James Herbort

A flexible and scalable synthesis of 4′-thionucleosides 4′-Thionucleosides (thNAs) are synthetic nucleoside analogues that have attracted attention as leads for drug discovery in oncology and virology. Here we report a de novo thNA synthesis that relies on...

So excited to see this published! Thionucleosides can be incredibly challenging to make due to the need for oxidation state changes at sulfur during the synthesis. Collaborating with the Britton group, we’ve been able to make them using a short, selective sequence!
pubs.rsc.org/en/content/a...

Created a Starter Pack for Industry Chemists- let me know if you want in! #ChemSky

Yes please!