFdEMn.
@ohsunews.bsky.social #OHSU #mguptalab #NIHfunded

www.mguptalab.com

Dinner with the group afterward was a great way to continue the conversation.

#Peroxisomes #CellBiology #ASCB2025 #CellBio2025

Nice to see the breadth of work happening in peroxisome biology at this session #CellBio2025. 🔬

Great start to #CellBio2025 in Philadelphia with "The Peroxisome Renaissance: From Molecular Mechanisms to Cellular Functions" session organized by @fredmast.bsky.social.

Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

Prohibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁‍♀️💎✨VIP section💅🪩🥂

Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics.

s/o to #teamtomo #cryoET co-authors
@hamid13r.bsky.social
@attychang.bsky.social
@baradlab.com

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....

Candid photo of Zara Weinberg. She has short red hair, bangs and glasses. She is laughing.

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.

The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.

www.leadingedgesymposium.org/apply/

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed.
She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Zara Weinberg was a brilliant light both in and out of science. She changed the lives of everyone she interacted and loved for the better. Her legacy will live on through all of us and we will fight for a better world on behalf of her memory.

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech.
We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!!
www.nature.com/articles/s41...

Explainer 1/8

Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...