Nathalie Sibille

@nsibille

PhD in Biophysics, CNRS research director, team leader at Montpellier University NMR spectroscopist, structural biologist & IDPs, phosphorylation, PTMs, GPCRs and cell signaling lover

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Posts 30.11.2024
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Latest posts by Nathalie Sibille @nsibille

Tribune : Cessez de parler « d’autocensure » | Association Femmes et sciences 📣 Tribune Cessez de parler « d’autocensure » : ce ne sont pas les femmes qui se taisent, ce sont les structures qui les réduisent au silence Parler d’autocensure pour expliquer la faible présence de...

www.linkedin.com/posts/femmes...

04.11.2025 22:25 👍 4 🔁 2 💬 0 📌 1

Lipids modulate the dynamics of GPCR: β-arrestin interaction To analyze the ability of the human β-arrestin 1 to interact with membranes, a fluorescent probe, monobromobimane (MB), was first inserted at positions 68 or 191 of a cysteine-free mutant of wild-type β-arrestin 1 (mutated cysteines are reported in the...

Lipids modulate the dynamics of GPCR: β-arrestin interaction
->Nature | More info from EcoSearch

29.05.2025 23:55 👍 0 🔁 1 💬 0 📌 0

LIPIDS MODULATE THE DYNAMICS OF GPCR:β-ARRESTIN INTERACTION https://www.biorxiv.org/content/10.1101/2024.03.16.585329v1 {beta}-arrestins are key privileged molecular partners of G-Protein Coupled Receptors (GPCRs), trigg

LIPIDS MODULATE THE DYNAMICS OF GPCR:β-ARRESTIN INTERACTION https://www.biorxiv.org/content/10.1101/2024.03.16.585329v1

17.03.2024 19:50 👍 1 🔁 1 💬 0 📌 0

I would love to be part of this, thank you in advance!

08.01.2025 11:45 👍 0 🔁 0 💬 1 📌 0

IDPfun2 on LinkedIn: #idpfun2project 🚀 Meet the Partners of IDPfun2! We are excited to introduce the key members of our international research team in the #IDPfun2project. Today, we feature…

www.linkedin.com/posts/idpfun...

17.12.2024 14:06 👍 5 🔁 0 💬 0 📌 0

x.com

x.com/IDPfun/statu...

17.12.2024 14:06 👍 0 🔁 0 💬 0 📌 0

IDPfun2 on LinkedIn: #idpfun2project 🚀 Meet the Partners of IDPfun2! We are excited to introduce the key members of our international research team in the #IDPfun2project. Today, we feature…

linkedin.com/posts/idpfun2_…

17.12.2024 14:04 👍 1 🔁 0 💬 0 📌 0

Laurent Maveyraud on LinkedIn: La 11ème édition de l'école de Biologie Structurale Intégrative, organisée… La 11ème édition de l'école de Biologie Structurale Intégrative, organisée par RéNaFoBis à Oléron touche à sa fin ! Encore une édition bien réussie ! Merci…

linkedin.com/posts/laurent-…

05.06.2024 20:03 👍 0 🔁 0 💬 0 📌 0

Coop-Egal on LinkedIn: Un réseau est né 🚀 + 1 pour l'égalité ! Coop-Egal est fière d'avoir… Un réseau est né 🚀 + 1 pour l'égalité ! Coop-Egal est fière d'avoir accompagné et animé avec Romain Sabathier la 1ère Rencontre des Référent·es Égalité dans…

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07.12.2023 16:02 👍 0 🔁 0 💬 0 📌 0

It's fantastic to see our latest results in @Structure_CP, highligted by @irenecoin and Daniel Huster, in the fascinating world of @GPCR, @IDPs, and @NMR. Congratulations to my team @CNRS @umontpellier 🥳👏, funded by @AgenceRecherche GPCteR. Thank you 🙌🔬

doi.org/10.1016/j.str.…

07.11.2023 19:03 👍 0 🔁 0 💬 0 📌 0

Very happy to share our last results in @Structure on @GPCR, @IDPs & @NMR at @CNRS and @UniversityMontpellier with the support of #ANR GPCteR. Congratulations to my team 👏 @Myriam Guillien and @AssiaMouhand, @AminSagar1 and all involved in the project.

sciencedirect.com/science/articl…

04.09.2023 15:53 👍 0 🔁 0 💬 0 📌 0

Retour sur la 10ième Ecole Nationale de Biologie Structurale Intégrative Renafobis Site de l'Association Française de Cristallographie

afc.asso.fr/l-association/…

26.06.2023 08:54 👍 0 🔁 0 💬 0 📌 0

Very happy to share our last results on the #ANR GPCteR project at #CNRS. Congrats to my team 👏 : @myriamguillien, @AssiaMouhand, @AminSagar1

x.com/biorxivpreprin…

26.02.2023 18:18 👍 0 🔁 0 💬 0 📌 0

Assia MOUHAND on LinkedIn: #idp #gpcr #arrestine #nmr #saxs Proud to be a part of this amazing work from Dr. Nathalie Sibille's group (Centre de Biologie Structurale at Montpellier) The first structural insights into…

linkedin.com/posts/assia-mo…

22.04.2022 08:29 👍 0 🔁 0 💬 0 📌 0

Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR) Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) form heterodimers that activate target gene transcription by recruiting co-activator complexes in response to ligand binding. The nuclear receptor (NR) co-activator TIF2 mediates this recruitment by interacting with the ligand-binding domain (LBD) of NRs trough the nuclear receptor interaction domain (TIF2NRID) containing three highly conserved α-helical LxxLL motifs (NR-boxes). The precise binding mode of this domain to RXR/RAR is not clear due to the disordered nature of TIF2. Here we present the structural characterization of TIF2NRID by integrating several experimental (NMR, SAXS, CD, SEC-MALS) and computational data. Collectively, the data are in agreement with a largely disordered protein with partially structured regions, including the NR-boxes and their flanking regions, which are evolutionary conserved. NMR and X-ray crystallographic data on TIF2NRID in complex with RXR/RAR reveal a cooperative binding of the three NR-boxes as well as an active role of their flanking regions in the interaction. ### Competing Interest Statement The authors have declared no competing interest.

Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR

biorxiv.org/content/10.110…

29.10.2020 09:25 👍 0 🔁 0 💬 0 📌 0

The GPCR Consortium Thinking about GPCRs as IDPs... https://www.sciencedirect.com/science/article/pii/S1877117320300685?via%3Dihub

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27.09.2020 22:18 👍 0 🔁 0 💬 0 📌 0